A5026139057- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Drug Transport and Resistance Mechanisms
- Natural product bioactivities and synthesis
- Plant-based Medicinal Research
- thermodynamics and calorimetric analyses
- Immune Response and Inflammation
- Respiratory viral infections research
- Traditional Chinese Medicine Analysis
- Liver Diseases and Immunity
- Hepatitis C virus research
- Inflammasome and immune disorders
- Phytochemistry and biological activity of medicinal plants
- Flavonoids in Medical Research
- Medicinal Plant Pharmacodynamics Research
- interferon and immune responses
- Berberine and alkaloids research
- Circular RNAs in diseases
- Chromatography in Natural Products
- Heart Failure Treatment and Management
- Drug-Induced Hepatotoxicity and Protection
- Viral Infections and Immunology Research
Chinese PLA General Hospital
2019-2025
Taiyuan Central Hospital
2025
Chengdu University of Traditional Chinese Medicine
2025
Guangxi University
2024
302 Military Hospital of China
2009-2023
Southern Medical University
2022-2023
Changchun Children's Hospital
2011-2020
Chinese People's Liberation Army
2009-2019
Henan Agricultural University
2019
First Affiliated Hospital of Zhengzhou University
2019
The hepatotoxicity of some Chinese herbs has been a cause for concern in recent years. However, herbs, such as rhubarb, have documented having both therapeutic and toxic effects on the liver, leading to complex problem distinguishing benefits from risks using this herb. To comparatively analyze dose-response relationship between rhubarb hepatic health, we administrated total extract (RE) normal carbon tetrachloride (CCl(4))-treated rats 12 weeks at 4 dosage levels (2.00, 5.40, 14.69 40.00...
The tripeptide reduced glutathione (GSH; γ-glutamate [Glu]-cysteine [Cys]-glycine) is a major endogenous antioxidant in both animal and plant cells. It also functions as neurotransmitter mediating communication among neurons the central nervous system of animals through modulating specific ionotropic Glu receptors (GLRs) membrane. Little known about such signaling roles Here, we report that transient rises cytosolic calcium triggered by exogenous GSH Arabidopsis (Arabidopsis thaliana) leaves...
Berberine (BBR) is widely used to treat gastrointestinal diseases. However, the pharmacological mechanism of action BBR in anti-chronic atrophic gastritis (CAG) remains unclear. This study aimed investigate CAG by integration molecular biology and multi-omics studies strategy. The model was established alternating drinking water 0.1% ammonia 20 mmol/L sodium deoxycholate, accompanied an irregular diet. Serum biochemical indices including PGI, PGII, GAS-17, IL-6, IL-1β, TNF-α were analyzed....
This article documents the addition of 238 microsatellite marker loci and 72 pairs Single Nucleotide Polymorphism (SNP) sequencing primers to Molecular Ecology Resources Database. Loci were developed for following species: Adelges tsugae, Artemisia tridentata, Astroides calycularis, Azorella selago, Botryllus schlosseri, Botrylloides violaceus, Cardiocrinum cordatum var. glehnii, Campylopterus curvipennis, Colocasia esculenta, Cynomys ludovicianus, leucurus, gunnisoni, Epinephelus coioides,...
Abstract Doxorubicin (Dox), one of the most effective chemotherapy drug for cancer treatment, is limited by its severe side effects and chemoresistance. Dox induces DNA damage leads to significant proteomic changes in cells, which makes ubiquitin-proteasome system a potential target enhance efficacy therapy. The unsuccessful clinical trials proteasome inhibitor PS-341 (bortezomib) solid tumors led invention MLN9708 (ixazomib), an orally bioavailable next-generation with improved...
Abstract Smart transportation is an important application scenario in the field of urban computing. As popularity electric vehicles increases, demand for fast charging growing rapidly. In response to this, battery swapping stations are being proposed as a solution, but their operational efficiency challenged by factors such life, vehicle queues, and grid load management. this paper, mixed intelligent optimization strategy combining proximal policy (PPO) algorithm from reinforcement learning...
Lobular capillary hemangioma (LCH), typically a benign vasoproliferative lesion of the skin or mucosal surfaces, is exceptionally rare in trachea. Now, we present second reported case LCH found right intermediate bronchus, characterized by calcification within and cystic changes. These distinctive features should alert clinicians to consider differential diagnosis other vascular tumors mediastinal lymphadenopathy, particularly when calcified lesions are observed.
Some recent clinical reports have shown that the combination of oxymatrine, a phyto-derived drug, with lamivudine (3TC) could improve its curative effect against hepatitis B virus (HBV) infection. However, experimental data in support this strategy are lacking. In study, we investigated anti-HBV activity 3TC and either oxymatrine or matrine on HepG2 2.2.15 vitro. The activities solo compound, each different concentrations, were compared 3rd, 6th, 9th days. cytotoxicity results showed...
Abstract Doxorubicin (Dox, Adriamycin) has been widely used in breast cancer treatment. But its severe cardio-toxic side effects limited the clinical use. Dox treatment can induce DNA damage and other accompanying cells, subsequently activates nuclear factor κB (NF-κB) pathway which a strong pro-survival role different types of malignancy. We hypothesize that blocking NF-κB may sensitize cells to chemotherapy. TGFβ-activated kinase-1 (TAK1) is key intracellular molecule participating...
Abstract Sevoflurane is the most widely used anesthetic administered by inhalation. Exposure to sevoflurane can elicit learning deficits and abnormal cognitive disorder. In this study, we investigated function of long noncoding RNA (lncRNA) Gm15621. Primary hippocampal neuron cells were analyze lncRNA Gm15621 in vitro. The tunel, inflammation markers, cell survival rates detected evaluate Dual‐luciferase reporter assay was identify interaction between microRNA 133a We found that located...