A5027380676- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Cardiac and Coronary Surgery Techniques
- Aortic Disease and Treatment Approaches
- Infective Endocarditis Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Cardiovascular Function and Risk Factors
- Organ Transplantation Techniques and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Renal Transplantation Outcomes and Treatments
- Cardiac Ischemia and Reperfusion
- Infectious Aortic and Vascular Conditions
- Heart Failure Treatment and Management
- Congenital Heart Disease Studies
- Fuel Cells and Related Materials
- 3D Printing in Biomedical Research
- Viral Infections and Immunology Research
- Coronary Interventions and Diagnostics
- Peroxisome Proliferator-Activated Receptors
- Aortic aneurysm repair treatments
- Cardiac pacing and defibrillation studies
West German Heart and Vascular Center Essen
2024-2025
RWTH Aachen University
2023-2025
Universitätsklinikum Aachen
2023-2025
Essen University Hospital
2024-2025
Heinrich Heine University Düsseldorf
2015-2024
University of Duisburg-Essen
2024
Düsseldorf University Hospital
2015-2024
Hochschule Düsseldorf University of Applied Sciences
2020-2021
E Ink (South Korea)
2021
Centrum kardiovaskulární a transplantační chirurgie
2018
Background: Cardiac surgery often represents the only treatment option in patients with infective endocarditis (IE). However, IE may lead to a sudden release of inflammatory mediators, which is associated postoperative organ dysfunction. We investigated effect hemoadsorption during on Methods: This multicenter, randomized, nonblinded, controlled trial assigned undergoing cardiac for (integration CytoSorb cardiopulmonary bypass) or control. The primary outcome (change sequential failure...
Surgical repair of congenital and acquired cardiac defects may be enhanced by the use autologous bioengineered muscle grafts. These tissue-engineered constructs are not optimal in their formation function. We hypothesized that a mechanical stretch regimen applied to human heart cells were seeded on three-dimensional gelatin scaffold (Gelfoam) would improve tissue enhance graft strength.Heart from children undergoing Tetralogy Fallot isolated cultured. Heart gelatin-matrix scaffolds subjected...
Background— Secreted factors from epicardial adipose tissue (EAT) have been implicated in the development of cardiomyocyte dysfunction. This study aimed to assess whether alterations secretory profile EAT patients with type 2 diabetes mellitus (DM2) affect contractile function and insulin action cardiomyocytes. Methods Results— Contractile were analyzed primary adult rat cardiomyocytes incubated conditioned media (CM) generated explants biopsies obtained without DM2. CM subcutaneous...
Decellularized cardiac extracellular matrix (ECM) has been introduced as a template for tissue engineering, providing the advantages of prevascularized scaffold that mimics native micro- and macroarchitecture to degree difficult achieve with synthetic materials. Nonetheless, decellularization protocols used create acellular myocardial scaffolds vary widely throughout literature. In this study we performed direct comparison three previously described while introducing evaluating novel,...
Context Adipokines are linked to the development of cardiovascular dysfunction in type 2 diabetes (DM2). In DM2-patients, circulating levels omentin-1, an adipokine preferentially expressed epicardial adipose tissue, decreased. This study investigated whether omentin-1 has a cardioprotective function. Methods Omentin-1 plasma and cardiac fat depots were determined DM2-patients versus controls. Moreover, relation between function was examined men with uncomplicated DM2. Finally, we could...
Although the biological importance of exosomes has recently gained an increasing amount scientific and clinical attention, much is still unknown about their complex pathways, bioavailability diverse functions in health disease. Current work focuses on presence behavior (in vitro as well vivo) context different human disorders, especially fields oncology, gynecology cardiology. Unfortunately, neither a consensus regarding gold standard for exosome isolation exists, nor there agreement such...
Stem cell-based cardiac tissue engineering is a promising approach for regenerative therapy of the injured heart. At present, small number stem cell-derived cardiomyocytes that can be obtained using current culture and enrichment techniques represents one key limitations development functional bioartificial (BCT). We have addressed this problem by construction novel bioreactor with features larger systems enables generation in situ monitoring miniaturized BCTs. BCTs were generated from rat...
Hülsmann J, Grün K, El Amouri S, Barth M, Hornung Holzfuß C, Lichtenberg A, Akhyari P. Transplantation material bovine pericardium: biomechanical and immunogenic characteristics after decellularization vs. glutaraldehyde‐fixing. Xenotransplantation 2012; 19: 286–297. © 2012 John Wiley & Sons A/S. Abstract: Background: Today, pericardium (BP) is extensively investigated as a biomaterial for the generation of various bioimplants. But despite commercial distribution, development methods...
Enhanced activin A release from epicardial adipose tissue (EAT) has been linked to the development of cardiac dysfunction in type 2 diabetes (T2D). This study examined whether inhibition insulin action induced by adipokines cardiomyocytes can be ascribed alterations miRNA expression.Expression levels miRNAs were assessed real-time PCR primary adult rat (ARC) exposed conditioned media generated EAT biopsies (CM-EAT) patients with and without T2D. CM-EAT-T2D altered expression eight ARC vs....
Extracorporeal life support (ECLS) is a promising therapeutic option for patients with refractory cardiogenic shock. However, as the mortality rate still remains high, there need early outcome parameters reflecting therapy success or futility. Therefore, we investigated whether liver enzyme levels could serve prognostic markers ECLS. The present study retrospective single-center cohort study. Adult >18 years of age who received ECLS between 2011 and 2018 were included. Bilirubin,...
Abstract Recreating human tissues and organs in the petri dish to establish models as tools biomedical sciences has gained momentum. These can provide insight into mechanisms of physiology, disease onset, progression, improve drug target validation, well development new medical therapeutics. Transformative materials play an important role this evolution, they be programmed direct cell behavior fate by controlling activity bioactive molecules material properties. Using nature inspiration,...
Biohybrid tissue-engineered vascular grafts (TEVGs) promise long-term durability due to their ability adapt hosts' needs. However, the latter calls for sensitive non-invasive imaging approaches longitudinally monitor functionality, integrity, and positioning. Here, we present an approach comprising labeling of non-degradable degradable TEVGs' components in vitro vivo monitoring by hybrid