A5071993355- Drug Transport and Resistance Mechanisms
- Cancer therapeutics and mechanisms
- Natural product bioactivities and synthesis
- Computational Drug Discovery Methods
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Interference and Gene Delivery
- Bioactive Compounds and Antitumor Agents
- Melanoma and MAPK Pathways
- Medicinal Plants and Bioactive Compounds
- Genomics, phytochemicals, and oxidative stress
- HIV/AIDS drug development and treatment
- Microbial Natural Products and Biosynthesis
- Phytochemistry and Bioactive Compounds
- RNA modifications and cancer
- Protein Degradation and Inhibitors
- Curcumin's Biomedical Applications
- Plant Molecular Biology Research
- vaccines and immunoinformatics approaches
- Ginger and Zingiberaceae research
- Natural Compounds in Disease Treatment
- Ethnobotanical and Medicinal Plants Studies
- Machine Learning in Bioinformatics
- Pharmacological Effects of Natural Compounds
- Synthesis and bioactivity of alkaloids
- Cancer Genomics and Diagnostics
Johannes Gutenberg University Mainz
2015-2024
Middle East Technical University
2012
Gene expression profiling was performed on the human neuroglial cell line T98G after treatment with adaptogen ADAPT-232 and its constituents - extracts of Eleutherococcus senticosus root, Schisandra chinensis berry, Rhodiola rosea root as well several individually, namely, eleutheroside E, schizandrin B, salidroside, triandrin, tyrosol. A common feature for all tested adaptogens their effect G-protein-coupled receptor signaling pathways, i.e., cAMP, phospholipase C (PLC),...
Curcuma longa has long been used in China and India as anti-inflammatory agent to treat a wide variety of conditions also spice for varied curry preparations. The chemoprofile the species exhibits presence phytochemicals with curcumin being present all three but AA only shown C. longa. This study explored effect curcumin/AA combination on human cancer cell lines. was assessed by isobologram analysis using Loewe additivity drug interaction model. showed additive cytotoxicity toward CCRF-CEM...
ATP-binding cassette (ABC) transporters mediate multidrug resistance in cancer. In contrast to DNA single nucleotide polymorphisms normal tissues, the role of mutations tumors is unknown. Furthermore, significance their expression for prediction chemoresistance and survival prognosis still under debate. We investigated 18 by RNA-sequencing. The mutation rate varied from 27,507 300885. ABCB1, three hotspots with novel were transmembrane domains 3, 8, 9. also mined cBioPortal database 11,814...
The improvement of cancer chemotherapy remains a major challenge, and thus new drugs are urgently required to develop treatment regimes. Curcumin, polyphenolic antioxidant derived from the rhizome turmeric (Curcuma longa L.), has undergone extensive preclinical investigations and, thereby, displayed remarkable efficacy in vitro vivo against other disorders. However, pharmacological limitations curcumin stimulated synthesis numerous novel analogs, which need be evaluated for their therapeutic...
Drug resistance in cancer has been classified as innate or acquired resistance, which were characterized by apoptotic defects and ABC transporters overexpression respectively. Therefore, to preclude reverse these mechanisms could be a promising strategy improve chemotherapeutic outcomes. In this study, natural product from Osage Orange, pomiferin, was identified novel autophagy activator that circumvents triggering autophagic cell death via SERCA inhibition activation of the CaMKKβ-AMPK-mTOR...
Drug resistance and the severe side effects of chemotherapy necessitate development novel anticancer drugs. Natural products are a valuable source for drug development. Scopoletin is coumarin compound, which can be found in several Artemisia species other plant genera. Microarray-based RNA expression profiling NCI cell line panel showed that cellular response scopoletin did not correlate to ATP-binding cassette (ABC) transporters as classical mechanisms (ABCB1, ABCB5, ABCC1, ABCG2). This was...
Neferine, a bisbenzylisoquinoline alkaloid isolated from the green seed embryos of Lotus (Nelumbo nucifera Gaertn), has been previously shown to have various anti-cancer effects. In present study, we evaluated effect neferine in terms P-glycoprotein (P-gp) inhibition via vitro cytotoxicity assays, R123 uptake assays drug-resistant cancer cells, silico molecular docking analysis on human P-gp and absorption, distribution, metabolism excretion (ADME), quantitative structure activity...
We systematically characterised multifactorial multidrug resistance (MDR) in CEM/ADR5000 cells, a doxorubicin-resistant sub-line derived from drug-sensitive, parental CCRF-CEM cells developed vitro. RNA sequencing and network analyses (Ingenuity Pathway Analysis) were performed. Chromosomal aberrations identified by array-comparative genomic hybridisation (aCGH) multicolour fluorescence situ (mFISH). Fifteen ATP-binding cassette transporters numerous new genes overexpressed cells. The basic...