A5046890585- RNA modifications and cancer
- Head and Neck Cancer Studies
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Lung Cancer Treatments and Mutations
- Hemoglobinopathies and Related Disorders
- Cancer Genomics and Diagnostics
- Drug Transport and Resistance Mechanisms
- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Neonatal Respiratory Health Research
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- S100 Proteins and Annexins
- Metastasis and carcinoma case studies
- Malaria Research and Control
- Sports injuries and prevention
- Cancer Immunotherapy and Biomarkers
Ludwig-Maximilians-Universität München
2020-2025
LMU Klinikum
2020-2025
Xiangya Hospital Central South University
2020-2025
Central South University
2020-2025
Soil and Fertilizer Institute of Hunan Province
2020-2025
Michigan State University
2022-2023
Abstract Background Epidermal growth factor receptor (EGFR) is both a driver oncogene and therapeutic target in advanced head neck squamous cell carcinoma (HNSCC). However, response to EGFR treatment inconsistent lacks markers for prediction. This study investigated EGFR-induced epithelial-to-mesenchymal transition (EMT) as central parameter tumor progression identified novel prognostic targets, candidate predictive marker therapy response. Methods Transcriptomic profiles were analyzed by...
The purposes of the present study are to investigate effects reduced muscle loading by prolonged immobilization on regeneration fibrocartilaginous enthesis through endochondral ossification in rabbits. Forty-eight rabbits underwent standard partial patellectomy were randomly divided into control group and (PIM) group. immobilized cast was only maintained for first 4 weeks group, while 12 or until euthanization PIM Patella-patella tendon complexes harvested Micro-CT histology at week 6, 18....
Abstract Background Recurrent/metastatic head and neck squamous cell carcinoma (R/M-HNSCC) is a severe, frequently lethal condition. Oncogene addiction to epidermal growth factor receptor (EGFR) hallmark of HNSCC, but the clinical efficacy EGFR-targeted therapies remains low. Understanding molecular networks governing EGFR-driven progression paramount exploration (co)-treatment targets predictive markers. Methods We performed function-based mapping differentially expressed genes in...
Head and neck squamous cell carcinomas (HNSCC) are characterized by strong cellular molecular heterogeneity treatment resistance entailing poor survival. Besides cell-intrinsic properties, carcinoma cells receive important cues from non-malignant within the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) a major component of TME that impact on make-up malignant have decisive function in progression. However, potential functionality tumor-adjacent, macroscopically normal...
Partial epithelial‐to‐mesenchymal transition (pEMT) contributes to cellular heterogeneity that is associated with nodal metastases and unfavorable clinical parameters in head neck squamous cell carcinomas (HNSCCs). We developed a single‐cell RNA sequencing signature‐based pEMT quantification through type‐dependent deconvolution of bulk microarray data combined single‐sample scoring molecular phenotypes (Singscoring). Clinical pEMT‐Singscores served as classifiers multivariable Cox...
Human adipose-derived stem/stromal cells (ASCs) are increasingly used as auto-transplants in regenerative medicine to restore tissue defects or induce wound healing, especially cancer patients. The impact of ASCs on squamous cell carcinoma the upper aerodigestive tract (UAT) including head and neck esophageal (HNSCC ESCC) is not yet fully understood. were cultured from subcutaneous, abdominal lipoaspirates five patients, who received neck. Supernatants tested for paracrine effects functional...
Many orthopedic surgical procedures involve reattachment between tendon and bone. Whether bone–tendon healing is better facilitated by fixation on a bone surface or within tunnel unknown. The purpose of this study was to comparatively evaluate the effects versus trough in rabbit patella–patellar (PPT) injury model. rabbits underwent partial patellectomy with patellar-tendon osteotomy (bone fixation, BSF group) (n = 28) BTF 28). PPT interface evaluated macroscopic observation, micro-computed...
Abstract Burkitt lymphoma (BL) is an aggressive B‐cell that significantly contributes to childhood cancer burden in sub‐Saharan Africa. Plasmodium falciparum , which causes malaria, geographically associated with BL, but the evidence remains insufficient for causal inference. Inference could be strengthened by demonstrating mendelian genes known protect against malaria—such as sickle cell trait variant, HBB ‐rs334(T)—also BL. We investigated this hypothesis among 800 BL cases and 3845...
ABSTRACT Therapy resistance leading to local recurrence and metastases remains highly problematic in head neck squamous cell carcinomas (HNSCC). Single RNA-sequencing defined a partial epithelial-to-mesenchymal transition (p-EMT) signature associated with HNSCC. However, the prognostic value of p-EMT potential drivers HNSCC remain unclear. Here, single sample scoring molecular phenotypes (Singscoring) served establish clinical p-EMT-Singscores that were significantly nodal predicted overall...
Introduction Human adipose-derived stem/stromal cells (ASCs) are increasingly used as auto-transplants in regenerative medicine to restore tissue defects or induce wound healing, especially cancer patients. The impact of ASCs on squamous cell carcinoma the upper aerodigestive tract (UAT) including head and neck esophageal (HNSCC ESCC) is not yet fully understood.
Einleitung Mesenchymale Stammzellen aus Fettgewebe (ASC) werden seit mehreren Jahren erfolgreich in der regenerativen Medizin und zunehmend auch im Kopf-Hals-Bereich eingesetzt, insbesondere bei Patienten nach Karzinomerkrankungen oberen Aero-Digestivtrakts. Der Einfluss von ASC auf Plattenepithel-Karzinomzellen des Aero-Digestivtrakts ist bislang weitgehend unbekannt.