A5040200486- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Meningioma and schwannoma management
- Neurosurgical Procedures and Complications
- Spine and Intervertebral Disc Pathology
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Acute Ischemic Stroke Management
- Immune cells in cancer
- Brain Metastases and Treatment
- Macrophage Migration Inhibitory Factor
- Spinal Hematomas and Complications
- Cerebrovascular and Carotid Artery Diseases
- Transcranial Magnetic Stimulation Studies
- Fetal and Pediatric Neurological Disorders
- Head and Neck Surgical Oncology
- S100 Proteins and Annexins
- Cervical and Thoracic Myelopathy
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Intraoperative Neuromonitoring and Anesthetic Effects
- Spinal Dysraphism and Malformations
University of Göttingen
2016-2025
Universitätsmedizin Göttingen
2016-2025
Neurological Surgery
2024
University Medical Center
2014-2022
Helios Klinikum Erfurt
2022
RWTH Aachen University
2003-2017
Unfallkrankenhaus Berlin
2010-2017
Medizinische Hochschule Hannover
2010-2017
Dietrich Bonhoeffer Klinikum
2017
University of Freiburg
2016
OBJECTIVE The influence of the degree resection on survival in patients with glioblastoma multiforme is still under discussion. highly controlled 5-aminolevulinic acid study provided a unique platform for addressing this question as result high frequency "complete" resections, revealed by postoperative magnetic resonance imaging scans achieved fluorescence-guided and homogeneous patient characteristics. METHODS Two hundred forty-three per protocol from were analyzed. Patients complete...
Robotic-guided and percutaneous pedicle screw placement are emerging technologies. We here report a retrospective cohort analysis comparing conventional open to robotic-guided placement. 112 patient records CT scans were analyzed concerning the intraoperative perioperative course. 35 patients underwent percutaneous, 20 57 94.5% of robot-assisted 91.4% conventionally placed screws found be accurate. Percutaneous robotic subgroups did not differ obviously. Average X-ray exposure per was 34 s...
OBJECTIVE The quest to improve the safety and accuracy decrease invasiveness of pedicle screw placement in spine surgery has led a markedly increased interest robotic technology. SpineAssist from Mazor is one most widely distributed systems. aim this study was compare robot-guided conventional freehand fluoroscopy-guided thoracolumbar surgery. METHODS This retrospective series 169 patients (83 women [49%]) who underwent instrumentation 2007 2015 2 reference centers. Pathological entities...
In patients with newly diagnosed glioblastoma that harbors a nonmethylated O(6)-methylguanine-DNA methyltransferase promotor, standard temozolomide (TMZ) has, at best, limited efficacy. The GLARIUS trial thus explored bevacizumab plus irinotecan (BEV+IRI) as an alternative to TMZ.In this phase II, unblinded 182 in 22 centers were randomly assigned 2:1 BEV (10 mg/kg every 2 weeks) during radiotherapy (RT) followed by maintenance IRI(125 mg/m(2) or daily TMZ (75 mg/m(2)) RT six courses of...
After aneurysmal subarachnoid hemorrhage, the use of lumbar drains has been suggested to decrease incidence delayed cerebral ischemia and improve long-term outcome.To determine effectiveness early cerebrospinal fluid drainage added standard care in patients after hemorrhage.The EARLYDRAIN trial was a pragmatic, multicenter, parallel-group, open-label randomized clinical with blinded end point evaluation conducted at 19 centers Germany, Switzerland, Canada. The first patient entered January...
Glioblastoma multiforme (GBM) is the most frequent and devastating primary brain tumor in adults. The presence of epigenetic lesions, like hypermethylation known suppressor genes such as MGMT, has been widely described GBM, but to our knowledge, a genome-wide profile DNA methylation changes these lethal tumors not yet available. In present analysis, we have quantified level 1,505 CpG dinucleotides (807 genes) 87 consecutive GBMs using universal BeadArrays. Supervised cluster analyses...
<h3>BACKGROUND AND PURPOSE:</h3> Autoimmune hypophysitis (AH) mimics the more common nonsecreting pituitary adenomas and can be diagnosed with certainty only histologically. Approximately 40% of patients AH are still misdiagnosed as having macroadenoma undergo unnecessary surgery. MR imaging is currently best noninvasive diagnostic tool to differentiate from adenomas, though no single radiologic sign diagnostically accurate. The purpose this study was develop a scoring system that summarizes...
Glioblastoma is the most common malignant brain tumor in adults. The currently available treatments offer only a palliative survival advantage and need for effective remains an urgent priority. Activation of p53 growth suppression/apoptotic pathway one promising strategies targeting glioma cells. We show that quinoline derivative chloroquine activates suppresses cells vitro vivo orthotopic (U87MG) human glioblastoma mouse model. Induction apoptosis mechanisms underlying effects on...
OBJECTIVE Robot-guided pedicle screw placement is an established technique for the of screws. However, most studies have focused on degenerative disease. In this paper, authors focus metastatic spinal disease, which associated with osteolysis. The lack dense bone may potentially affect automatic recognition accuracy radiography-based surgical assistance systems. aim present study to compare SpineAssist robot system conventional fluoroscopy-guided thoracolumbar METHODS Seventy patients...
Randomized phase III trials have shown significant improvement of survival 1, 2, and 3 years after implantation 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) wafers for patients with newly diagnosed malignant glioma. But these studies subsequent non-phase also risks associated local chemotherapy within the central nervous system. The introduction concomitant radiochemotherapy temozolomide (TMZ) has later demonstrated a benefit in trial become current treatment standard glioma patients....
Treatment options for oncological diseases have been enhanced by the advent of targeted therapies. The point mutation BRAF gene at codon 600 (BRAF V600E) is found in several tumor entities and can be approached with selective inhibitory antibodies. inhibitor vemurafenib has demonstrated clinical efficacy patients V600E-mutant melanoma brain metastases other cancer diseases. Therefore V600E a highly interesting target tumors.This study assesses status 969 intracranial neoplasms using tissue...
Background and Purpose: The purpose of this study was to assess nationwide incidence outcomes aneurysmal subarachnoid hemorrhage (aSAH). Swiss SOS (Swiss Study on Subarachnoid Hemorrhage) established in 2008 offers the unique opportunity provide data from point care a level. Methods: All patients with confirmed admitted between January 1, 2009 December 31, 2014, within Switzerland were recorded prospective registry. Incidence rates calculated based time-matched population data. Admission...
PURPOSE Prospective data suggested a superiority of intraoperative MRI (iMRI) over 5-aminolevulinic acid (5-ALA) for achieving complete resections contrast enhancement in glioblastoma surgery. We investigated this hypothesis prospective clinical trial and correlated residual disease volumes with outcome newly diagnosed glioblastoma. METHODS This is controlled multicenter parallel-group two center-specific treatment arms (5-ALA iMRI) blinded evaluation. The primary end point was resection on...
OBJECTIVE Laminectomy and bilateral laminotomy are the standard procedures for decompression of lumbar spinal stenosis (LSS). With aim less invasiveness better preservation stability, technique unilateral (ULBD) was developed. However, limited follow-up data exist to determine efficiency outcome ULBD. Therefore, authors present their 10-year experience with ULBD postoperative long-term results. METHODS One hundred thirty-three consecutive patients (73 men 60 women; mean age, 63 yr) meeting...
After aneurysmal subarachnoid hemorrhage (SAH), patients frequently present with persistent bodily, psychosocial, and cognitive impairments that resemble those of untreated partial or complete pituitary insufficiency. Because these similarities, the authors hypothesized SAH may cause dysfunction. Pituitary function testing was performed in 40 between 12 72 months after SAH. A combined TRH-LHRH-arginine test insulin tolerance were on two separate days. Only 18 (45%) tested had normal...
OBJECTIVE Minimal access surgery as a less invasive alternative to standard macro- and microsurgical approaches is becoming increasingly popular in the management of traumatic degenerative spine diseases. However, data lacking if minimal indeed beneficial. This prospective randomized study was conducted compare efficiency, safety, outcome open discectomy (SOMD) for lumbar disc herniation with using an 11.5 mm trocar system spine. METHODS Sixty patients were two groups 30 each. Group 1...
// Laila Siam 1 , Annalen Bleckmann 2, 3 Han-Ning Chaung 2 Alexander Mohr 4 Florian Klemm Alonso Barrantes-Freer 5 Raquel Blazquez Hendrik A. Wolff 6 Lüke 7 Veit Rohde Christine Stadelmann Tobias Pukrop Department of Neurosurgery, University Medical Center, Göttingen, Germany Hematology and Oncology, Statistics, Neuroradiology, Institute Neuropathology, Radiotherapy Radiation Internal Medicine III, Hospital Regensburg, Correspondence to: Pukrop, e-mail: tobias.pukrop@ukr.de Keywords:...
The spatial extent of transcranial magnetic stimulation (TMS) is paramount interest for all studies employing this method. It generally assumed that the induced electric field crucial parameter to determine which cortical regions are excited. While it difficult directly measure field, one usually relies on computational models estimate distribution. Direct electrical (DES) a local brain method considered gold standard map structure-function relationships in brain. Its application typically...