A5052211814- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Antifungal resistance and susceptibility
- Cell Image Analysis Techniques
- Olfactory and Sensory Function Studies
- Antibiotic Use and Resistance
- Long-Term Effects of COVID-19
- Research on Leishmaniasis Studies
- Plant Pathogens and Fungal Diseases
- PARP inhibition in cancer therapy
- bioluminescence and chemiluminescence research
- Nail Diseases and Treatments
- Antibiotic Resistance in Bacteria
- Biocrusts and Microbial Ecology
- Pneumocystis jirovecii pneumonia detection and treatment
- Mosquito-borne diseases and control
- Vagus Nerve Stimulation Research
- Antibiotics Pharmacokinetics and Efficacy
KU Leuven
2021-2024
Rega Institute for Medical Research
2021-2024
Radboud University Medical Center
2019-2021
Radboud University Nijmegen
2019-2021
Favipiravir and Molnupiravir, orally available antivirals, have been reported to exert antiviral activity against SARS-CoV-2. First efficacy data recently in COVID-19 patients.We here report on the combined effect of both drugs a SARS-CoV-2 Syrian hamster infection model. The infected hamsters were treated twice daily with vehicle (the control group) or suboptimal dose each compound combination compounds.When animals doses Molnupiravir at time infection, marked potency endpoint is observed....
There are, besides remdesivir, no approved antivirals for the treatment of SARS-CoV-2 infections. To aid in search against this virus, we explored use human tracheal airway epithelial cells (HtAEC) and small (HsAEC) grown at air-liquid interface (ALI). These cultures were infected apical side with one two different isolates. Each virus was shown to replicate high titers extended periods time (at least 8 days) and, particular an isolate D614G spike (S) protein did so more efficiently 35 °C...
Can SARS-CoV-2 hitchhike on the olfactory projection and take a direct short route from nose into brain? We reasoned that neurotropic or neuroinvasive capacity of virus, if it exists, should be most easily detectable in individuals who died an acute phase infection. Here, we applied postmortem bedside surgical procedure for rapid procurement tissue, blood, cerebrospinal fluid samples deceased COVID-19 patients infected with Delta, Omicron BA.1, BA.2 variants. Confocal imaging sections...
Despite the advances in contemporary medicine and availability of numerous innovative therapies, effective treatment prevention SARS-CoV-2 infections pose a challenge. In search for new anti-SARS-CoV-2 drug candidates, natural products are frequently explored. Here, fifteen cyanopeptolins (CPs) were isolated from Baltic cyanobacterium Nostoc edaphicum tested against SARS-CoV-2. Of these depsipeptides, Arg-containing structural variants showed strongest inhibition Delta infection...
The emergence of new SARS-CoV-2 variants and the replacement preceding isolates have been observed through B.1.1.7, B.1.351, B.1.617.2, B.1.1.529 lineages (corresponding to alpha, beta, delta, omicron concern (VoC), respectively). However, there is still a lack biological evidence which extent those VoC differ from ancestral lineages. By exploiting human airway epithelial cell (HAEC) cultures, closely resemble architecture physiology, we report distinctive tropism in different respiratory...
The use of fixed dose-combinations antivirals with different mechanisms action has proven key in the successful treatment infections HIV and HCV. For SARS-CoV-2 possible future epi-/pandemic coronaviruses, it will be important to explore efficacy combinations drugs, particular avoid resistance development, such as patients immunodeficiencies. This work explores effect a combination 3 broad-spectrum antiviral nucleosides on replication coronaviruses. To that end, we made primary human airway...
The use of fixed dose-combinations antivirals with different mechanisms action has proven a key in the successful treatment infections HIV and HCV. For SARS-CoV-2 possible future epi-/pandemic coronaviruses, it will be important to explore efficacy combinations drugs, particular avoid resistance development, such as patients immunodeficiencies. As first effort, we studied antiviral potency antivirals. To that end, made primary human airway epithelial cell (HAEC) cultures grown at air-liquid...
ABSTRACT There are, besides remdesivir, no approved antivirals for the treatment of SARS-CoV-2 infections. To aid in search against this virus, we explored use human tracheal airway epithelial cells (HtAEC) and small (HsAEC) grown at air/liquid interface (ALI). These cultures were infected apical side with one two different isolates. Each virus was shown to replicate high titers extended periods time (at least 8 days) and, particular an isolate D614G spike (S) protein did so more efficiently...