A5030988719- Platelet Disorders and Treatments
- Cell Adhesion Molecules Research
- Blood properties and coagulation
- Trace Elements in Health
- Cellular Mechanics and Interactions
- Systemic Lupus Erythematosus Research
- Hemoglobinopathies and Related Disorders
- Advanced Glycation End Products research
- Caveolin-1 and cellular processes
- Signaling Pathways in Disease
- Respiratory and Cough-Related Research
- Blood disorders and treatments
- Blood groups and transfusion
- Extracellular vesicles in disease
- Phytochemicals and Antioxidant Activities
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mast cells and histamine
- Ion Channels and Receptors
Universitätsklinikum Würzburg
2020-2024
University of Würzburg
2020-2024
Centre Virchow-Villermé
2019
Cyclophilin A (CyPA) induces leucocyte recruitment and platelet activation upon release into the extracellular space. Extracellular CyPA therefore plays a critical role in immuno-inflammatory responses tissue injury thrombosis activation. To date, CD147 (EMMPRIN) has been described as primary receptor mediating effects of platelets leucocytes. The for advanced glycation end products (RAGE) shares inflammatory prothrombotic properties also found to have similar ligands CD147. In this study,...
Store-operated Ca2+ entry (SOCE) is the major route of influx in platelets. The sensor stromal interaction molecule 1 (STIM1) triggers SOCE by forming punctate structures with channel Orai1 and inositol trisphosphate receptor (IP3R), thereby linking endo-/sarcoplasmic reticulum to plasma membrane. Here, we identified BAR domain superfamily member bridging integrator 2 (BIN2) as an partner STIM1 IP3R Deletion platelet BIN2 (Bin2fl/fl,Pf4-Cre mice) resulted reduced store release response all...
Megakaryocytes (MKs), the precursors of blood platelets, are large, polyploid cells residing mainly in bone marrow. We have previously shown that balanced signaling Rho GTPases RhoA and Cdc42 is critical for correct MK localization at marrow sinusoids vivo. Using conditional RhoA/Cdc42 double-knockout (DKO) mice, we reveal here dispensable process polyploidization MKs but essential cytoplasmic maturation. Proplatelet formation virtually abrogated absence leads to severe macrothrombocytopenia...
Interrogating platelets and their densely packed, highly abundant receptor landscape is key to understand platelet clotting, a process that can save lives when stopping blood loss after an injury, but also kill causing heart attack, stroke, or pulmonary embolism. The underlying distributions interactions, in particular the relevance of integrin clustering, are not fully understood because distributed αIIbβ3 receptors. This makes difficult assess even by super-resolution fluorescence...
Zinc (Zn
Megakaryocytes are large cells in the bone marrow that give rise to blood platelets. Platelet biogenesis involves megakaryocyte maturation, localization of mature close proximity sinusoids, and formation protrusions, which elongated shed within circulation. Rho GTPases play important roles platelet function. RhoA-deficient mice display macrothrombocytopenia a striking mislocalization megakaryocytes into sinusoids specific defect G-protein signaling However, role closely related protein RhoB...
<p class="first" dir="auto" id="d1370922e187">Thrombotic events remain one of the main causes death worldwide. Although several antithrombotic therapies are available, most them bear risk bleeding. Nitric oxide (NO) is an important endogenous inhibitor platelet aggregation. Recent work indicated that NO drives generation cGMP in platelets via NO-sensitive guanylyl cyclase (NO-GC) a flow/shear-sensitive manner, also referred to as mechanosensitive signaling (mechano-cGMP). In present work,...
ABSTRACT The hematopoietic-specific protein 1 (Hem1) comprises an essential subunit of the WAVE Regulatory Complex (WRC) in immune cells. WRC has a fundamental role Arp2/3 complex activation and protrusion branched actin networks motile Hem1 deficiency leads to suppression entire Defective function macrophages results loss lamellipodia migration defects. Moreover, phagocytosis, commonly accompanied by lamellipodium during cup formation, is altered null cells concerning frequency efficacy....
Abstract Interrogating small platelets and their densely packed, highly abundant receptor landscape is key to understand platelet clotting, a process that can save lives when stopping blood loss after an injury, but also kill causing heart attack, stroke or pulmonary embolism. The underlying distributions interactions, in particular the relevance of integrin clustering, are not fully understood because distributed GPIIb/IIIa receptors. This makes difficult assess even by super-resolution...
Abstract Zinc (Zn 2+ ) is considered as an important mediator for thrombosis and haemostasis. However, our understanding of the transport mechanisms that regulate Zn homeostasis in platelets limited. transporters, ZIPs ZnTs, are widely expressed eukaryotic cells. Using mice globally lacking ZIP1 ZIP3 (ZIP1/3 DKO), aim was to explore potential role these well-known transporters maintaining platelet regulation function. While ICP-MS measurements indicated unaltered overall concentrations...
ABSTRACT Megakaryocytes are large cells in the bone marrow, which give rise to blood platelets. Platelet biogenesis involves megakaryocyte maturation, localization of mature close proximity marrow sinusoids and formation protrusions, shed into circulation. Rho GTPases play important roles platelet function. RhoA-deficient mice display macrothrombocytopenia a striking mislocalization megakaryocytes specific defect G-protein signaling However, role closely related protein RhoB or platelets...