A5039689260- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- Antimicrobial agents and applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Carbon and Quantum Dots Applications
- Antimicrobial Peptides and Activities
- Bacterial biofilms and quorum sensing
- Photochromic and Fluorescence Chemistry
- Cancer, Hypoxia, and Metabolism
- Photodynamic Therapy Research Studies
- Dendrimers and Hyperbranched Polymers
- Boron Compounds in Chemistry
- Streptococcal Infections and Treatments
- Bacterial Infections and Vaccines
- Advanced Drug Delivery Systems
- Cancer Research and Treatments
- Biopolymer Synthesis and Applications
- Extracellular vesicles in disease
- Luminescence and Fluorescent Materials
- Bone Tissue Engineering Materials
- Hepatocellular Carcinoma Treatment and Prognosis
- Advancements in Transdermal Drug Delivery
- Reproductive tract infections research
University of Palermo
2016-2024
Fondazione Roma
2024
Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and particle (MPI), as well fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from polydisperse starting formulation, synthesized using the routinely employed co-precipitation technique. Transmission electron microscopy, dynamic light scattering nanoparticle tracking analyses show that fractions obtained upon...
There are few therapeutic options to simultaneously tackle Staphylococcus aureus and Pseudomonas aeruginosa, two of the most relevant nosocomial antibiotic-resistant pathogens responsible for implant, catheters wound severe infections. The design synthesis polymers with inherent antimicrobial activity have gained increasing attention as a safe strategy treat multi-drug-resistant microbes. Here, we tested new polymeric derivative glycopolypeptide architecture (PAA-VC) bearing l-arginine,...
HBDI-like chromophores represent a novel set of biomimetic switches mimicking the fluorophore green fluorescent protein that are currently studied with hope to expand molecular switch/motor toolbox. However, until now members capable absorbing visible light in their neutral (i. e. non-anionic) form have not been reported. In this contribution we report preparation an chromophore based on 3-phenylbenzofulvene scaffold blue and photoisomerizing picosecond timescale. More specifically, show...
In this paper, we propose a rational design of hybrid nanosystem capable locally delivering high amount hydrophobic anticancer drugs (sorafenib or lenvatinib) and heat (hyperthermia) in remote-controlled manner. We combined unique the excellent NIR photothermal conversion gold nanorods (AuNRs) with ability specially designed galactosylated amphiphilic graft copolymer (PHEA-g-BIB-pButMA-g-PEG-GAL) able to recognize hepatic cells overexpressing asialoglycoprotein receptor (ASGPR) on their...
Combined therapy with penicillins and aminoglycosides has been proved beneficial to address many persistent bacterial infections possible synergistic effects. However, the different pharmacokinetic profiles of these two antibiotic classes may not guarantee a concerted spatio-temporal delivery at site action, decreasing efficacy this combination promoting resistance. Herein, we propose multifunctional antibiotic-polymer conjugate, designed colocalize ampicillin gentamicin tackle biofilm...
Abstract A coating technology based on low molecular weight hyaluronic acid (HA) and ferulic (FA) was applied to the of generation poly(propylene imine) dendrimers through a biocompatible hexa(ethylene glycol) spacer. The ensuing HA‐FA‐HEG‐PPID dendrimeric materials showed interesting loading capability (between 7.65% 9.08%) regarding anticancer agent doxorubicin, their interactions with drug appeared hamper release in physiological environment. Thus, stable nanostructured loaded delivery...
Gold nanorods (AuNRs) can combine therapeutic hyperthermia with diagnostic features, representing a smart choice to address personalized cancer treatments. In this regard, crucial quest is the selection of right biocompatible coating agent able stabilize them in physiological environment, further endowing possibility load bioactive molecules and/or targeting moieties. Therefore, AuNRs optical properties be successfully merged advantageous materials features obtain selective photothermal...
A carbon dot-based nanotheranostic platform demonstrated fluorescence imaging and folic acid-targeted doxorubicin therapy with spatio-temporal light-controlled drug release for personalized breast cancer treatment.