A5009967071- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Blood Pressure and Hypertension Studies
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Cardiac pacing and defibrillation studies
- Radiation Dose and Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Structural Anomalies and Repair
- Migraine and Headache Studies
- Acute Myocardial Infarction Research
- Cardiovascular Health and Disease Prevention
- Cardiac Health and Mental Health
- Sodium Intake and Health
- Cardiac Imaging and Diagnostics
- Heart rate and cardiovascular health
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Vascular Procedures and Complications
- Takotsubo Cardiomyopathy and Associated Phenomena
- Digital Radiography and Breast Imaging
- Cardiovascular Issues in Pregnancy
- Congenital Heart Disease Studies
Paracelsus Medical University
2012-2024
University of Salzburg
2013-2024
Universitätskliniken Salzburg
2019
Salzburger Landeskliniken
2015
University of Cologne
2002-2013
Unfallkrankenhaus Salzburg
2013
Maastricht University
2012
Amsterdam UMC Location University of Amsterdam
2012
Paracelsus Medizinische Privatuniversität
2012
Centrum für Integrierte Onkologie
2011
Background— Hypertension is associated with impaired glucose metabolism and insulin resistance. Chronic activation of the sympathetic nervous system may contribute to either condition. We investigated effect catheter-based renal denervation on blood pressure control in patients resistant hypertension. Methods Results— enrolled 50 therapy-resistant Thirty-seven underwent bilateral denervation, 13 were assigned a group. Systolic diastolic pressures, fasting glucose, insulin, C peptide,...
Background— Functional mitral regurgitation (FMR), a well-recognized component of left ventricular remodeling, is associated with increased morbidity and mortality in heart failure patients. Percutaneous annuloplasty has the potential to serve as therapeutic adjunct standard medical care. Methods Results— Patients dilated cardiomyopathy, moderate severe FMR, an ejection fraction <40%, 6-minute walk distance between 150 450 m were enrolled CARILLON Mitral Annuloplasty Device European Union...
<h3>Objective:</h3> To evaluate the feasibility and safety of home monitoring chronic heart failure (CHF) patients using acoustic wireless communication with an implant directly measuring pulmonary artery (PA) pressures. <h3>Design:</h3> The PAPIRUS (Pulmonary Artery Pressure by Implantable device Responding to Ultrasonic Signal) II trial was a prospective, multicentre phase I study. <h3>Patients:</h3> 31 CHF in New York Heart Association class III-IV. <h3>Interventions:</h3> Implantation...
Summary Introduction Percutaneous coronary intervention is a well-established revascularization strategy for patients with artery disease. The safety and feasibility of performing these procedures on same-day discharge basis selected has been studied in large number mostly nonrandomized trials. An up to date literature review should focus trials radial access, representing the current standard Austria other European countries. Methods aim this consensus statement most recent evidence...
The hyperpolarization-activated cyclic nucleotide-gated (HCN) current I(f)/I(HCN) is generally thought to be carried by Na(+) and K(+) under physiological conditions. Recently, Ca(2+) influx through HCN channels has indirectly been postulated. However, direct functional evidence of permeation still lacking.To possibly provide I(HCN)/I(f), we performed inside-out cell-attached single-channel recordings heterologously expressed native rat human I(f), since Ca(2+)-mediated currents may not...
Background: Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. The ReninAngiotensin-Aldosterone-System plays a major role for atrial structural and electrical remodelling. Recently elevated aldosterone levels have been suggested to increase risk development of AF. Methods: Rats were treated with by means an osmotic minipump (0.5µg/h) over period 4 weeks. AF was induced transesophageal burst pacing. Action potentials (AP) recorded from left preparations...
Baroreflex activation therapy (BAT) by electrical stimulation of baroreceptors at the carotid sinus is a promising therapeutic approach to reduce elevated blood pressure (BP). To assess efficacy long-term BAT, we investigated acute BP alterations after device deactivation and reactivation (on/off effects) in patients on chronic as well reductions.Resistant hypertension (n = 17) were enrolled an open-label, single-arm evaluation unilateral BAT exclusion secondary hypertension. Initial...
BACKGROUND: Limited information is available on the comparative efficacy and safety of different stent platforms in patients at high bleeding risk undergoing an abbreviated dual antiplatelet therapy duration after percutaneous coronary intervention (PCI). The aim this study was to compare effectiveness biodegradable-polymer sirolimus-eluting with durable-polymer zotarolimus-eluting receiving 1 month PCI. METHODS: Bioflow-DAPT Study international, randomized, open-label trial conducted 52...
In embryonic stem (ES) cell-derived cardiomyocytes, spontaneous Ca 2+ sparks representing release through ryanodine receptor (RyR) channels were characterized and correlated to the expression of RyRs as well load sarcoplasmic reticulum (SR). very early developmental stage (VEDS) cardiac precursor cells, global intracellular concentration ([Ca ] i ) fluctuations occurred, whereas contractions absent. stages (EDS), obvious. During further differentiation late (LDS) a marked increase in...
Hyperpolarization-activated cation (HCN) channels give rise to an inward current with similar but not identical characteristics compared the pacemaker (I(f)), suggesting that HCN channel function is modulated by regulatory beta-subunits in native tissue. KCNE2 has been proposed serve as a beta-subunit of channels; however, available data remain contradictory. To further clarify this situation, we therefore analyzed effect on whole cell currents, single properties, and membrane protein...
Hyperpolarization-activated, cyclic nucleotide sensitive (HCN) channels underlie the pacemaker current I(f), which plays an essential role in spontaneous cardiac activity. HCN channel subunits (HCN1-4) are believed to be modulated by additional regulatory proteins, still have identified. Using biochemistry, molecularbiology and electrophysiology methods we demonstrate a protein-protein interaction between HCN2 K(+) regulator protein 1, named KCR1. In coimmunoprecipitation experiments show...
Percutaneous coronary intervention is a well-established revascularization strategy for patients with artery disease. Recent technical advances such as radial access, third generation drug-eluting stents and highly effective antiplatelet therapy have substantially improved the safety profile of procedures. Despite several practice guidelines clear patient preference early hospital discharge, percentage procedures performed in an outpatient setting Austria remains low, mostly due to concerns.
Objectives. Reports of testosterone effects on cardiovascular morbidity remain contradictory. Besides modulating risk factors recent evidence indicates direct actions cardiac tissue. However, the impact human L-type calcium channels that play a central role in electro-mechanical coupling is unknown. Methods and Results. Human ventricular myocytes were isolated from patients undergoing heart transplantation. Patch-clamp experiments whole-cell configuration performed to evaluate effect...
Prediabetes is frequently underdiagnosed and undertreated, yet it poses significant cardiovascular risks. This study investigates the impact of prediabetes on short- long-term survival outcomes in patients who experienced ST-elevation myocardial infarction (STEMI).