A5028951404- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Viral Infections and Immunology Research
- Pulmonary Hypertension Research and Treatments
- Advanced MRI Techniques and Applications
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pericarditis and Cardiac Tamponade
- Heart Failure Treatment and Management
- Cardiovascular and exercise physiology
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Sepsis Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Cardiovascular Health and Disease Prevention
- Acute Kidney Injury Research
- Cardiac electrophysiology and arrhythmias
Düsseldorf University Hospital
2017-2025
Heinrich Heine University Düsseldorf
2016-2025
Abstract Background and Aims Risk stratification for mitral valve transcatheter edge-to-edge repair (M-TEER) is paramount in the decision-making process to appropriately select patients with severe secondary regurgitation (SMR). This study sought develop validate an artificial intelligence-derived risk score (EuroSMR score) predict 1-year outcomes (survival or survival + clinical improvement) SMR undergoing M-TEER. Methods An was developed from EuroSMR cohort (4172 428 treated M-TEER...
While most patients recover from suspected acute myocarditis (sAMC) some develop progressive disease with 5-year mortality up to 20%. Recently, parametric Cardiovascular Magnetic Resonance (CMR) approaches, quantifying native T1 and T2 relaxation time, have demonstrated the ability increase diagnostic accuracy. However, prognostic implications of values in this cohort are unknown. The purpose study was investigate relevance elevated CMR sAMC. We carried out a prospective 46 sAMC defined by...
Recurrent mitral regurgitation (MR) following MitraClip has not been thoroughly investigated. We aimed to examine the predictive factors, morphology, and long-term outcome of recurrent MR after MitraClip.We assessed data from Heart Failure Network Rhineland registry August 2010 October 2018. Competing risk analyses were performed using Fine Gray model assess MR.Among 685 patients with a reduction in ≤2+, 61 developed within first 12 months. Flail leaflet (hazard ratio, 3.68; P=0.002)...
T2 mapping indicates to be a sensitive method for detection of tissue oedema hidden beyond the limits T2-weighted Cardiovascular Magnetic Resonance (CMR). However, due variability baseline values in volunteers, reference need defined. Therefore, aim study was investigate effects age and sex on quantitative with turbo gradient-spin-echo (GRASE) sequence at 1.5 T. For that reason, we studied sensitivity issues as well technical biological GRASE-derived myocardial maps. Furthermore, intra-...
The aim of this study was to determine the value T2 mapping for non-invasive assessment myocardial inflammation in different stages systolic left ventricular dysfunction dilated cardiomyopathy (DCM) comparison with endomyocardial biopsy (EMB).A total 132 subjects were enrolled between 2013 and 2016 (62 controls 70 patients DCM). All underwent CMR at 1.5 T received coronary angiogram EMB. applied standard protocols including Gradient And SpinEcho sequence (GRASE). Global relaxation time...
Mitral valve repair may lead to alterations of tricuspid regurgitation (TR).
Abstract Aims Ischaemic mitral regurgitation (MR) is a dynamic condition influenced by global and regional left ventricular remodelling as well valvular deformation. Exercise testing plays substantial role in assessing the haemodynamic relevance of MR recommended current guidelines. We aimed to assess prevalence, consequences, prognostic impact using isometric handgrip exercise. Methods results Heart failure patients with ischaemic cardiomyopathy at least mild who underwent echocardiography...
Transcatheter edge-to-edge repair of the mitral valve (M-TEER) is known for its low complication rates. However, optimal level and duration post-procedural care remain unclear. This study aimed to identify specific timeframe complications following M-TEER. We conducted a retrospective analysis 865 patients who underwent M-TEER at University Hospital Düsseldorf between August 2010 2023. Our focused on comprehensive examination all acute (1-100 h), considering time point occurrence or...
The extent of mitral regurgitation (MR) may vary depending on the haemodynamic situation; thus, exercise testing plays an important role in assessing relevance MR. We aim to assess prevalence, mechanisms, and prognostic impact exercise-induced changes MR patients with degenerative (DegMR) functional (FMR). enrolled 367 at least mild who underwent standardized echocardiography rest during handgrip exercise. Handgrip led increase by one grade or more 19% DegMR 28% FMR patients. In FMR,...
Right ventricular impairment is common among patients undergoing transcatheter edge-to-edge repair for secondary mitral regurgitation (SMR). Adherence to guideline-directed medical therapy (GDMT) heart failure poor in these patients. The aim of this study was evaluate the impact GDMT on long-term survival patient cohort. Within EuroSMR (European Registry Transcatheter Repair Secondary Mitral Regurgitation) international registry, we selected with SMR and right (tricuspid annular plane...
Mitral valve transcatheter edge-to-edge repair (M-TEER) reduces secondary mitral regurgitation (MR) in heart failure and impacts survival selected patients as demonstrated the COAPT (Cardiovascular Outcomes Assessment of MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Regurgitation) trial. However, long-term outcome data after M-TEER under real-world conditions are lacking. This study sought to assess efficacy a large registry. We analyzed significant MR undergoing...
In-hospital cardiac arrest (IHCA) is associated with high mortality and poor neurological outcomes. Our objective was to assess whether the lactate-to-albumin ratio (LAR) can predict outcomes in patients after IHCA. We retrospectively screened 75,987 hospitalised at a university hospital between 2015 2019. The primary endpoint survival 30-days. Neurological were assessed 30 days using cerebral performance category scale. 244 IHCA return of spontaneous circulation (ROSC) included this study...
Abstract Aims In atrial functional mitral regurgitation (aFMR), a considerable proportion of patients displays discrepancy between symptoms and echocardiographic findings at rest. Exercise testing plays substantial role in assessing the haemodynamic relevance (MR) is recommended by current guidelines. Here, we aimed to assess prevalence, extent, prognostic impact exercise-induced changes with aFMR. Methods results Patients least mild MR who underwent handgrip exercise echocardiography...
In terms of pathophysiology, tricuspid regurgitation (TR) and right ventricular (RV) function are linked to each other.This study sought evaluate RV-pulmonary artery (PA) coupling its impact on clinical outcomes TR in patients undergoing mitral transcatheter edge-to-edge repair (TEER).We calculated RV-PA ratios TEER from August 2010 March 2019 by dividing the annular plane systolic excursion (TAPSE) echocardiographic estimated PA pressure (PASP). was graded as none/trace, mild, moderate, or...
Functional mitral regurgitation (MR) is the second most common valvular heart disease worldwide and increasing with age. The present study investigates gender distribution 1 year prognosis of older patients (≥65 years) pharmacologically treated MR in a real-world population moderate to severe functional MR.This single-centre retrospective observational cohort included 243 medically from 2014 2020. Echocardiography was performed at baseline. combined endpoint hospitalization due failure...
<b><i>Background:</i></b> Exercise intolerance in heart failure with reduced ejection fraction (HFrEF) or preserved (HFpEF) results from both cardiac dysfunction and skeletal muscle weakness. Respiratory restrictive ventilation disorder may be present irrespective of left ventricular might mediated by circulating pro-inflammatory cytokines. <b><i>Objective:</i></b> To determine lung respiratory function patients HFrEF/HFpEF to its associations...
Abstract Background Reliable risk scores in patients undergoing transcatheter edge-to-edge mitral valve repair (TMVR) are lacking. Heart failure is common these patients, and derived from heart populations might help stratify TMVR patients. Methods Consecutive three Centers were enrolled to investigate the association of “Get with Guidelines Failure Risk Score” (comprising variables systolic blood pressure, urea nitrogen, sodium, age, rate, race, history chronic obstructive lung disease)...
Background Optimizing risk stratification in patients undergoing transcatheter mitral valve repair is an ongoing challenge. The Mitral Regurgitation International Database (MIDA) score represents a user-friendly mortality tool that validated on large-scale registry of with degenerative regurgitation (MR). We here assessed the potential benefit MIDA for functional or MR repair. Methods and Results In total, 680 MitraClip implantation were stratified according to tertiles into low (0-7),...
The objective of this study was to assess the prognostic value Model for End-stage Liver Disease (MELD)-XI score in patients undergoing PMVR with MitraClip system.MELD-XI score, which originally developed assessment advanced liver disease, has been reported as a predictor outcome heart failure patients.A total 192 consecutive percutaneous mitral valve repair (PMVR) were included into final analysis. MELD-XI calculated on day procedure and categorized three groups based compared regards...