A5039313325- Platelet Disorders and Treatments
- Proteoglycans and glycosaminoglycans research
- Cell Adhesion Molecules Research
- Glycosylation and Glycoproteins Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Systemic Lupus Erythematosus Research
- Acute Ischemic Stroke Management
- Chronic Myeloid Leukemia Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Autoimmune Bullous Skin Diseases
- Blood properties and coagulation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Atherosclerosis and Cardiovascular Diseases
- Fibroblast Growth Factor Research
- Mast cells and histamine
- Cerebral Venous Sinus Thrombosis
- Sphingolipid Metabolism and Signaling
- Venous Thromboembolism Diagnosis and Management
- Neurological Disease Mechanisms and Treatments
University of Würzburg
2021-2024
Universitätsklinikum Würzburg
2021-2023
Abstract Background and Aims Glycoprotein VI (GPVI) is a platelet collagen/fibrin(ogen) receptor an emerging pharmacological target for the treatment of thrombotic thrombo-inflammatory diseases, notably ischaemic stroke. A first anti-human GPVI (hGPVI) antibody Fab-fragment (ACT017/glenzocimab, KD: 4.1 nM) recently passed clinical phase 1b/2a study in patients with acute stroke was found to be well tolerated, safe, potentially beneficial. In this study, novel humanized anti-GPVI (EMA601;...
Cerebral venous (sinus) thrombosis (CVT) is an unusual manifestation of causing severe neurological impairment and seizures
Abstract During megakaryopoiesis, megakaryocytes (MKs) undergo cellular morphological changes with strong modification of membrane composition and lipid signaling. Here, we adopt a lipid-centric multiomics approach to create quantitative map the MK lipidome during maturation proplatelet formation. Data reveal that differentiation is driven by an increased fatty acyl import de novo synthesis, resulting in anionic phenotype. Pharmacological perturbation acid phospholipid synthesis blocked...
Coordinated rearrangements of the actin cytoskeleton are pivotal for platelet biogenesis from megakaryocytes but also orchestrate key functions peripheral platelets in hemostasis and thrombosis, such as granule release, formation filopodia lamellipodia, or clot retraction. Along with profilin (Pfn) 1, thymosin β4 (encoded by Tmsb4x) is one two main G-actin-sequestering proteins within cells higher eukaryotes, its intracellular concentration particularly high that rapidly respond to external...
Ischemic stroke is among the leading causes of disability and death worldwide. In acute ischemic stroke, successful recanalization occluded vessels primary therapeutic aim, but even if it achieved, not all patients benefit. Although blockade platelet aggregation did prevent infarct progression, cerebral thrombosis as cause secondary growth has remained a matter debate. As thrombi are frequently observed after experimental thrombus-induced impairment brain microcirculation considered to...
Interrogating platelets and their densely packed, highly abundant receptor landscape is key to understand platelet clotting, a process that can save lives when stopping blood loss after an injury, but also kill causing heart attack, stroke, or pulmonary embolism. The underlying distributions interactions, in particular the relevance of integrin clustering, are not fully understood because distributed αIIbβ3 receptors. This makes difficult assess even by super-resolution fluorescence...
Effective inhibition of thrombosis without generating bleeding risks is a major challenge in medicine. Accumulating evidence suggests that this can be achieved by coagulation factor XII (FXII), as either its knock-out or animal models efficiently reduced affecting normal hemostasis. Based on these findings, highly specific inhibitors for human FXII(a) are under development. However, currently, vivo studies their efficacy and safety impeded the lack an optimized model expressing target, is,...
Abstract Interrogating small platelets and their densely packed, highly abundant receptor landscape is key to understand platelet clotting, a process that can save lives when stopping blood loss after an injury, but also kill causing heart attack, stroke or pulmonary embolism. The underlying distributions interactions, in particular the relevance of integrin clustering, are not fully understood because distributed GPIIb/IIIa receptors. This makes difficult assess even by super-resolution...
Abstract Ischemic stroke is among the leading causes of disability and death worldwide. In acute ischemic stroke, successful recanalization occluded vessels primary therapeutic aim, but even if it achieved, not all patients benefit. Although blockade platelet aggregation did prevent infarct progression, cerebral thrombosis as cause secondary growth has remained a matter debate. As thrombi are frequently observed after experimental thrombus-induced impairment brain microcirculation considered...