A5050126404- Characterization and Applications of Magnetic Nanoparticles
- Geomagnetism and Paleomagnetism Studies
- Microfluidic and Bio-sensing Technologies
- Muon and positron interactions and applications
- X-ray Spectroscopy and Fluorescence Analysis
- Atomic and Molecular Physics
- Magnetic properties of thin films
- Electrical and Bioimpedance Tomography
- Cardiovascular Health and Disease Prevention
- Nuclear Physics and Applications
- Atomic and Subatomic Physics Research
- Physics and Engineering Research Articles
- Advanced MRI Techniques and Applications
- Parallel Computing and Optimization Techniques
- Distributed and Parallel Computing Systems
- Minerals Flotation and Separation Techniques
- Spectroscopy and Quantum Chemical Studies
- Logic, programming, and type systems
- Software Testing and Debugging Techniques
- Magnetic Field Sensors Techniques
- Embedded Systems Design Techniques
- Computability, Logic, AI Algorithms
- Electron and X-Ray Spectroscopy Techniques
- Crystallography and Radiation Phenomena
- Model-Driven Software Engineering Techniques
University of Würzburg
2015-2025
Technical University of Applied Sciences Würzburg-Schweinfurt
2010-2018
Sorbonne Université
2012
Université Paris Cité
2012
Munich University of Applied Sciences
2002-2009
SUNY New Paltz
1993-1999
State University of New York
1997
Justus-Liebig-Universität Gießen
1988-1994
Universitätsklinik für Strahlentherapie
1991
Minimally invasive endovascular interventions have become an important tool for the treatment of cardiovascular diseases such as ischemic heart disease, peripheral artery and stroke. X-ray fluoroscopy digital subtraction angiography are used to precisely guide these procedures, but they associated with radiation exposure patients clinical staff. Magnetic Particle Imaging (MPI) is emerging imaging technology using time-varying magnetic fields combined nanoparticle tracers fast highly...
Most 3-D magnetic particle imaging (MPI) scanners currently use permanent magnets to create the strong gradient field required for high resolution MPI. However, using limits of view (FOV) due large amount energy move free point (FFP) from center scanner. To address this issue, an alternative approach called "Traveling Wave MPI" is here presented. This employs a novel system, dynamic linear array, cover FOV while dynamically creating gradient. The proposed design also enables so-called...
Elucidating how mobile ocean predators utilize the pelagic environment is vital to understanding dynamics of oceanic species and ecosystems. Pop-up archival transmitting (PAT) tags have emerged as an important tool describe animal migrations in environments where direct observation not feasible. Available PAT tag data, however, are for most part limited geographic position, swimming depth environmental temperature, making effective behavioral challenging. However, novel analysis approaches...
While magnetic particle imaging (MPI) constitutes a novel biomedical technique for tracking superparamagnetic nanoparticles in vivo, unlike resonance (MRI), it cannot provide anatomical background information. Until now these two modalities have been performed separate scanners and image co-registration has hampered by the need to reposition sample both systems as similarly possible. This paper presents bimodal MPI-MRI-tomograph that combines single system.MPI MRI images can thus be acquired...
Magnetic particle imaging (MPI) is a non-invasive modality for direct detection of superparamagnetic iron-oxide nanoparticles based on the nonlinear magnetization response magnetic materials to alternating fields. This highly sensitive and rapid method allows both quantitative qualitative analysis measured signal. Since first publication MPI in 2005 several different scanner concepts have been presented 2009 vivo results beating mouse heart were shown. However, since field view (FOV)...
Abstract Magnetic Particle Imaging (MPI) is a promising new tomographic modality for fast as well three-dimensional visualization of magnetic material. For anatomical or structural information an additional imaging such computed tomography (CT) required. In this paper, the first hybrid MPI-CT scanner multimodal providing simultaneous data acquisition presented.
Purpose:To assess the feasibility of magnetic particle imaging (MPI) to guide stenting in a phantom model. Materials and Methods: MPI is new tomographic method based on background-free field detection tracer agent composed superparamagnetic iron oxide nanoparticles (SPIOs). All experiments were conducted custom-built scanner (field view: 29-mm diameter, 65-mm length; isotropic spatial resolution 1–1.5-mm). Stenosis phantoms (n=3) consisted polyvinyl chloride (PVC) tubes (8-mm inner diameter)...
Abstract Magnetic nanoparticles (MNPs) have been adapted for many applications, e.g., bioassays the detection of biomarkers such as antibodies, by controlled engineering specific surface properties. Specific measurement binding states is high interest but currently limited to highly sensitive techniques ELISA or flow cytometry, which are relatively inflexible, difficult handle, expensive and time-consuming. Here we report a method named COMPASS ( C ritical- O ffset- M agnetic- Pa rticle- S...
Abstract Background Magnetic particle imaging (MPI) allows for radiation-free visualization of tracers without background signal. With the first human-sized interventional MPI scanner being recently developed, aim present study was to test its performance guiding endovascular procedures in a realistic perfusion model. Methods Three fresh-frozen cadaveric legs were prepared establish continuous circulation superficial femoral artery via introducer sheaths inguinal and infragenicular region....
Magnetic Particle Imaging (MPI) is a fast imaging technique to visualize the distribution of superparamagnetic iron-oxide nanoparticles (SPIONs). For spatial encoding, field free area moved rapidly through view (FOV) generating localized signal. Fast moving samples, e.g., bolus SPIONs traveling large veins in human body carried by blood flow with velocities order ~45 cm/s, cause temporal blurring MPI measurements using common sequences and reconstruction techniques. This hampers evaluation...
Magnetic particle imaging (MPI) is a promising new tomographic method to detect the spatial distribution of superparamagnetic iron-oxide nanoparticles (SPIOs). The aim this paper was investigate potential MPI quantify artificial stenoses in vessel phantoms. Custom-made stenosis phantoms (length 40 mm; inner diameter 8 mm) with different degrees (0%, 25%, 50%, 75%, and 100%) were scanned custom-built scanner (in-plane resolution: ~1-1.5 mm field view: 65 29 mm3). Phantoms filled diluted...
Magnetic particle imaging (MPI) is a novel tomographic method, which allows determining the distribution of superparamagnetic iron-oxide nanoparticles in three dimensions. So far, various MPI systems have been presented with each one emphasizing different scanner features such as large field view (FOV) or high resolution. For both resolution and FOV, optimization harmonization hardware parameters well tracer material are key prerequisites. The traveling wave (TWMPI) approach uses an array...
Since the first publication in 2005, several different scanner types for magnetic particle imaging (MPI) have been presented. One of these concepts is traveling wave MPI (TWMPI). It uses a dynamic linear gradient array, which generates and moves field free point with strong gradient, necessary scanning sample 3-D. Due to properties TWMPI device, very fast 2-D frame rates higher than 1500 frames/s possible (superspeed mode). Using superspeed mode high speed measurements are conceivable, e.g.,...
Since the introduction of magnetic particle imaging in 2005, several different types scanner were presented. One them is traveling wave (TWMPI) scanner. It uses for a dynamic linear gradient array generation strong and field free point. An unresolved issue TWMPI approach so far non-isotropic spatial resolution. As an alternative this paper, rotating slice scanning mode presented to overcome issue. This rotates scanning-slices around axis projection reconstruction method get 3-D volume with...
Magnetic particle imaging (MPI) is a novel method for the depiction of superparamagnetic materials. Since first publication several MPI scanner were presented, which work at gradient strength ~2-7 T/m. This reasonable in vivo and provides resolution ~1 mm. In this paper, approaches micro-MPI (μMPI) device very small samples are works high magnetic ~85 results theoretical <;100 μm. μMPI can be operated modes, have different advantages. preliminary tests, feasibility has been proven.
Magnetic particle imaging (MPI) is a young modality using the nonlinear magnetization properties of superparamagnetic iron-oxide nanoparticles to acquire them. It highly sensitive and fast method allowing both quantitative qualitative analysis measured signal. Since its first publication in 2005, several different scanner types have been presented. Most them work with permanent magnets therefore small field view. In 2014, an alternative concept, traveling wave MPI (TWMPI), was presented,...
Magnetic particles have become a core ingredient for many applications in chemistry, biology, and medical diagnostics, e.g., as basis bioanalytical methods or tracer material imaging. This paper presents new method called rotational drift spectroscopy (RDS) which uses rotating magnetic fields measuring the properties of nanoparticles (MNPs) liquid suspensions. The RDS signal is based on nonlinear behavior MNPs fields, highly dependent well their interaction with environment. dependency...
Magnetic particle imaging (MPI) is a promising tomographic technique for the fast and sensitive visualization of superparamagnetic iron-oxide nanoparticles (SPIONs). Different types MPI scanners have been presented in past providing 2-D as well 3-D data with different sizes field view (FOV). With increasing FOVs, often spatial resolution decreases. Traveling wave (TWMPI) provide possibility to visualize entire available FOV within scanner at once good high temporal resolution. However, more...
The success of tracer-based tomographic methods, such as Magnetic Particle Imaging (MPI), depends on two factors primarily: scanner hardware and tracer performance. Within the last years, several improvements have been presented improving temporal spatial resolution MPI systems. However, there was still a lack efficient commercially available tracers for MPI. Here we report synomag® particles new tailored MPI, which shows almost four-times higher signal in Traveling Wave than established...