A5101985130- RNA Interference and Gene Delivery
- Drug Transport and Resistance Mechanisms
- Ginger and Zingiberaceae research
- Tea Polyphenols and Effects
- Prostate Cancer Treatment and Research
- Natural product bioactivities and synthesis
- Cancer, Lipids, and Metabolism
- Computational Drug Discovery Methods
- Transport and Economic Policies
- Flavonoids in Medical Research
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Urban and Freight Transport Logistics
- Mitochondrial Function and Pathology
- Pharmacovigilance and Adverse Drug Reactions
- Medicinal Plant Pharmacodynamics Research
- Pluripotent Stem Cells Research
- Venomous Animal Envenomation and Studies
- Renal and related cancers
- Traditional Chinese Medicine Analysis
- Healthcare and Venom Research
- Mesenchymal stem cell research
- Liver physiology and pathology
- CAR-T cell therapy research
- Autophagy in Disease and Therapy
Johannes Gutenberg University Mainz
2019-2025
Guangdong Pharmaceutical University
2021
Chengdu University of Traditional Chinese Medicine
2017
302 Military Hospital of China
2017
Northwest Minzu University
2016
Ningxia Hui Autonomous Region Peoples Hospital
2016
Sichuan University
2008
New York Medical College
2002-2004
Kansas State University
1999
Broader implementation of cell-based therapies has been hindered by the logistics associated with expansion clinically relevant cell numbers ex vivo. To overcome this limitation, Wilson Wolf Manufacturing developed G-Rex, a culture flask gas-permeable membrane at base that supports large media volumes without compromising gas exchange. Although platform recently gained traction scientific community due to its superior performance when compared traditional systems, limits technology have yet...
Predicting the impact of mutations on protein-ligand binding affinity is crucial in drug discovery, particularly addressing resistance and repurposing existing drugs. Current structure-based methods, including deep learning physics-based computational techniques, are constrained by their dependence known complex structures. The lack structural data for mutated proteins, coupled with potential to alter protein conformational states, poses challenges reliable predictions. To address challenge,...
ABSTRACT Penicillium sp. (IBWF 040‐09) produces a protease inhibitor that can potentially be used against the main of human African trypanosomiasis. Since target substance is formed intracellularly (under nutrient limitation), fungal pellet preferred compared to free mycelia in bioreactor cultivation. The optimization production became focus this study. effects concentrations spores, calcium chloride, and Pluronic F68 were investigated with regard growth, morphology, inhibitor. combination...
The Equiguard is a dietary supplement comprised of standardized extracts from nine herbs, respectively, Herba epimedium brevicornum Maxim (stem and leaves), Radix morindae officinalis (root), Fructus rosa laevigatae michx (fruit), Rubus chingii Hu Schisandra chinensis (Turz.) Baill Ligustrum lucidum Ait Cuscuta Lam (seed), Psoralea corylifolia L. Astragalus membranaceus (Fisch.) Bge (root). This proprietary product, formulated according to Chinese traditional medicinal concepts, aimed at...
Podocytes are terminally differentiated glomerular epithelial cells. Podocyte loss has been found in many renal diseases. Cdk5 is a cyclin-dependent protein kinase which predominantly regulated by p35. To study the role of Cdk5/p35 podocyte survival, we first applied western blotting (WB) analysis to confirm time-course expression and p35 during kidney development cultured immortalized mouse podocytes. We also demonstrated that plays an important promoting differentiation overexpression...
Cholestatic liver disease (CLD) is a range of conditions caused by the accumulation bile acids (BAs) or disruptions in flow, which can harm and ducts. To investigate its pathogenesis treatment, it essential to establish assess experimental models cholestasis, have significant clinical value. However, owing complex single modelling method merely reflect one few pathological mechanisms, each has adaptability limitations. We summarize existing including animal models, gene-knockout cell...
The popular beverage green tea possesses chemopreventive activity against various types of tumors. However, the effects its effect on hematological malignancies have not been defined. In present study, we evaluated antitumor efficacies a specific tea, sencha sensitive and multidrug-resistant leukemia panel nine multiple myelomas (MM) cell lines. We found that extracts induced cytotoxicity in leukemic cells MM to different extents, yet normal was limited. Furthermore, caused G2/M G0/G1 phase...
Lack of life-prolonging therapies has provided much the impetus for seeking complementary and alternative management/treatment options by prostate cancer (CaP) patients. Among these, use dietary supplements botanical products been showing a sustained increase in recent years, owing part to some encouraging pre-clinical clinical data shown limited number herbal products. Notably, however, majority supplement have not rigorously studied with regard their efficacy. In vitro mechanistic...
Chronic atrophic gastritis (CAG) is considered as a significant risk factor for triggering gastric cancer incidence, if not effectively treated.