A5055184451- Astrophysics and Cosmic Phenomena
- Dark Matter and Cosmic Phenomena
- Characterization and Applications of Magnetic Nanoparticles
- Geomagnetism and Paleomagnetism Studies
- Neutrino Physics Research
- Microfluidic and Bio-sensing Technologies
- Particle physics theoretical and experimental studies
- Radio Astronomy Observations and Technology
- Atmospheric Ozone and Climate
- Photocathodes and Microchannel Plates
- Atmospheric aerosols and clouds
- Radiation Therapy and Dosimetry
- Magnetic properties of thin films
- Atmospheric and Environmental Gas Dynamics
- International Science and Diplomacy
- Impact of Light on Environment and Health
- Iron oxide chemistry and applications
- Particle accelerators and beam dynamics
- Ionosphere and magnetosphere dynamics
- Radio, Podcasts, and Digital Media
- Electrical and Bioimpedance Tomography
- Particle Accelerators and Free-Electron Lasers
- Magnetic Field Sensors Techniques
- Cardiovascular Health and Disease Prevention
- Solar and Space Plasma Dynamics
RWTH Aachen University
2013-2025
Universitätsklinikum Aachen
2015
Johannes Gutenberg University Mainz
1991
Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and particle (MPI), as well fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from polydisperse starting formulation, synthesized using the routinely employed co-precipitation technique. Transmission electron microscopy, dynamic light scattering nanoparticle tracking analyses show that fractions obtained upon...
Magnetic particle imaging (MPI) allows fast of the spatial distribution superparamagnetic iron-oxide based nanoparticles (SPIONs). Recent research suggests that MPI furthermore promises in-vivo access to environmental parameters SPIONs as temperature or viscosity. Various medical applications nanomedicine, stem cell-based therapies magnetic hyperthermia could benefit from multiparameter estimation by MPI. One possible approach get functional is excitation at multiple frequencies. To enable...
Magnetic particle imaging (MPI) is a novel tomographic technique, which visualizes the distribution of magnetic nanoparticle-based tracer material. However, reconstructed MPI images often suffer from an insufficiently compensated image background caused by rapid non-deterministic changes in signal device. In particular, signal-to-background ratio (SBR) reduced for lower concentrations or longer acquisitions. The state-of-the-art procedure to frequently measure during sample measurement....
Nowadays, magnetic particle imaging (MPI) signal detection and excitation happens at the same time. This concept, however, leads to a strong coupling of drive (excitation) field (DF) with receive chain. As induced DF is several orders magnitude higher, special measures have be taken suppress this portion within keep required dynamic range subsequent analog-to-digital conversion in technically feasible range. For frequency space MPI, high-order bandstop-filters been successfully used remove...
In conventional MPI scanners the magnetic nano particle concentration distribution is acquired by moving a field free point (FFP) through FOV [1]. This method allows sampling of signal from small point-like area per time. To gain higher SNR, it was suggested to increase simultaneously volume introducing principal line (FFL) [2]. We propose new generator geometry which capable creating an FFL with simpler coil than existing approaches.
The availability of thorough system simulations for detailed and accurate performance prediction optimization existing future designs a new modality, such as magnetic particle imaging (MPI) are very important. Our framework aims to simulate complete MPI by providing description all (drive receive) coils, permanent magnet configurations, nanoparticle (MNP) distributions, characteristics the signal processing chain. simulation is performed on user defined spatial temporal discrete grid....
Aim of this study is to evaluate whether magnetic particle imaging (MPI) capable measuring velocities occurring in the coronary arteries and compute flow reserve (CFR) a canonical phantom as preliminary study.For basic velocity measurements, circulation was designed containing replaceable glass tubes with three varying inner diameters, matching coronary-vessel diameters. Standardised boluses superparamagnetic-iron-oxide-nanoparticles were injected visualised by MPI. Two image-based...
A big challenge in Magnetic Particle Imaging (MPI) is the separation of actual nanoparticle signal from induced receive coils, as it a superposition drive field (DF) and six orders magnitude smaller particle signal. Usually this problem addressed by applying notch filter to remove well at excitation frequency prior amplifying However, removes strongest well. This for example introduces problems reconstruction which have be addressed, e.g. DC drifts x-space MPI.
The drive field suppression and the particle signal amplification are key components in Magnetic Particle Imaging (MPI) [1]. However, for high signal-to-noise ratio (SNR) noise contribution of receive chain has to be minimized as well. Main sources coil, coils filter stage semiconductor elements pre-amplifier. voltage induced by is about six orders magnitude higher then [2], must suppressed at least 80 dB keep pre-amplifier its linear region. Usually this problem adressed applying a notch...
Magnetic Particle Imaging (MPI) is a promising tool for nanomedicine cancer therapy, allowing to assess drug delivery by quantifying the Enhanced Permeability and Retention (EPR) effect.Usually MPI quantitatively determines spatial distribution of superparamagnetic iron oxide nanoparticles (SPIONs) exploiting their characteristic nonlinear magnetization response changing magnetic field.Current scanners offer high temporal resolution, but are still limited in terms sensitivity capability...