A5011157058- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Cardiac and Coronary Surgery Techniques
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Fire effects on ecosystems
- Diagnosis and Treatment of Venous Diseases
- Clinical practice guidelines implementation
- Acute Myocardial Infarction Research
- Potassium and Related Disorders
- Heart Failure Treatment and Management
- Neuroscience and Neural Engineering
- Vascular Procedures and Complications
- Cardiac Arrhythmias and Treatments
- Viral Infections and Vectors
- Antiplatelet Therapy and Cardiovascular Diseases
- Hormonal Regulation and Hypertension
- Apelin-related biomedical research
- Ultrasound in Clinical Applications
- Viral Infections and Outbreaks Research
- Ion channel regulation and function
Krankenhaus Porz am Rhein
2021-2024
Witten/Herdecke University
2021-2024
Lukaskrankenhaus
2016-2022
Klinikum Rheine
2021
Paracelsus Medical University
2012-2013
University of Cologne
2007-2012
Abstract Background and Aims Risk stratification for mitral valve transcatheter edge-to-edge repair (M-TEER) is paramount in the decision-making process to appropriately select patients with severe secondary regurgitation (SMR). This study sought develop validate an artificial intelligence-derived risk score (EuroSMR score) predict 1-year outcomes (survival or survival + clinical improvement) SMR undergoing M-TEER. Methods An was developed from EuroSMR cohort (4172 428 treated M-TEER...
BackgroundIncreased activity of single ventricular L-type Ca2+-channels (L-VDCC) is a hallmark in human heart failure. Recent findings suggest differential modulation by several auxiliary β-subunits as possible explanation.Methods and ResultsBy molecular functional analyses murine ventricles, we find that enhanced L-VDCC accompanied altered expression pattern β-subunit gene products. In HEK293-cells show coexpression cardiac β-subunits: Unlike β1 or β3 isoforms, β2a β2b induce high-activity...
Background: Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. The ReninAngiotensin-Aldosterone-System plays a major role for atrial structural and electrical remodelling. Recently elevated aldosterone levels have been suggested to increase risk development of AF. Methods: Rats were treated with by means an osmotic minipump (0.5µg/h) over period 4 weeks. AF was induced transesophageal burst pacing. Action potentials (AP) recorded from left preparations...
We aimed to compare indirect mitral annuloplasty using the Carillon Mitral Contour System and edge-to-edge repair via MitraClip in atrial functional regurgitation (aFMR).In patients with left ventricular dilation, both are effective reducing regurgitation, while no clinical trial has compared interventional methods aFMR.In a retrospective single-center analysis, 41 aFMR underwent either valve (MitraClip group, n = 20) or (Carillon 21).Both treatment groups showed high procedural success...
Background Atrial fibrillation (AF) triggers atrial remodeling, impacting function and ablation efficacy. This remodeling leads to cardiomyopathy dilatation, linked mitral regurgitation, forming functional regurgitation (aFMR). Our study explores the relationship between early-stage-aFMR electrical architecture, focusing on left bipolar voltage low-voltage areas (LVAs) in AF patients. Methods We enrolled 282 patients undergoing redo-PVI after recurrence post-PVI. Echocardiography was...
Abstract Background Transcatheter edge‐to‐edge repair (TEER) has emerged to address symptomatic atrial functional mitral regurgitation (aFMR) in patients who are at high operative risk. Aims No clinical data is available on the impact of residual (MR) following TEER aFMR compared ventricular MR (vFMR). Methods In MITRA‐PRO registry, 846 with FMR and MitraScore assessment for quantification were included (722 vFMR 124 aFMR). Results Compared similar procedural results regard found (MitraScore...
Abstract Objectives Coronary sinus (CS) based mitral annuloplasty using the Carillon device is effective in reducing functional valve regurgitation (FMR). However, this positive effect might be dependent on relation between CS and annulus. Background Computed tomography (CT) assessment prior to interventions an emerging technique optimize patient selection. Methods In a retrospective analysis 30 patients underwent implantation received CT‐angiography percutaneous repair. Patients were...
Objectives The presence of coronary artery disease (CAD) in patients hospitalised with paroxysmal or first diagnosed atrial fibrillation (AF) has major implications for antithrombotic therapy and cardiovascular event rate. Coronary CT angiography (CCTA) is a feasible tool to identify concealed CAD. We aimed evaluate the diagnostic role early CCTA AF. Methods In 5-year single-centre retrospective analysis, 566 AF who underwent were enrolled investigate Results AF, revealed CAD (coronary...
Coronary sinus (CS) based mitral annuloplasty using the Carillon device could be limited by compromise of left circumflex artery (Cx).Computed tomography (CT) might a feasible tool for preprocedural planning indirect valve annuloplasty.In retrospective analysis, 25 patients underwent implantation and received CT-angiography (CTA) analysis prior to CS percutaneous repair. We used approach with CTA intraprocedural coronary angiography (CSA) measurements determine Cx distance at occlusion or...
Cardiac tamponade is a rare but life-threatening complication of cardiac interventions. Despite prompt pericardiocentesis, clinical management can be challenging and sometimes haemodynamic stabilisation difficult to achieve. Intra-pericardial thrombin injection after pericardiocentesis promotes haemostasis acts as sealing agent, previously described for left ventricular free-wall rupture. We aimed evaluate intra-pericardial bailout strategy pericardial following percutaneous interventions.In...
Abstract Background The MITRA-PRO registry revealed residual mitral regurgitation (MR) to be an important predictor of survival following transcatheter edge-to-edge repair (TEER). Intraprocedural MR assessment using 3D-Vena Contracta Area (VCA) might a feasible tool guide TEER procedures. study aimed assess the impact assessed by 3D-VCA on 1-year mortality. Methods 823 patients with quantification in registry, were included this study. mortality, NYHA classification and major adverse events...
ABSTRACT Background Right ventricular‐to‐pulmonary artery (RV‐PA) coupling is an important predictor of long‐term survival following transcatheter edge‐to‐edge repair. However, its impact on in patients undergoing indirect mitral annuloplasty unknown. The study aimed to assess the baseline RV‐PA heart failure patients. Methods Patients were classified according coupling: TAPSE (tricuspid annular plane systolic excursion)/PASP (pulmonary pressure) > 0.55 (group 1), ≤ ≥ 0.32 2) and 3)....
Figure 1. Imaging following unsuccessful Carillon device implantation. A) Transoesophageal echocardiography (TEE) at baseline, post implantation (post implant) and nine-month follow-up (9-mo FU). B) Tracking the (yellow line). C) MVA to planes showing localisation of superior MVA. D) Aortic root line); AVP: aortic valve prosthesis; CS: coronary sinus (blue MVA: mitral annulus (red E) Left: topographical model indicating a distance 10.1 mm angle 18.3°. Right: prosthesis, plane vector ...
Background: Infective endocarditis (IE) following mitral valve edge-to-edge repair is a rare complication with high mortality. Case summary: A 91-year-old male patient was admitted to intensive care unit sepsis due urinary tract infection after insertion of catheter by the outpatient urologist. Two weeks ago, discharged from hospital successful transcatheter (TEER) using PASCAL Ace device. The initially withdrawn blood revealed repeatedly Proteus mirabilis bacteremia as causal for infection....
Transcatheter edge-to-edge repair (TEER) has emerged to address severe mitral and tricuspid valve regurgitation in patients who are at high perioperative risk for open-heart surgery. No clinical data is available continuous left right atrial pressure monitoring using the steerable guiding catheter (SGC) during TEER. In a prospective single-center study, 40 with (n = 20) or underwent TEER registration of via SGC. All had successful PASCAL Ace system, while was monitored continuously...
We aimed to investigate the anatomical relationship of coronary sinus (CS) and mitral valve annulus (MVA) in patients with or without functional regurgitation (FMR) using a multislice CT (MSCT) software determine (a) distance angle both CS MVA plane (b) geometry.A total 215 MSCT topography evaluation were enrolled this retrospective study.This patient cohort included 145 FMR (67.4%, ≤ 1+) 70 (32.6%) clinically relevant (FMR ≥ 2+). Distance angulation planes highly variable. In all groups, no...
Abstract Background Duration and dosage of thrombolysis for ultrasound-assisted catheter-directed (UACDT) in patients with intermediate high-risk pulmonary embolism remain controversial treatment protocols vary. Case summary A 58-year-old female patient suffered from a right-sided urolithiasis. The clinical course was complicated by an [pulmonary severity index (PESI) score 108 points simplified PESI ≥1] bilateral proximal thrombus significant right heart dysfunction. response team (PERT)...