A5029061246- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Advanced MRI Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- MRI in cancer diagnosis
- Lung Cancer Treatments and Mutations
- Advanced X-ray and CT Imaging
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Medical Imaging and Pathology Studies
- Nuclear Physics and Applications
- NF-κB Signaling Pathways
- Superconducting Materials and Applications
- Cardiac tumors and thrombi
- Atomic and Subatomic Physics Research
- Colorectal Cancer Surgical Treatments
- Lung Cancer Research Studies
- Chemokine receptors and signaling
- DNA Repair Mechanisms
- Advanced Sensor Technologies Research
University of Tübingen
2014-2024
German Cancer Research Center
2014-2021
Heidelberg University
2014-2021
Deutschen Konsortium für Translationale Krebsforschung
2014-2021
Medical Cañada (Spain)
2020
University Hospital Carl Gustav Carus
2018
University Hospital Heidelberg
2018
TU Dresden
2018
RaySearch Laboratories (Sweden)
2017
NKT Holding (Denmark)
2016
We examined the prognostic value of tumour-infiltrating lymphocytes (TILs) in patients with squamous cell carcinoma head and neck (SCCHN) after surgery postoperative cisplatin-based chemoradiotherapy. FFPE-tissue originating from 161 treated 8 DKTK partner sites was immunohistochemically stained for CD3 CD8. Their expression correlated clinicopathological characteristics as well overall survival (OS), local progression-free (LPFS) distant metastases free-survival (DMFS), also context...
Radiomics applies machine learning algorithms to quantitative imaging data characterise the tumour phenotype and predict clinical outcome. For development of radiomics risk models, a variety different is available it not clear which one gives optimal results. Therefore, we assessed performance 11 combined with 12 feature selection methods by concordance index (C-Index), loco-regional control (LRC) overall survival for patients head neck squamous cell carcinoma. The considered are able deal...
Combined positron emission tomography (PET)/magnetic resonance imaging (MRI) is highly promising for biologically individualized radiotherapy (RT). Hence, the purpose of this work was to develop an accurate and robust registration strategy integrate combined PET/MR data into RT treatment planning. Material methods. Eight patient datasets consisting FDG PET/computed (CT) a subsequently acquired head neck (HN) region were available. Registration strategies developed based on CT MR only,...
Background. To investigate the effect of hypoxia tracer properties on positron emission tomography (PET) image quality for three tracers [18F]-fluoromisonidazole (FMISO), [18F]-fluoroazomycinarabinoside (FAZA) and [18F]-flortanidazole (HX4), using mathematical simulations based microscopic tumor tissue sections.Material methods. Oxygen distribution binding was mathematically simulated immunohistochemically stained cross-sections xenografts. Tracer diffusion were determined available...
Based on the development of new hybrid machines consisting an MRI and a linear accelerator, magnetic resonance image guided radiotherapy (MRgRT) has revolutionized field adaptive treatment in recent years. Although increasing number studies have been published, investigating technical clinical aspects this technique for various indications, utilizations MRgRT head neck cancer (HNC) remains its infancy. Yet, possible benefits novel technology HNC patients, allowing better soft-tissue...
Tumor cells frequently overexpress heat shock protein 70 (Hsp70) and present it on their cell surface, where can be recognized by pre‐activated NK cells. In our retrospective study the expression of Hsp70 was determined in relation to tumor‐infiltrating CD56 + formalin‐fixed paraffin embedded (FFPE) tumor specimens patients with SCCHN ( N = 145) as potential indicators for survival disease recurrence. All received radical surgery postoperative cisplatin‐based radiochemotherapy (RCT)....
Abstract Purpose: The aim of this study was to identify and independently validate a novel gene signature predicting locoregional tumor control (LRC) for treatment individualization patients with locally advanced HPV-negative head neck squamous cell carcinomas (HNSCC) who are treated postoperative radio(chemo)therapy (PORT-C). Experimental Design: Gene expression analyses were performed using NanoString technology on multicenter training cohort 130 an independent validation 121 patients....
Our purpose was to evaluate an imaging parameter–response relationship between the extent of tumor hypoxia quantified by dynamic <sup>18</sup>F-fluoromisonidazole (<sup>18</sup>F-FMISO) PET/CT and risk relapse after radiotherapy in patients with head neck cancer. <b>Methods:</b> Before a prospective cohort 25 cancer started radiotherapy, they were examined <sup>18</sup>F-FMISO 0–240 min tracer injection. image parameters, including metric, <i>M</i><sub><i>FMISO</i></sub><i>,</i> derived from...
Background and purposeOnline adaptive magnetic resonance imaging (MRI)-guided radiotherapy requires fast dose calculation algorithms to reduce intra-fraction motion uncertainties improve workflow efficiency. While Monte-Carlo simulations are precise but computationally intensive, neural networks promise accurate modelling in strong fields. This study aimed train evaluate a deep network for MRI-guided using comprehensive clinical dataset.Materials methodsA dataset of 6595 irradiation segments...
Hypoxia can be assessed non-invasively by positron emission tomography (PET) using radiotracers such as [(18)F]fluoromisonidazole (Fmiso) accumulating in poorly oxygenated cells. Typical features of dynamic Fmiso PET data are high signal variability the first hour after tracer administration and slow formation a consistent contrast. The purpose this study is to investigate whether these characteristics explained current conception underlying microscopic processes identify fundamental...
Background. To determine by treatment plan comparison differences in toxicity risk reduction for patients with head and neck squamous cell carcinoma (HNSCC) from proton therapy either used complete or sequential boost only.Materials methods. For 45 HNSCC patients, intensity-modulated photon (IMXT) (IMPT) plans were created including a dose escalation via simultaneous integrated one-step adaptation strategy after 25 fractions treatment. Dose accumulation was performed pure IMXT treatment,...
Stereotactic body radiotherapy (SBRT) is an established ablative treatment for liver tumors with excellent local control rates. Magnetic resonance imaging guided (MRgRT) provides superior soft tissue contrast and may therefore facilitate a marker-less SBRT workflow. The goal of the present study was to investigate feasibility, workflow parameters, toxicity patient acceptance MRgSBRT on 1.5 T MR-Linac.
Functional PET/MRI has great potential to improve radiotherapy planning (RTP). However, data integration requires imaging with radiotherapy-specific patient positioning. Here, we investigated the feasibility and image quality of radiotherapy-customized in head-and-neck cancer (HNC) patients using a dedicated hardware setup.Ten HNC were examined simultaneous before treatment, diagnostic scan setup, respectively. We tested positioning compared between both setups by pairwise analysis...
Purpose The aim of this pilot study was to explore simultaneous functional PET/MR for biological characterization tumors and potential future treatment adaptations.To investigate the extent complementarity between different PET/MR-based datasets, a pairwise correlation analysis performed.Methods Functional datasets N=15 head neck (HN) cancer patients were evaluated.For group A (N=7), combined including FDG-PET ADC maps available.Patients B (N=8) had FMISO-PET, DCE-MRI from PET/MRI, an...
To develop, implement, and validate a full 1.5 T/7 MV magnetic resonance (MR)-Linac accelerator head cryostat model in EGSnrc for high precision dose calculations accounting field effects that are independent from the vendor treatment planning system.Primary electron beam parameters implemented were adapted to be accordance with measured profiles of Elekta Unity (Elekta AB, Stockholm, Sweden). Parameters investigated mean energy as well Gaussian radial intensity distributions. Energy tuning...