A5010968818- Platelet Disorders and Treatments
- Blood transfusion and management
- Blood groups and transfusion
- Blood disorders and treatments
- Immune Response and Inflammation
- Blood donation and transfusion practices
- Erythrocyte Function and Pathophysiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood properties and coagulation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- COVID-19 Clinical Research Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Hemoglobinopathies and Related Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Sepsis Diagnosis and Treatment
- Complement system in diseases
- Immunotherapy and Immune Responses
- HIV Research and Treatment
- Venous Thromboembolism Diagnosis and Management
- Extracellular vesicles in disease
- SARS-CoV-2 and COVID-19 Research
- HIV-related health complications and treatments
- Blood Coagulation and Thrombosis Mechanisms
- Reproductive tract infections research
Université Jean Monnet
2008-2025
Inserm
2009-2025
Mines Saint-Étienne
2022-2025
Biologie, ingénierie et imagerie pour l'Ophtalmologie
2006-2024
Georges Friedel Laboratory
2024
Université Claude Bernard Lyon 1
2014-2023
Établissement Français du Sang
2010-2023
Université de Montpellier
2023
Centre National de la Recherche Scientifique
2023
Centre Hospitalier Universitaire de Montpellier
2023
Summary Blood platelets link the processes of haemostasis and inflammation. This study examined immunomodulatory factors released by after Toll‐Like Receptor 4 (TLR4) engagement on their surfaces. Monoclonal anti‐human FcγRII Ab (IV.3)‐treated human were cultured with TLR4 ligands in presence or absence blocking monoclonal antibody to TLR4. The release sCD62p, epidermal growth factor (EGF), transforming β (TGFβ), interleukin (IL)‐8, platelet activating (PAF4), platelet‐derived factor, α,...
BACKGROUND Whereas platelet transfusion is a common medical procedure, inflammation still occurs in fraction of transfused individuals despite the absence any apparent infectious agents. Platelets can shed membrane vesicles, called extracellular vesicles (EVs), some which contain mitochondria (mito+EV). With its content damage‐associated molecular pattern (DAMP), mitochondrion stimulate innate immune system. Mitochondrial DNA (mtDNA) recognized DAMP detected milieu numerous inflammatory...
ABSTRACT The use of microbicides is a promising approach for the prevention HIV-1 transmission. Unfortunately, various candidates failed in clinical trials. In some cases, candidate microbicide even resulted enhanced virus Therefore, there an urgent need to develop more predictive preclinical strategies anticipate vivo efficiency/toxicity rate, including vitro assays that evaluate effects on epithelial integrity and inflammation. present study aims identify potential safety issues concerning...
Background Leukoreduction of labile blood components dramatically decreases the frequency minor, intermediate, and severe adverse events ( AE s), referred to as acute transfusion reactions ATR especially after platelet PC s). The pathophysiology s may result from accumulation soluble, secreted, (PLT) factors with proinflammatory functions stored in s. Thus, several cosynergizing associated PLT contribute clinically reported inflammatory symptoms. Study Design Methods We screened for 65...
Introduction People living with HIV (PLWH) now benefit from combined antiviral treatments that durably control viral replication. These antiretroviral decrease mortality and improve quality of life in PLWH, but do not completely the excessive non-specific activation immune system PLWH. This chronic is a key element immunopathology contributes to pathophysiology inflammatory comorbid conditions, such as cardiovascular disorders, cancer autoimmune diseases. Circulating non-exosomal...
Immunological disturbances (anti-type I IFN auto-antibody production, cytokine storm, lymphopenia, T-cell hyperactivation and exhaustion) are responsible for disease exacerbation during severe COVID-19 infections. In this study, we set up a prospective, randomised clinical trial (ClinicalTrials.gov ID: NCT04751643) performed therapeutic plasma exchange (TPE) in patients order to decrease excess cytokines auto-antibodies assess whether adding TPE the standard treatment (ST, including...
Background: Platelets are crucial mediators at the crossroads of hemostasis, immunity, and inflammation, adapting their responses to diverse stimuli. Despite recognized role, precise pathways markers associated with platelet activation remain poorly understood. This study aimed unravel these mechanisms by evaluating various agonists, employing biomathematical models map patterns identify key biomarkers. Methods: Using samples from ten healthy donors, platelets were exposed seven stimulation...
Introduction The treatment of chronic viral infections can often bring replication under control. However, immune activation persists and lead to the development comorbid conditions, such as cardiovascular disease cancer. This is particularly true for people living with HIV (PLWH), who have significantly more extracellular vesicles from membrane budding, also called plasma microparticles (MPs), than healthy individuals (HDs), a much immunomodulatory phenotype. We hypothesized that number...