A5080539828- Drug Solubulity and Delivery Systems
- Drug Transport and Resistance Mechanisms
- Advanced Drug Delivery Systems
- Analytical Chemistry and Chromatography
- HIV/AIDS drug development and treatment
- Crystallization and Solubility Studies
- Analytical Methods in Pharmaceuticals
- Gastrointestinal motility and disorders
- Pharmacological Effects and Toxicity Studies
- Diet and metabolism studies
- Pharmaceutical studies and practices
- Protein purification and stability
- Antibiotics Pharmacokinetics and Efficacy
- HIV Research and Treatment
- Gastroesophageal reflux and treatments
- Pharmacogenetics and Drug Metabolism
- Mesoporous Materials and Catalysis
- Reproductive tract infections research
- Bariatric Surgery and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Biochemical and Molecular Research
- Metabolism and Genetic Disorders
- Computational Drug Discovery Methods
KU Leuven
2016-2025
University Hospital of Zurich
2013
Weatherford College
2013
Pharmac
2001-2011
Flemish Institute for Technological Research
2008
Université de Montpellier
2008
Research Triangle Park Foundation
1993-2000
University of Kansas
1995
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread around the globe after its emergence in Wuhan December 2019. With no specific therapeutic and prophylactic options available, virus has infected millions of people which more than half a million succumbed to viral disease, COVID-19. The urgent need for an effective treatment together with lack small animal infection models led clinical trials using repurposed drugs without preclinical evidence their vivo efficacy. We...
Colonic microbial metabolism substantially contributes to uremic solute production. p -Cresyl sulfate and indoxyl are the main representatives of solutes origin also, protein-bound solutes, exhibiting high protein-binding affinity dependence on tubular secretion. Phenylacetylglutamine is another metabolite with secretion but low affinity. The relevance such unknown. Therefore, we prospectively followed 488 patients CKD stages 1–5 a measurement serum phenylacetylglutamine by liquid...
Favipiravir and Molnupiravir, orally available antivirals, have been reported to exert antiviral activity against SARS-CoV-2. First efficacy data recently in COVID-19 patients.We here report on the combined effect of both drugs a SARS-CoV-2 Syrian hamster infection model. The infected hamsters were treated twice daily with vehicle (the control group) or suboptimal dose each compound combination compounds.When animals doses Molnupiravir at time infection, marked potency endpoint is observed....
Abstract There is an urgent need for potent and selective antivirals against SARS-CoV-2. Pfizer developed PF-07321332 (PF-332), a inhibitor of the viral main protease (Mpro, 3CLpro) that can be dosed orally in clinical development. We here report PF-332 exerts equipotent vitro activity four SARS-CoV-2 variants concerns (VoC) it completely arrest replication alpha variant primary human airway epithelial cells grown at air-liquid interface. Treatment Syrian Golden hamsters with (250 mg/kg,...
The ordered mesoporous silica material SBA-15 was loaded with the model drugs itraconazole and ibuprofen using three different procedures: (i) adsorption from solution, (ii) incipient wetness impregnation, (iii) heating of a mixture drug powder. location molecules in particles molecular interactions were investigated nitrogen adsorption, TGA, DSC, DRS UV−vis, XPS. vitro release hydrophobic evaluated an aqueous environment simulating gastric fluid. effectiveness loading method found to be...