A5014600738- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cell Adhesion Molecules Research
- Neonatal and Maternal Infections
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Platelet Disorders and Treatments
- Hemodynamic Monitoring and Therapy
- Sepsis Diagnosis and Treatment
- Inflammasome and immune disorders
- Advanced Glycation End Products research
- Kawasaki Disease and Coronary Complications
- Congenital Diaphragmatic Hernia Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Inflammatory Biomarkers in Disease Prognosis
- Phagocytosis and Immune Regulation
- Blood disorders and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Infant Nutrition and Health
- Infant Development and Preterm Care
- Angiogenesis and VEGF in Cancer
- Glycosylation and Glycoproteins Research
- Nitric Oxide and Endothelin Effects
- Retinopathy of Prematurity Studies
Ludwig-Maximilians-Universität München
2013-2024
LMU Klinikum
2007-2024
Max Planck Institute for Molecular Biomedicine
2017
Max Planck Institute of Biochemistry
2017
Harvard University
2017
Roche (United States)
2017
München Klinik
2015
Centre of Experimental Medicine of the Slovak Academy of Sciences
2010-2011
Baum Consult
2007
Massachusetts General Hospital
1992
Abstract Myeloid-related proteins (MRPs) 8 and 14 are cytosolic secreted from myeloid cells as proinflammatory mediators. Currently, the functional role of circulating extracellular MRP8/14 is unclear. Our present study identifies an autocrine player in leukocyte adhesion cascade. We show that E-selectin–PSGL-1 interaction during neutrophil rolling triggers Mrp8/14 secretion. Released turn activates a TLR4-mediated, Rap1-GTPase-dependent pathway rapid β2 integrin activation neutrophils. This...
Abstract Sphingosine-1-phosphate (S1P) participates in inflammation; however, its role leukocyte rolling is still unclear. Here we use intravital microscopy inflamed mouse cremaster muscle venules and human endothelial cells to show that S1P contributes P-selectin-dependent through receptor 3 (S1P ) Gα q , PLCβ Ca 2+ . Intra-arterial administration increases rolling, while deficiency or inhibition dramatically reduces it. Mast involved triggering also release mobilizes P-selectin Histamine...
Abstract Leukocyte recruitment is ontogenetically regulated during fetal life, with strongly impaired adhesiveness of leukocytes and endothelial cells, early development. Attenuation the immune response contributes to high rate neonatal infections, particularly in premature infants. Whereas our knowledge innate functions mature neonates growing, little known about ontogeny neutrophil recruitment. We investigated neutrophils ECs course gestation respect rolling adhesive functions. With use...
This case-control study investigates changes in microcirculation and endothelial function the acute phase of multisystem inflammatory syndrome children 3 to 6 months after onset.
Neutrophils need to penetrate the perivascular basement membrane for successful extravasation into inflamed tissue, but this process is incompletely understood. Recent findings have associated mammalian sterile 20-like kinase 1 (MST1) loss of function with a human primary immunodeficiency disorder, suggesting that MST1 may be involved in immune cell migration. Here, we shown critical regulator neutrophil during inflammation. Mst1-deficient (Mst1-/-) neutrophils were unable migrate murine...
Cyclophilin A (CyPA) induces leucocyte recruitment and platelet activation upon release into the extracellular space. Extracellular CyPA therefore plays a critical role in immuno-inflammatory responses tissue injury thrombosis activation. To date, CD147 (EMMPRIN) has been described as primary receptor mediating effects of platelets leucocytes. The for advanced glycation end products (RAGE) shares inflammatory prothrombotic properties also found to have similar ligands CD147. In this study,...
Paclitaxel encapsulated in cationic liposomes (EndoTAG-1) significantly impairs tumor growth by a significant reduction of functional microcirculation and induction endothelial cell apoptosis. The aim the study was to analyze whether platelet activation within contributes antivascular effects vascular targeting chemotherapy using EndoTAG-1. In vitro, FACS analysis revealed platelets upon treatment with vivo, A-Mel-3 tumors Syrian Golden hamsters equipped dorsal skinfold chamber preparations,...
Platelet function has been intensively studied in the adult organism. However, little is known about and hemostatic capacity of platelets developing fetus as suitable vivo models are lacking.To examine fetal platelet vivo, we generated a thrombosis model investigated light/dye-induced thrombus formation by intravital microscopy throughout gestation. We observed that significantly less unstable thrombi were formed at embryonic day (E) 13.5 compared with E17.5. Flow cytometry revealed lower...
Newborns are at high risk of developing neonatal sepsis, particularly if born prematurely. This has been linked to divergent requirements the immune system fulfill during intrauterine compared with extrauterine life. By transcriptomic analysis fetal and adult neutrophils, we shed new light on molecular mechanisms neutrophil maturation functional adaption ontogeny. We identified an accumulation differentially regulated genes within noncanonical NF-κB signaling pathway accompanied by...
Persistent pulmonary hypertension of the newborn (PPHN) is a life-threatening condition characterized by hypoxemia due to elevated vascular resistance. PPHN commonly arises secondary various underlying conditions, including infection, meconium aspiration, and respiratory distress syndrome. Management includes vasodilators, mechanical ventilation, oxygen supplementation, vasopressors, volume replacement. Stüve-Wiedemann syndrome (SWS), rare genetic disorder bone dysplasia, distress,...
Abstract Purpose After living with the COVID-19 pandemic for more than 2 years, impact of lockdown measures on preterm birth rates is inconsistent according to data from different countries. In this study, preterm-born infants during time COVID-19-related lockdowns were analyzed in a tertiary perinatal center at Munich University, Germany. Methods We number births, infants, and stillbirths before 37 weeks gestation German period compared same periods years 2018 2019 combined. Additionally,...