A5038323479- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Prostate Cancer Treatment and Research
- Lung Cancer Treatments and Mutations
- Prostate Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Cancer-related molecular mechanisms research
- Cell death mechanisms and regulation
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Cancer Genomics and Diagnostics
- Advanced X-ray and CT Imaging
- Breast Cancer Treatment Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Meningioma and schwannoma management
- Effects of Radiation Exposure
- Gastric Cancer Management and Outcomes
- Chromatin Remodeling and Cancer
Ludwig-Maximilians-Universität München
2016-2025
German Cancer Research Center
2016-2025
Helmholtz Zentrum München
2015-2025
LMU Klinikum
2016-2025
German Center for Lung Research
2016-2025
Deutschen Konsortium für Translationale Krebsforschung
2016-2025
Heidelberg University
2016-2025
University Hospital Heidelberg
2016-2025
Huawei German Research Center
2025
München Klinik
2010-2024
Purpose Concurrent chemoradiotherapy with or without surgery are options for stage IIIA(N2) non–small-cell lung cancer. Our previous phase II study had shown the efficacy of induction chemotherapy followed by and in patients disease selected IIIB disease. Here, we compared definitive resectable III after induction. Patients Methods pathologically proven that medical/functional operability received chemotherapy, which consisted three cycles cisplatin 50 mg/m 2 on days 1 8 paclitaxel 175 day...
Patients with soft tissue sarcoma are at risk for local recurrence and distant metastases despite optimal treatment. Preoperative anthracycline plus ifosfamide chemotherapy improves outcome in common histological subtypes.To analyze whether the previously reported improvement progression-free survival by adding regional hyperthermia to neoadjuvant translates into improved survival.Open-label, phase 3 randomized clinical trial evaluate efficacy toxic effects of hyperthermia. Adult patients...
The COVID-19 pandemic has caused radiotherapy resource pressures and led to increased risks for lung cancer patients healthcare staff. An international group of experts in established this practice recommendation pertaining whether how adapt the pandemic.For ESTRO & ASTRO endorsed project, 32 contributed a modified Delphi consensus process. We assessed potential adaptations two scenarios. first, an early scenario risk mitigation, is characterized by altered risk-benefit ratio due their...
We examined the prognostic value of tumour-infiltrating lymphocytes (TILs) in patients with squamous cell carcinoma head and neck (SCCHN) after surgery postoperative cisplatin-based chemoradiotherapy. FFPE-tissue originating from 161 treated 8 DKTK partner sites was immunohistochemically stained for CD3 CD8. Their expression correlated clinicopathological characteristics as well overall survival (OS), local progression-free (LPFS) distant metastases free-survival (DMFS), also context...
Radiomics applies machine learning algorithms to quantitative imaging data characterise the tumour phenotype and predict clinical outcome. For development of radiomics risk models, a variety different is available it not clear which one gives optimal results. Therefore, we assessed performance 11 combined with 12 feature selection methods by concordance index (C-Index), loco-regional control (LRC) overall survival for patients head neck squamous cell carcinoma. The considered are able deal...
In patients with newly diagnosed glioblastoma that harbors a nonmethylated O(6)-methylguanine-DNA methyltransferase promotor, standard temozolomide (TMZ) has, at best, limited efficacy. The GLARIUS trial thus explored bevacizumab plus irinotecan (BEV+IRI) as an alternative to TMZ.In this phase II, unblinded 182 in 22 centers were randomly assigned 2:1 BEV (10 mg/kg every 2 weeks) during radiotherapy (RT) followed by maintenance IRI(125 mg/m(2) or daily TMZ (75 mg/m(2)) RT six courses of...
The induction of tumor cell death is one the major goals radiotherapy and has been considered to be central determinant its therapeutic outcome for a long time. However, accumulating evidence suggests that success does not only derive from direct cytotoxic effects on cells alone, but instead might also depend - at least in part innate as well adaptive immune responses, which can particularly target survive local irradiation. clearance dying by phagocytic system represents crucial step this...
The observation that human meningioma cells strongly express somatostatin receptor (SSTR 2) was the rationale to analyze retrospectively in how far DOTATOC PET/CT is helpful improve target volume delineation for intensity modulated radiotherapy (IMRT).In 26 consecutive patients with preferentially skull base meningioma, diagnostic magnetic resonance imaging (MRI) and planning-computed tomography (CT) complemented data from [(68)Ga]-DOTA-D Phe(1)-Tyr(3)-Octreotide (DOTATOC)-PET/CT. Image...