A5062826138- Glycosylation and Glycoproteins Research
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Toxin Mechanisms and Immunotoxins
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
- Radiopharmaceutical Chemistry and Applications
- Galectins and Cancer Biology
- Cancer, Hypoxia, and Metabolism
- Proteoglycans and glycosaminoglycans research
- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Angiogenesis and VEGF in Cancer
- Biomedical and Chemical Research
- Immune Cell Function and Interaction
- Transgenic Plants and Applications
- Carbohydrate Chemistry and Synthesis
- Caveolin-1 and cellular processes
- Medical and Biological Sciences
- Musculoskeletal Disorders and Rehabilitation
- Medical and Health Sciences Research
- Neuroblastoma Research and Treatments
- Anatomy and Medical Technology
University Cancer Center Hamburg
2016-2025
University Medical Center Hamburg-Eppendorf
2016-2025
Universität Hamburg
2016-2025
MSB Medical School Berlin
2022-2024
Morpho (United States)
1993-2023
University of Florence
2019
Hamburg University of Technology
2019
Hannover Re (Germany)
2016
Technical University of Munich
2016
Medizinische Hochschule Hannover
2016
The history of phenothiazines, from methylene blue via chlorpromazine to recently synthesized isomeric derivatives various neuroleptics, is reviewed in the light their antimicrobial activity and Paul Ehrlich's receptor concept. latter clearly line with most modern theories concerning drug action stereo-isomeric compounds.
Circulating tumor cells (CTC) in blood are promising new biomarkers potentially useful for prognostic prediction and monitoring of therapies patients with solid tumors including colon cancer. Moreover, CTC research opens a avenue understanding the biology metastasis However, an in-depth investigation CTCs is hampered by very low number these cells, especially colorectal Thus, establishment cell cultures permanent lines from has become most challenging task over past year. Here, we describe,...
About 50% of prostate cancers have TMPRSS2-ERG fusions with concurrent ERG overexpression. The aim this study was to determine whether clinical differences exist between ERG-positive and ERG-negative in surgically treated patients not exposed antihormonal therapy. A secondary search for these tumor classes.A tissue microarray containing samples from more than 2,800 data analyzed alterations by immunohistochemistry FISH. Results were compared phenotype, biochemical recurrence, molecular...
The overexpression of the chemokine receptor CXCR4 plays an important role in oncology, since together with its endogenous ligand, stromal cell–derived factor (SDF1-α), is involved tumor development, growth, and organ-specific metastasis. As part our ongoing efforts to develop highly specific CXCR4-targeted imaging probes aim assess suitability this ligand for first proof-of-concept studies humans, we further evaluated new <sup>68</sup>Ga-labeled high-affinity cyclic <sup>68</sup>Ga-CPCR4-2...
PURPOSE: The cell adhesion molecule CEACAM1 is involved in intercellular and subsequent signal transduction events a number of epithelia. downregulation has been demonstrated colorectal prostate carcinomas. This study sought to analyze whether its expression malignant melanoma associated with metastasis. PATIENTS AND METHODS: was immunohistochemically evaluated 100 primary cutaneous melanomas correlated metastasis 10-year follow-up. Furthermore, analyzed metastatic lesions (11 distant...
CXCR4 Imaging: Based on a high-affinity ligand, an imaging agent for CXCR4-positive tumors was developed through structure–activity relationship studies. The best compound evaluated in vivo and shown to have excellent properties as positron emission tomography (PET) tracer.
6q12-22 is the second most commonly deleted genomic region in prostate cancer. Mapping studies have described a minimally area at 6q15, containing MAP3K7/TAK1, which was recently shown to tumor suppressive properties. To determine prevalence and clinical significance of MAP3K7 alterations cancer, tissue microarray 4699 cancer samples analyzed by fluorescence situ hybridization. Heterozygous deletions were found 18.48% 2289 interpretable cancers. significantly associated with advanced stage...
Using a retrovirus-mediated cDNA expression cloning approach, we identified the grainyhead-like 2 (GRHL2) transcription factor as novel protooncogene. Overexpression of GRHL2 in NIH3T3 cells induced striking morphological changes, an increase cell proliferation, anchorage-independent growth, and tumor growth vivo. By combining microarray analysis phylogenetic footprinting with various biochemical assays, epidermal receptor family member Erbb3 target gene. In breast cancer lines,...
Uniparental parthenotes are considered an unwanted byproduct of in vitro fertilization. In utero parthenote development is severely compromised by defective organogenesis and particular cardiogenesis. Although developmentally compromised, apparently pluripotent stem cells can be derived from parthenogenetic blastocysts. Here we hypothesized that nonembryonic (PSCs) directed toward the cardiac lineage applied to tissue-engineered heart repair. We first confirmed similar fundamental properties...
Abstract Background Due to the frequent dysregulation of PI3K/AKT/mTOR signaling pathway, mTOR represents a suitable therapeutic target in hepatocellular carcinoma (HCC). However, emerging data from clinical trials HCC patients indicate that inhibition by RAD001 (Everolimus) alone has only moderate antitumor efficacy which may be due feedback activation AKT after inhibition. In this study, we analyzed effects dual and on proliferation cell lines. addition, measured each isoforms lines their...
Abstract The parasympathetic nervous system plays an important role in the pathophysiology of atrial fibrillation. Catheter ablation, a minimally invasive procedure deactivating abnormal firing cardiac tissue, is increasingly becoming therapy choice for This inevitably associated with obliteration cholinergic neurons. However, impact on ventricular electrophysiology unclear. Here we show that neurons modulate electrophysiology. Mechanical disruption or pharmacological blockade innervation...
The skeleton is a dynamic tissue continuously adapting to mechanical stimuli. Although matrix-embedded osteocytes are considered as the key mechanoresponsive bone cells, all other skeletal cell types principally exposed macroenvironmental and microenvironmental influences that could potentially affect their activities. It was recently reported Piezo1, one of two mechanically activated ion channels Piezo family, functions mechanosensor in osteoblasts osteocytes. Here we show Piezo1...
Abstract Background Epidermal growth factor receptor (EGFR) is both a driver oncogene and therapeutic target in advanced head neck squamous cell carcinoma (HNSCC). However, response to EGFR treatment inconsistent lacks markers for prediction. This study investigated EGFR-induced epithelial-to-mesenchymal transition (EMT) as central parameter tumor progression identified novel prognostic targets, candidate predictive marker therapy response. Methods Transcriptomic profiles were analyzed by...
During metastasis, cancer cells invade, intravasate, enter the circulation, extravasate, and colonize target organs. Here, we examined role of interleukin (IL)-22 in metastasis. Immune cell-derived IL-22 acts on epithelial tissues, promoting regeneration healing upon tissue damage, but it is also associated with malignancy. Il22-deficient mice treated an antibody were protected from colon-cancer-derived liver lung metastasis formation, while overexpression promoted Mechanistically, acted...
The effects of diet on the histochemical composition intestinal mucosubstances and morphology villi crypts were investigated by comparing data germ free conventionally maintained rats fed either a purified or commercial diet. influence microflora was evaluated those harbouring conventional rat flora human microbial flora. In both conventionally, feeding resulted in shallower small intestine but deeper large compared with their counterparts preliminary obtained association showed reduction...