A5017274671- Advanced MRI Techniques and Applications
- Characterization and Applications of Magnetic Nanoparticles
- NMR spectroscopy and applications
- Advanced Neuroimaging Techniques and Applications
- Geomagnetism and Paleomagnetism Studies
- Atomic and Subatomic Physics Research
- Advanced NMR Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Microfluidic and Bio-sensing Technologies
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Cardiovascular Function and Risk Factors
- Magnetic properties of thin films
- Electron Spin Resonance Studies
- Electrical and Bioimpedance Tomography
- Coronary Interventions and Diagnostics
- Minerals Flotation and Separation Techniques
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Elasticity and Material Modeling
- Quantum Electrodynamics and Casimir Effect
- Lanthanide and Transition Metal Complexes
- Cardiac Ischemia and Reperfusion
- Pain Management and Treatment
- Lysosomal Storage Disorders Research
Universitätsklinikum Würzburg
2013-2025
University of Würzburg
2014-2025
European Neuroendocrine Tumor Society
2020
Fraunhofer Institute for Photonic Microsystems
2019
Heidelberg University
2018
German Cancer Research Center
2018
Comprehensive Cancer Center Mainfranken
2017
MRB Research Center for Magnetic Resonance Bavaria
2013
Innsbruck Medical University
2012
Bavarian Research Alliance
2012
Minimally invasive endovascular interventions have become an important tool for the treatment of cardiovascular diseases such as ischemic heart disease, peripheral artery and stroke. X-ray fluoroscopy digital subtraction angiography are used to precisely guide these procedures, but they associated with radiation exposure patients clinical staff. Magnetic Particle Imaging (MPI) is emerging imaging technology using time-varying magnetic fields combined nanoparticle tracers fast highly...
Noninvasive imaging of atherosclerosis remains challenging in clinical applications. Here, we applied noninvasive molecular to detect vascular cell adhesion molecule-1 early and advanced atherosclerotic lesions apolipoprotein E-deficient mice.Ultrasmall superparamagnetic iron oxide particles functionalized with (P03011) or without (P3007) molecule-1-binding peptide were visualized by ultra high-field (17.6 T) magnetic resonance. Injection P03011 resulted a marked signal loss the aortic root...
Purpose:To assess the feasibility of magnetic particle imaging (MPI) to guide stenting in a phantom model. Materials and Methods: MPI is new tomographic method based on background-free field detection tracer agent composed superparamagnetic iron oxide nanoparticles (SPIOs). All experiments were conducted custom-built scanner (field view: 29-mm diameter, 65-mm length; isotropic spatial resolution 1–1.5-mm). Stenosis phantoms (n=3) consisted polyvinyl chloride (PVC) tubes (8-mm inner diameter)...
Abstract Magnetic nanoparticles (MNPs) have been adapted for many applications, e.g., bioassays the detection of biomarkers such as antibodies, by controlled engineering specific surface properties. Specific measurement binding states is high interest but currently limited to highly sensitive techniques ELISA or flow cytometry, which are relatively inflexible, difficult handle, expensive and time-consuming. Here we report a method named COMPASS ( C ritical- O ffset- M agnetic- Pa rticle- S...
Background/Objectives: Fabry disease (FD) is a rare X-linked lysosomal storage disorder characterised by progressive glycolipid accumulation affecting multiple organs, including the peripheral nervous system. The dorsal root ganglia (DRG) play key role in Fabry-related neuropathy, but non-invasive biomarkers of DRG involvement and their association with overall severity remain limited. This study evaluated lumbosacral T2 relaxation time (DRG-T2) FD patients as potential imaging biomarker...
Abstract Background Magnetic particle imaging (MPI) allows for radiation-free visualization of tracers without background signal. With the first human-sized interventional MPI scanner being recently developed, aim present study was to test its performance guiding endovascular procedures in a realistic perfusion model. Methods Three fresh-frozen cadaveric legs were prepared establish continuous circulation superficial femoral artery via introducer sheaths inguinal and infragenicular region....
The dorsal root ganglion (DRG) contains all primary sensory neurons, but its functional role in somatosensory and pain processing remains unclear. Recently, MR imaging techniques have been developed for objective vivo observation of the DRG. In particular, DRG endpoints such as volume T2w signal are emerging biomarkers with initial evidence meaningful correlations biochemical genetic parameters well neuropathic clinically relevant applications. However, future validation use these novel...
Within the frame of lowest-order perturbation theory, van der Waals potential a ground-state atom placed within an arbitrary dispersing and absorbing magnetodielectric multilayer system is given. Examples situated in front plate or between two such plates are studied detail. Special emphasis on competing attractive repulsive force components associated with electric magnetic matter properties, respectively, conditions for formation walls Both numerical analytical results presented.
Monocytes and macrophages are indispensable in the healing process after myocardial infarction (MI); however, spatiotemporal distribution of monocyte infiltration its correlation to prognostic indicators reperfused MI have not been well described.With combined fluorine 19/proton ((1)H) magnetic resonance imaging, we noninvasively visualized recruitment monocytes vivo a rat model MI. Blood were labeled by intravenous injection (19)F-perfluorocarbon emulsion 1 day The patterns correlated...
Magnetic Particle Imaging (MPI) is a fast imaging technique to visualize the distribution of superparamagnetic iron-oxide nanoparticles (SPIONs). For spatial encoding, field free area moved rapidly through view (FOV) generating localized signal. Fast moving samples, e.g., bolus SPIONs traveling large veins in human body carried by blood flow with velocities order ~45 cm/s, cause temporal blurring MPI measurements using common sequences and reconstruction techniques. This hampers evaluation...
Abstract It had been previously shown that an idealized version of the two‐wave‐vector extension NMR pulsed‐field‐gradient spin echo diffusion experiment can be used to determine apparent radius geometries with restricted diffusion. In present work, feasibility was demonstrated in imaging experiment, which axons white matter tissue determined. Moreover, numerical simulations have carried out reliability results. For small times, is systematically underestimated. Larger gradient area, finite...
Magnetic particle imaging (MPI) is a promising new tomographic method to detect the spatial distribution of superparamagnetic iron-oxide nanoparticles (SPIOs). The aim this paper was investigate potential MPI quantify artificial stenoses in vessel phantoms. Custom-made stenosis phantoms (length 40 mm; inner diameter 8 mm) with different degrees (0%, 25%, 50%, 75%, and 100%) were scanned custom-built scanner (in-plane resolution: ~1-1.5 mm field view: 65 29 mm3). Phantoms filled diluted...
This study reports the T(1) and T(2) relaxation rates of rhodamine-labeled anionic magnetic nanoparticles determined at 7, 11.7, 17.6 T both in solution after cellular internalization. Therefore cells were incubated with prepared decreasing concentrations. Additionally, used for extracellular measurements. T. times an inversion-recovery snapshot-flash sequence. obtained from a multispin-echo Inductively coupled plasma-mass spectrometry was to determine iron content all samples, r(1) r(2)...
Background Oncolytic virotherapy of tumors is an up-coming, promising therapeutic modality cancer therapy. Unfortunately, non-invasive techniques to evaluate the inflammatory host response treatment are rare. Here, we 19F magnetic resonance imaging (MRI) which enables visualization processes in pathological conditions by use perfluorocarbon nanoemulsions (PFC) for monitoring oncolytic virotherapy. Methodology/Principal Findings The Vaccinia virus strain GLV-1h68 was used as agent different...
Magnetically labeled cells and tissue iron deposits provide qualitative means to detect monitor cardiovascular cerebrovascular diseases with magnetic resonance imaging. However, quantitatively examine the extent of pathological micromorphological changes, detailed knowledge about microstructural parameters relaxation times is required.The complex geometrical arrangement spherical perturbers considered in an external field. They create a dipole field, whose corresponding spin-echo formation...
We tested the hypothesis that reduced skin innervation in fibromyalgia syndrome is associated with specific CNS changes. This prospective case-control study included 43 women diagnosed and 40 healthy controls. further compared subgroups (n = 21) normal 22) innervation. Brains were analysed for cortical volume, white matter integrity, functional connectivity. Compared to controls, thickness was decreased regions of frontal, temporal parietal cortex group as a whole, bilateral pericalcarine...
A method describing NMR-signal formation in inhomogeneous tissue is presented which covers all diffusion regimes. For this purpose, the frequency distribution inside voxel described. Generalizing results of well-known static dephasing regime, we derive a formalism to describe that valid over whole dynamic range. The expressions obtained are agreement with from Kubos line-shape theory. To examine effects, utilize strong collision approximation, replaces original process by simpler stochastic...
Transverse relaxation by dephasing in an inhomogeneous field is a general mechanism physics, for example, semiconductor muon spectroscopy, or nuclear magnetic resonance. In resonance imaging the transverse provides information on properties of several biological tissues. Since dipole most important part multipole expansion local field, highly theory. However, there have been no analytical solutions which describe field. this work we give complete solution valid over whole dynamic range.
Background 19F magnetic resonance imaging (MRI) was recently introduced as a promising technique for in vivo cell tracking. In the present study we compared MRI with iron-enhanced mice photothrombosis (PT) at 7 Tesla. PT represents model of focal cerebral ischemia exhibiting acute vessel occlusion and delayed neuroinflammation. Methods/Principal Findings Perfluorocarbons (PFC) or superparamagnetic iron oxide particles (SPIO) were injected intravenously different time points after...
We analyze the free induction decay of nuclear spins under influence restricted diffusion in a magnetic dipole field around cylindrical objects. In contrast to previous publications no restrictions or simplifications concerning process are made. By directly solving Bloch-Torrey equation, analytical expressions for magnetization given terms an eigenfunction expansion. The strength-dependent complex nature eigenvalue spectrum significantly influences shape decay. As is lowest order multipole...