A5054297033- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Viral Infections and Immunology Research
- Cardiac electrophysiology and arrhythmias
- Cardiac Valve Diseases and Treatments
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Cardiovascular Effects of Exercise
- Atrial Fibrillation Management and Outcomes
- Cardiomyopathy and Myosin Studies
- Eosinophilic Disorders and Syndromes
- Cardiovascular and exercise physiology
- Heart rate and cardiovascular health
- Pulmonary Hypertension Research and Treatments
- SARS-CoV-2 and COVID-19 Research
- Mechanical Circulatory Support Devices
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Ocular Diseases and Behçet’s Syndrome
- Cardiac Structural Anomalies and Repair
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Health and Mental Health
Universitätsklinikum des Saarlandes
2006-2024
Saarland University
2003-2024
Klinikum Braunschweig
2024
cts CaritasKlinikum Saarbrücken
2011-2023
Klinikum Saarbrücken
2012-2021
Amphia Ziekenhuis
2011
University of Tübingen
2010
Robert Bosch Hospital
2010
Centrum für Integrierte Onkologie
2009
Universitätsklinikum Tübingen
2008
Background— The objective of this study was to identify the prognostic indicators in patients with suspected myocarditis who underwent endomyocardial biopsy. Methods and Results— Between 1994 2007, 181 consecutive (age, 42±15 years) clinically viral were enrolled followed up for a mean 59±42 months. Endomyocardial biopsies studied inflammation histological (Dallas) immunohistological criteria. Virus genome detected by polymerase chain reaction. primary end point time cardiac death or heart...
Background— Endomyocardial biopsy (EMB) represents the gold standard for diagnosing myocarditis and nonischemic cardiomyopathies. This study focuses on risk of complications respective diagnostic performance left ventricular (LV), right (RV), or biventricular EMB in patients with suspected and/or cardiomyopathy unknown origin. Methods Results— In this 2-center study, 755 clinically (n=481) origin including those infiltrative connective tissue disease (n=274) underwent either selective LV-EMB...
AimsSerological analyses of viral infection in suspected myocarditis are still widely used, although convincing evidence for their value is lacking. We determined prospectively the diagnostic virus serology comparison with endomyocardial biopsy (EMB) including genome detection and immunohistochemistry patients clinically myocarditis.
In DDD‐pacemaker patients with high degree A V block, Doppler echocardiography of transmitral blood flow can be used to find the individually optimal AV delay (AVO) for left heart synchronization. This study tried validate a method (ECHO) recently proposed optimize ventricular filling by comparing it stroke volume data derived from impedance cardiography (ICG). It should further elucidated if optimizing (AVD) means this is superior fixed AVD settings and which differential...
Background— Residual/recurrent mitral valve regurgitation is observed in 30% after undersized ring annuloplasty (RING) for ischemic (IMR). RING addresses primarily annular dilatation but does not correct severe leaflet tethering attributable to papillary muscle (PM) displacement. We proposed adjunctive PM repositioning under transesophageal echocardiography (TEE) guidance the loaded beating heart using a transventricular suture (STRING). Methods and Results— Patients with tenting height ≥10...
COVID-19 comprises several severity stages ranging from oligosymptomatic disease to multi-organ failure and fatal outcomes. The mechanisms why is a mild in some patients progresses severe often with respiratory are not known. Biomarkers that predict the course of urgently needed. aim this study was evaluate large spectrum established laboratory measurements.Patients prospective PULMPOHOM CORSAAR studies were recruited comprised 35 COVID-19, 23 conventional pneumonia, 28 control undergoing...
Carvedilol but not metoprolol exhibits persistent binding to beta-adrenergic receptors (beta-ARs) even after washout in cell culture experiments. Here, we determined the significance of this phenomenon on human beta-ARs vitro and vivo.Experiments were conducted atrial trabeculae (n=8 10 per group). In presence metoprolol, isoproterenol potency was reduced compared with controls (P<0.001). carvedilol, identified 2 distinct sites high (36+/-6%; -8.8+/-0.4 log mol/L) low affinity (-6.5+/-0.2...
AimsThe European cardiac resynchronization therapy (CRT) survey is a joint initiative taken by the Heart Failure Association and Rhythm of Society Cardiology with primary objective describing current practice associated CRT implantations. The results demonstrated that substantial number implantations took place in patients without conventional guideline indications. We investigated whether volume implants per centre was determinant propensity to use devices for 'off-label'
Hughes-Stovin syndrome (HSS) is a systemic vasculitis characterized by widespread venous/arterial thrombosis and pulmonary artery aneurysms (PAAs), which associated with serious morbidity mortality. All fatalities reported in HSS resulted from unpredictable fatal suffocating hemoptysis. Therefore, it necessary to recognize complications at an early stage of the disease.The aims this study are develop reference atlas images depicting characteristic features computed tomography angiography...