Volker Rudolph
A5008918690- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pulmonary Hypertension Research and Treatments
- Nitric Oxide and Endothelin Effects
- Cardiac Arrhythmias and Treatments
- Aortic Disease and Treatment Approaches
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Cardiac Fibrosis and Remodeling
- Mechanical Circulatory Support Devices
- Eicosanoids and Hypertension Pharmacology
- Cardiac Ischemia and Reperfusion
- Congenital Heart Disease Studies
- Cardiomyopathy and Myosin Studies
- Heart Failure Treatment and Management
- Coronary Interventions and Diagnostics
- Cardiac and Coronary Surgery Techniques
- Adipose Tissue and Metabolism
- Cardiac, Anesthesia and Surgical Outcomes
- Atherosclerosis and Cardiovascular Diseases
Ruhr University Bochum
2020-2025
Heart and Diabetes Center North Rhine-Westphalia
2019-2025
Bielefeld University
2024-2025
University Hospitals of the Ruhr-University of Bochum
2022-2025
University of Cologne
2013-2024
University Hospital Cologne
2012-2024
Friedrich Schiller University Jena
2024
Jena University Hospital
2003-2024
LWL-Universitätsklinikum Bochum
2022-2024
Northwestern University
2023
Recruitment and activation of polymorphonuclear neutrophils (PMNs) reflects a primary immunological response to invading pathogens has also emerged as hallmark vascular inflammation. One the principal enzymes released upon PMN is myeloperoxidase (MPO), heme protein that not only generates cytotoxic oxidants but impacts deleteriously on nitric oxide-dependent signaling cascades within vasculature. Because MPO associates with membrane PMN, we evaluated whether could function an autocrine...
Background: Current surgical and medical treatment options for severe tricuspid regurgitation (TR) are limited, additional interventional approaches required. In the present observational study, safety feasibility of transcatheter repair chronic TR with MitraClip system were evaluated. addition, effects on clinical symptoms assessed. Methods: Patients heart failure optimal treated system. Safety, defined as periprocedural adverse events such death, myocardial infarction, stroke, or cardiac...
We sought to assess the feasibility of catheter-based mitral valve repair using MitraClip system in high-surgical-risk patients with regurgitation (MR) ≥grade 3+. therapy was performed 51 consecutive [73 ± 10 years; 34 (67%) men] symptomatic functional [n = 35 (69%)] or organic MR 16 (31%)]. Mean logistic EuroSCORE 29 22%; Society Thoracic Surgeons score 15 11. Left ventricular (LV) ejection fraction 36 17%. In (69%), adverse morphology and/or severe LV dysfunction were present. implantation...
The role of catheter ablation in patients with symptomatic atrial fibrillation and end-stage heart failure is unknown. Download a PDF the Research Summary. We conducted single-center, open-label trial Germany that involved who were referred for transplantation evaluation. Patients assigned to receive guideline-directed medical therapy or alone. primary end point was composite death from any cause, implantation left ventricular assist device, urgent transplantation. A total 97 group...
Secondary (or functional) mitral regurgitation (SMR) occurs frequently in chronic heart failure (HF) with reduced left ventricular (LV) ejection fraction, resulting from LV remodelling that prevents coaptation of the valve leaflets. contributes to progression symptoms and signs HF confers worse prognosis. The management patients SMR is complex requires timely referral a multidisciplinary Heart Team. Optimization pharmacological device therapy according guideline recommendations crucial....
Severe tricuspid regurgitation (TR) is known to be associated with substantial morbidity and mortality.The authors sought study the acute outcomes of subjects treated by transcatheter edge-to-edge repair TriClip system (Abbott) in a contemporary, real-world setting.The bRIGHT (An Observational Real-World Study Evaluating Tricuspid Regurgitation Patients Treated With Abbott TriClip™ Device) postapproval prospective, single-arm, open-label, multicenter, postmarket registry conducted at 26...
Abstract Background and aims Benefit of tricuspid regurgitation (TR) correction timing intervention are unclear. This study aimed to compare survival rates after surgical or transcatheter conservative management according a TR clinical stage as assessed using the TRI-SCORE. Methods A total 2,413 patients with severe isolated functional were enrolled in TRIGISTRY (1217 conservatively managed, 551 valve surgery, 645 repair). The primary endpoint was at 2 years. Results TRI-SCORE low (≤3) 32%,...
BackgroundCurrent treatment recommendations for patients with heart failure and secondary mitral regurgitation include transcatheter edge-to-edge repair mitral-valve surgery. Data from randomized trials comparing these therapies are lacking in this patient population.MethodsIn noninferiority trial conducted Germany, who continued to have symptoms despite guideline-directed medical therapy were randomly assigned, a 1:1 ratio, undergo either (intervention group) or surgical replacement...
Abstract Background and Aims Risk stratification for mitral valve transcatheter edge-to-edge repair (M-TEER) is paramount in the decision-making process to appropriately select patients with severe secondary regurgitation (SMR). This study sought develop validate an artificial intelligence-derived risk score (EuroSMR score) predict 1-year outcomes (survival or survival + clinical improvement) SMR undergoing M-TEER. Methods An was developed from EuroSMR cohort (4172 428 treated M-TEER...
Aims Data on the prognostic impact of residual tricuspid regurgitation (TR) after transcatheter edge‐to‐edge repair (T‐TEER) are scarce. The aim this analysis was to evaluate 2‐year survival and symptomatic outcomes patients in relation TR T‐TEER. Methods results Using large European Registry Transcatheter Repair for Tricuspid Regurgitation (EuroTR registry) we investigated all‐cause mortality New York Heart Association (NYHA) functional class at follow‐up. study further identified...
Neutrophils and monocytes are centrally linked to vascular inflammatory disease, leukocyte-derived myeloperoxidase (MPO) has emerged as an important mechanistic participant in impaired vasomotor function. MPO binds transcytoses endothelial cells a glycosaminoglycan-dependent manner, binding the vessel wall is prerequisite for MPO-dependent oxidation of endothelium-derived nitric oxide (NO) impairment function animal models. In present study, we investigated whether heparin mobilizes from...
AimsNitrated fatty acids (NO 2 -FA) have been identified as endogenous anti-inflammatory signalling mediators generated by oxidative inflammatory reactions.Herein the in vivo generation of nitro-oleic acid (OA-NO ) and nitro-linoleic (LNO was measured a murine model myocardial ischaemia reperfusion (I/R) effect exogenous administration OA-NO on I/R injury evaluated. Methods resultsIn C57/BL6 mice subjected to 30 min coronary artery ligation, LNO formation observed after reperfusion, whereas...
The peroxisome proliferator-activated receptor-gamma (PPARgamma) binds diverse ligands to transcriptionally regulate metabolism and inflammation. Activators of PPARgamma include lipids anti-hyperglycemic drugs such as thiazolidinediones (TZDs). Recently, TZDs have raised concern after being linked with increased risk peripheral edema, weight gain, adverse cardiovascular events. Most reported endogenous are intermediates lipid oxidation that bind very low affinity. In contrast, nitro...
Background— Surgical aortic valve replacement in patients with small annular dimensions is challenging because they are at increased risk for prosthesis–patient mismatch and impaired outcomes. Transcatheter might be a good alternative; however, comparative data on different transcatheter heart valves missing. Methods Results— This multicenter, propensity score–matched study compared hemodynamics early clinical outcomes 246 an annulus area <400 mm 2 undergoing either self-expanding...