A5067606080- Characterization and Applications of Magnetic Nanoparticles
- Nanoparticle-Based Drug Delivery
- Hydrogels: synthesis, properties, applications
- Coronary Interventions and Diagnostics
- Advanced Polymer Synthesis and Characterization
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Health and Disease Prevention
- Electrospun Nanofibers in Biomedical Applications
- Geomagnetism and Paleomagnetism Studies
- Aortic Disease and Treatment Approaches
- Collagen: Extraction and Characterization
- Nanocomposite Films for Food Packaging
- Ultrasound and Hyperthermia Applications
- Wound Healing and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Nanopore and Nanochannel Transport Studies
- Advanced biosensing and bioanalysis techniques
- Iron Metabolism and Disorders
- Polymer Nanocomposite Synthesis and Irradiation
- Iron oxide chemistry and applications
- Polymer crystallization and properties
- Infectious Aortic and Vascular Conditions
- Polymer Nanocomposites and Properties
- Mass Spectrometry Techniques and Applications
- Photopolymerization techniques and applications
RWTH Aachen University
2017-2024
Universitätsklinikum Aachen
2020
Sharif University of Technology
2010
Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and particle (MPI), as well fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from polydisperse starting formulation, synthesized using the routinely employed co-precipitation technique. Transmission electron microscopy, dynamic light scattering nanoparticle tracking analyses show that fractions obtained upon...
Abstract Aims (Ultra) Small superparamagnetic iron oxide nanoparticles, (U)SPIO, are widely used as magnetic resonance imaging contrast media and assumed to be safe for clinical applications in cardiovascular disease. As safety tests largely relied on normolipidaemic models, not fully representative of the setting, we investigated impact (U)SPIOs disease-relevant endpoints hyperlipidaemic models atherosclerosis. Methods results RAW264.7 foam cells, exposed vitro ferumoxide (dextran-coated...
Biohybrid tissue-engineered vascular grafts (TEVGs) promise long-term durability due to their ability adapt hosts' needs. However, the latter calls for sensitive non-invasive imaging approaches longitudinally monitor functionality, integrity, and positioning. Here, we present an approach comprising labeling of non-degradable degradable TEVGs' components in vitro vivo monitoring by hybrid
Abstract This study was performed to evaluate the properties of poly(vinyl alcohol) (PVA), gelatin, and PVA–gelatin dispersions films enriched with Zataria multiflora essential oil (ZO). The results reveal that ζ potential, particle size, viscosity values antioxidant antibacterial activities changed significantly addition ZO polymer matrix. Changes in suggested presence interactions between PVA or gelatin ZO. Such could affect mechanical water‐barrier films. induced remarkable decreases...
Tissue-engineered vascular grafts (TEVGs) with the ability to grow and remodel open new perspectives for cardiovascular surgery. Equipping TEVGs synthetic polymers biological components provides a good compromise between high structural stability adaptability. However, imaging approaches control grafts' integrity, physiological function, remodeling during entire transition late in vitro maturation early vivo engraftment are mandatory clinical implementation. Thus, comprehensive molecular...
Abstract Novel dual‐responsive hydrogels of semi‐interpenetrating polymer networks (semi‐IPNs) based on temperature‐sensitive N ‐isopropylacrylamide (NIPAA) and pH‐sensitive ‐ethylmaleamic acid (NEMA) monomers sodium alginate were synthesized using free‐radical polymerization in the presence , ′‐methylenebisacrylamide as a crosslinker. Stimuli‐responsive properties semi‐IPN showed remarkable sensitivity to both temperature pH without limitation NEMA content. Doxorubicin hydrochloride (DOX)...
Riboflavin carrier protein (RCP) and riboflavin transporters (RFVTs) have been reported to be highly overexpressed in various cancer cells. Hence, targeting RCP RFVTs using may enhance tumor accumulation internalization of drug delivery systems. To test this hypothesis, butyl-based 3-arm peptostar polymers were synthesized consisting a lysine core (10 units per arm) sarcosine shell (100 arm). The end groups the arms successfully modified with Cy5.5 fluorescent dye, respectively. While...
Objective.Magnetic particle imaging (MPI) visualizes the spatial distribution of magnetic nanoparticles. MPI already provides excellent temporal and good resolution, however, to achieve translation into clinics, further advances in fields sensitivity, image reconstruction tracer performance are needed. In this work, we propose a novel concept enhance signal resolution by purely passive receive coil insert for preclinical system.Approach.The dual resonator (pDCR) frequency-selective...
Aim of this study is to evaluate whether magnetic particle imaging (MPI) capable measuring velocities occurring in the coronary arteries and compute flow reserve (CFR) a canonical phantom as preliminary study.For basic velocity measurements, circulation was designed containing replaceable glass tubes with three varying inner diameters, matching coronary-vessel diameters. Standardised boluses superparamagnetic-iron-oxide-nanoparticles were injected visualised by MPI. Two image-based...