A5016669084- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- Vasculitis and related conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Retinal Development and Disorders
- Autoimmune Bullous Skin Diseases
- Systemic Lupus Erythematosus Research
- Advanced Glycation End Products research
- Calpain Protease Function and Regulation
- Connexins and lens biology
- Ocular Infections and Treatments
- Olfactory and Sensory Function Studies
- Corneal surgery and disorders
- Metabolomics and Mass Spectrometry Studies
- Atherosclerosis and Cardiovascular Diseases
- Antioxidant Activity and Oxidative Stress
- Corneal Surgery and Treatments
- Nephrotoxicity and Medicinal Plants
- Sarcoidosis and Beryllium Toxicity Research
- Sympathectomy and Hyperhidrosis Treatments
- Gestational Trophoblastic Disease Studies
Charité - Universitätsmedizin Berlin
2014-2024
Freie Universität Berlin
2018-2024
Humboldt-Universität zu Berlin
2018-2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2021-2024
Klinik und Poliklinik für Augenheilkunde Universitätsklinikum Regensburg
2018-2021
Ophthalmology Clinic
2014-2019
University of Michigan
2017-2018
Volkswagen Foundation
2016
University of Göttingen
2010
Children's Medical Research Institute
2010
Glioblastoma is the most common malignant brain tumor in adults. The currently available treatments offer only a palliative survival advantage and need for effective remains an urgent priority. Activation of p53 growth suppression/apoptotic pathway one promising strategies targeting glioma cells. We show that quinoline derivative chloroquine activates suppresses cells vitro vivo orthotopic (U87MG) human glioblastoma mouse model. Induction apoptosis mechanisms underlying effects on...
Background: To report on the outcome of intravitreal brolucizumab compared to aflibercept in patients with diabetic macular edema (DME). Methods: Prospective, observational, study 35 eyes 24 a loading dose five injections 6 mg every weeks (q6w, treatment-naïve eyes) or minimum two q6w after switch (recalcitrant DME eyes), followed by treat and extend (T&E) regimen. The results were 40 31 who treated aflibercept. data obtained from Berlin Macula Registry. primary measure was change...
This study aimed to evaluate the potential of human-machine interaction (HMI) in a deep learning software for discerning malignancy choroidal melanocytic lesions based on fundus photographs.
Macular edema (ME) remains a primary cause of visual deterioration in uveitis. Visual acuity (VA) can often be maintained using corticosteroid depot systems. This study evaluated the efficacy fluocinolone acetonide (FAc) intravitreal implant (ILUVIEN®) treating non-infectious uveitis real-world data. retrospective analysis included 135 eyes subdivided into responders and non-responders. Central retinal thickness (CRT), VA, intraocular pressure (IOP) were followed over time. A significant...
To study the effectiveness and safety of anti-CD20 B-cell antibody rituximab (RTX) in treatment ocular mucous membrane pemphigoid (MMP).Retrospective analysis six MMP patients receiving RTX with or without concomitant immunosuppression. was administered as a high dose regimen (1000 mg/infusion, day 0 14/cycle). Five received more than one cycle. Main outcome measure response, defined complete remission (CR) partial (PR), monitored at 16 24 weeks. As secondary measure, drug-related adverse...
Purpose. Diabetic macular edema (DME) is the most common cause of blindness in working-age population. Spectral-domain optical coherence tomography (SD-OCT) allows detection and monitoring a detailed analysis retinal structure. Hyperreflective foci (HF) are small, circumscribed lesions on OCT, their origin yet to be determined. Our study was aimed shed light HF pathophysiology, by analyzing number location DME patients at baseline after therapy. Methods. A prospective, observational 59 eyes...
To compare the blood flow situation in primary open-angle glaucoma (POAG) and pseudoexfoliation (PXG) using optical coherence tomography angiography (OCTA).In this prospective study a total of 26 POAG 23 PXG eyes were included. All patients underwent complete ophthalmological examination including standard automated perimetry, stereoscopic photographs optic disc, peripapillary retinal nerve fibre layer analysis vascular parameters head (ONH), region macula OCTA. In addition to recorded by...
To investigate the rate and localization of graft detachment after Descemet membrane endothelial keratoplasty.Sixty-six consecutive cases operated between June August 2014 at Charité-Universitätsmedizin Berlin were examined prospectively 1 week postoperatively. A single masked observer analyzed using optical coherence tomography (OCT), rebubbling was measured. Localization correlated to incision approach. Preoperative data rebubbling.Graft occurred in more than 2 clock hours with...
Abstract Background and purpose Approximately 1% of patients with multiple sclerosis ( MS ) have uveitis, but data on the effects immunotherapies for ‐associated uveitis are scarce. The aim this study was to investigate ophthalmological outcomes in MS‐associated treated anti‐CD20 therapy. Methods A retrospective 12 eyes six refractory previous immunotherapies, conducted. Uveitis activity assessed before initiation therapy at regular follow‐up visits. Primary outcome measures were: vitreous...
To report on the short-term outcome of intravitreal brolucizumab in patients with neovascular age-related macular degeneration (nAMD). This is a prospective, interventional, monocentric study 10 eyes treatment-naïve AMD. Patients were treated according to HAWK and HARRIER trials. After loading 3 monthly injections, received an injection 12 weeks after upload (q12w) or adjusted 8 week interval (q8w), if disease activity was present upload. Main measures change central retinal thickness (CRT)...
There is early evidence of extraocular systemic signals effecting function and morphology in neovascular age-related macular degeneration (nAMD). The prospective, cross-sectional BIOMAC study an explorative investigation peripheral blood proteome profiles matched clinical features to uncover determinacy nAMD under anti-vascular endothelial growth factor intravitreal therapy (anti-VEGF IVT). It includes 46 patients stratified by the level disease control ongoing anti-VEGF treatment. Proteomic...
Purpose To investigate differences in the retinal vessel area density (VAD) on optical coherence tomography angiography (OCTA) between eyes with unilateral herpetic viral anterior uveitis (VAU) (herpes-simplex virus (HSV) and varicella-zoster (VZV)) non-affected fellow eye.
Purpose: We aimed to determine the impact of artificial sweeteners (AS), especially saccharin, on progression and treatment efficacy patients with neovascular age-related macular degeneration (nAMD) under anti-vascular endothelial growth factor (anti-VEGF-A) treatment. Methods: In a cross-sectional study involving 46 nAMD undergoing intravitreal anti-VEGF therapy, 6 AS metabolites were detected in peripheral blood using liquid chromatography - tandem mass spectrometry (LC-MS/MS). Disease...
Abstract Purpose To investigate the xenobiotic profiles of patients with neovascular age-related macular degeneration (nAMD) undergoing anti-vascular endothelial growth factor (anti-VEGF) intravitreal therapy (IVT) to identify biomarkers indicative clinical phenotypes through advanced AI methodologies. Methods In this cross-sectional observational study, we analyzed 156 peripheral blood features in a cohort 46 nAMD stratified by choroidal neovascularization (CNV) control under anti-VEGF IVT....
To evaluate the efficacy of mineralocorticoid-receptor antagonists in comparison to acetazolamide and observation treatment central serous chorioretinopathy.Retrospective, interventional cohort study on 93 patients with acute or chronic chorioretinopathy (37 patients: group, 20 antagonist 8 27 a therapy switch between both medications). Main outcome measures were change best-corrected visual acuity, subretinal fluid (SRF) volume, retinal prominence, highest prominence (HRP) at 12 weeks.HRP...
Ocular involvement is present in up to 79% of sarcoid patients. Uveitis the main ocular manifestation and presents as a chronic intraocular inflammatory condition with potentially detrimental effects on visual acuity quality life. This retrospective study was conducted explore incidence characteristics sarcoidosis single tertiary ophthalmology center. Medical records 84 patients presenting between June 2007 March 2021 were analyzed. Based “International Workshop Sarcoidosis” (IWOS) criteria,...
Zusammenfassung Entzündliche Veränderungen der Netzhautgefäße können auf ein breites Spektrum von Ursachen zurückgeführt werden. Dazu zählen Infektionen, intraokulare und systemische Autoimmunprozesse, Allgemeinerkrankungen sowie iatrogene Faktoren. Da das Endothel Retinakapillaren die innere Blut-Retina-Schranke bildet, ist eine Störung dieser Struktur unmittelbar mit Konsequenzen für den Flüssigkeitselektrolythaushalt Netzhaut verbunden. Als klinische Folgen sich Leckagen Makulaödem...
Bevacizumab, ranibizumab, and aflibercept are commonly used to treat neovascular age-related macular degeneration (nAMD). The results of various interventional, mostly randomized head-to-head studies, indicate statistical non-inferiority these three drugs. studies often interpreted as the drugs being freely interchangeable, resulting in some health systems pressure ophthalmologists preferentially use less expensive bevacizumab. This study analyzes switching from or ranibizumab bevacizumab...
Purpose: Nesfatin-1 is produced in various tissues of the body including hypothalamus. Neuroprotective properties neuropeptide hormone were recently described. The aim study was to analyze molecule as a possible biomarker POAG with neuroprotective pointing out retinal-hypothalamic axis target site and obtain molecular signature cytokines neuroinflammatory processes are key factor glaucoma development. Methods: In this study, n=35 patients moderate advanced (mean age 65.0y, IOP 13.9± 3.0mmHg)...
Crystallins are the predominant structural proteins in lens that evolutionarily related to stress proteins. There two main crystallin gene families: α-crystallins and β/γ-crystallins. α- β-crystallins were first considered be lens-specific, but recently recognized also as neuronal retinal While ocular they responsible for maintenance of transparency, their function neurons is obviously different - regulating various protective mechanisms degenerative conditions central nervous system. We...