A5071719121- Venous Thromboembolism Diagnosis and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Intramuscular injections and effects
- Platelet Disorders and Treatments
- Artificial Intelligence in Healthcare
- Multiple Myeloma Research and Treatments
- Machine Learning in Healthcare
- Protein Degradation and Inhibitors
- CAR-T cell therapy research
- Liver Diseases and Immunity
- Blood Coagulation and Thrombosis Mechanisms
- Atrial Fibrillation Management and Outcomes
- Meta-analysis and systematic reviews
- Liver Disease Diagnosis and Treatment
- Mast cells and histamine
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Virus-based gene therapy research
- Biomedical Text Mining and Ontologies
- Antiplatelet Therapy and Cardiovascular Diseases
- Drug-Induced Hepatotoxicity and Protection
- Proteoglycans and glycosaminoglycans research
- Clinical Laboratory Practices and Quality Control
- Hematopoietic Stem Cell Transplantation
- Artificial Intelligence in Healthcare and Education
- Asthma and respiratory diseases
University of Bern
2021-2025
University Hospital of Bern
2021-2025
RWTH Aachen University
2021
Maastricht University
2021
Chimeric antigen receptor T-cell therapy (CAR therapy) is associated with potentially life-threatening toxicities, most commonly cytokine release syndrome (CRS) and immune-effector-cell-associated neurotoxicity (ICANS). These frequent adverse events are managed the IL-6 antagonist tocilizumab and/or corticosteroids. The prophylactic early use of corticosteroids for CRS ICANS have previously been reported, but eventual negative impacts on CAR efficacy feared.Retrospective comparative analysis...
Precision medicine, utilizing genomic and phenotypic data, aims to tailor treatments for individual patients. However, successful implementation into clinical practice is challenging. Machine learning (ML) algorithms have demonstrated incredible capabilities in handling probabilities, managing diverse datasets, are increasingly applied precision medicine research. The key ML applications include classification diagnosis, patient stratification, prognosis, treatment monitoring. offers...
Importance Heparin-induced thrombocytopenia (HIT) is a life-threatening condition that requires urgent diagnostic clarification. However, knowledge of the utility recommended tests limited in clinical practice. Objective To evaluate current practice for managing suspicion HIT. Design, Setting, and Participants This prospective study was conducted from January 2018 to May 2021 among consecutive patients with suspected HIT 11 centers Switzerland, Germany, United States. Detailed data...
Expression of CD2, CD25 and/or CD30 in extracutaneous mast cells (MC) is a minor diagnostic criterion for systemic mastocytosis (SM) the classification World Health Organization and International Consensus Classification. So far, it remains unknown whether expression these antigens on MC prognostic significance SM. We performed retrospective multi-center study patients with SM using data set registry European Competence Network Mastocytosis, including 5034 various disorders. The percentage...
Background & aims Chronic liver diseases pose a serious public health issue. Identifying patients at risk for advanced fibrosis is crucial early intervention. The Fibrosis-4 score (FIB-4), simple non-invasive test, classifies into three groups fibrosis. This study aimed to estimate the prevalence of hepatic Swiss tertiary care hospital by calculating FIB-4 in routine blood analysis. Methods A retrospective was conducted using data from 36,360 who visited outpatient clinics eight main...
Thrombophilia, a blood coagulation disorder, poses risks of venous thromboembolism (VTE). Coagulation assays may not be sufficient to assess VTE risk and global such as Rotational Thromboelastometry (ROTEM) add valuable information. We investigated ROTEM's capacity detect hypercoagulability in patients undergoing thrombophilia screening, its potential impact on patient outcomes, limitations. Comprehensive clinical, laboratory, genetic tests, ROTEM (EXTEM INTEM) were conducted for 356...
(1) Background: The combination of venetoclax and hypomethylating agents (HMAs) is a standard first-line regimen for acute myeloid leukemia (AML) patients unfit intensive chemotherapy. Since venetoclax-HMAs are usually administered until progression delayed hematologic recovery one the limiting toxicities, cyclic administration including 7-14-day breaks recommended. However, whether longer schedules lead to higher response rates how pharmacokinetics correlate with toxicity efficacy remains...
New analytical techniques can assess hundreds of proteins simultaneously with high sensitivity, facilitating the observation their complex interplay and role in disease mechanisms. We hypothesized that proteomic profiling targeting involved thrombus formation, inflammation, immune response would identify potentially new biomarkers for heparin-induced thrombocytopenia (HIT). Four existing panels Olink proximity extension assay covering 356 were applied to randomly selected patients suspected...
Abstract Purpose To evaluate the efficacy of a subthreshold micropulse laser (SML) in patients with central serous chorioretinopathy (CSCR). Methods Retrospective clinical study conducted at Departments Ophthalmology university and municipal hospital Zurich, Switzerland. We enrolled acute chronic CSCR persistent subretinal fluid (SRF) treated SML. Two treatment protocols (fluorescein/indocyanine green angiography or optical coherence tomography guided) were evaluated for after 3 6 months....
Chimeric antigen receptor (CAR)-T cell therapy is effective in patients with relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL) response rates of 63-84% and complete observed 43-54%. Common germline variants the target CD19 may elicit different responses to CAR-T therapy. The gene single nucleotide polymorphism rs2904880 encoding leucine valine at amino acid position 174 was prevalent 51% studied DLBCL patients. In a retrospective comparative analysis clinical outcome, there...
Chimeric antigen receptor T (CAR T)-cell therapy has become a standard treatment option for patients with relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL). Mutations in the PPM1D gene, frequent driver alteration clonal hematopoiesis (CH), lead to gain of function PPM1D/Wip1 phosphatase, impairing p53-dependent G1 checkpoint and promoting cell proliferation. The presence mutations been correlated reduced response chemotherapy patients. In this study, we analyzed impact...
Gallo et al. assessed the impact of implementing a clinical decision support tool in multi‐hospital setting. This is one three important points to unlock capabilities next‐generation diagnostic instruments: (a) integrating information from various sources, (b) ensuring accurate development and validation well‐designed studies (c) seamlessly them into practice. Commentary on: Clinical reduce unnecessary testing for heparin‐induced thrombocytopenia. Br J Haematol 2023;202:1011–1017.
Introduction: The growing body of evidence around sexual and gender dimorphism in medicine, particularly oncology, has highlighted differences treatment response, outcomes, side effects between males females. Differences drug metabolism, distribution, elimination, influenced by factors like composition enzyme expression, contribute to these variations. Methods: We retrospectively analyzed data 112 multiple myeloma (MM) patients treated with first-line high-dose chemotherapy (HDCT) treosulfan...