A5021940496- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Ear Surgery and Otitis Media
- Vestibular and auditory disorders
- Noise Effects and Management
- Facial Nerve Paralysis Treatment and Research
- Meningioma and schwannoma management
- Head and Neck Anomalies
- Ear and Head Tumors
- Congenital Ear and Nasal Anomalies
- Cell Adhesion Molecules Research
- Hearing Impairment and Communication
- Neurofibromatosis and Schwannoma Cases
- Tracheal and airway disorders
- Sinusitis and nasal conditions
- Multisensory perception and integration
- Cerebral Venous Sinus Thrombosis
- Head and Neck Surgical Oncology
- Reconstructive Facial Surgery Techniques
- Ophthalmology and Eye Disorders
- Transcranial Magnetic Stimulation Studies
- Health Literacy and Information Accessibility
- Congenital heart defects research
- Platelet Disorders and Treatments
- Speech and Audio Processing
Vrije Universiteit Brussel
2021-2025
Antwerp University Hospital
2012-2024
University of Antwerp
2007-2024
Universitair Ziekenhuis Brussel
2022-2023
University Medical Center Utrecht
2009-2020
Utrecht University
2012-2020
ENT and Allergy
2020
Radboud University Nijmegen
2004-2015
Radboud University Medical Center
2005-2015
Leiden University Medical Center
2015
A multicenter study was set up to elucidate the environmental and medical risk factors contributing age-related hearing impairment (ARHI). Nine subsamples, collected by nine audiological centers across Europe, added a total of 4,083 subjects between 53 67 years. Audiometric data (pure-tone average [PTA]) were participants filled out questionnaire on history. People with history disease that could affect excluded. PTAs adjusted for age sex tested association exposure factors. Noise associated...
Can SARS-CoV-2 hitchhike on the olfactory projection and take a direct short route from nose into brain? We reasoned that neurotropic or neuroinvasive capacity of virus, if it exists, should be most easily detectable in individuals who died an acute phase infection. Here, we applied postmortem bedside surgical procedure for rapid procurement tissue, blood, cerebrospinal fluid samples deceased COVID-19 patients infected with Delta, Omicron BA.1, BA.2 variants. Confocal imaging sections...
Age-related hearing impairment (ARHI) is the most prevalent sensory in elderly. ARHI a complex disease caused by an interaction between environmental and genetic factors. The contribution of various factors has been relatively extensively studied. In contrast, investigations to identify risk have only recently initiated. this paper we describe results association study performed on 2418 samples derived from nine centers seven European countries. 70 candidate genes, total 768 tag single...
Age-related hearing impairment (ARHI) is the most common sensory among elderly. It a complex disorder influenced by genetic as well environmental factors. SNPs in candidate susceptibility gene, KCNQ4, were examined two independent Caucasian populations. Two quantitative trait locus (QTL) values investigated: Zhigh and Zlow, measure of high respectively low frequency loss. In first population, statistical analysis 23 genotyped spread across KCNQ4 resulted significant p-values for Zhigh-SNP9...
In Brief Objectives: The goals of the present study were twofold: in first part, prevalence and profile hearing disability healthy, middle-aged persons determined by speech, spatial, qualities scale (SSQ). second part this study, number SSQ items was reduced to five make questionnaire available for routine usage clinical settings screening purposes. Methods: responses derived from 103 normal-hearing 18- 25-year-old compared with 24 clinically (all thresholds between 125 8000 Hz ≤25 dB HL)...
Type 2 collagen disorders encompass a diverse group of skeletal dysplasias that are commonly associated with orthopedic, ocular, and hearing problems. However, the frequency many clinical features has never been determined. We retrospectively investigated clinical, radiological, genotypic data in 93 patients molecularly confirmed SEDC or related disorder. The majority (80/93) had short stature, radiological (n = 64), others having SEMD 5), Kniest dysplasia 7), spondyloperipheral 2),...
Objective: To compare the cognitive evolution of older adults with severe or profound hearing impairment after cochlear implantation that a matched group who do not receive implant (CI). Design: In this prospective, longitudinal, controlled, and multicenter study, 24 CI users were included in intervention without control group. The terms gender, age, formal education, functioning, residual hearing. Assessments made at baseline 14 months later. Primary outcome measurements change total score...
Image-guided and robot-assisted surgeries have found their applications in skullbase surgery. Technological improvements terms of accuracy also opened new opportunities for robotically-assisted cochlear implantation surgery (RACIS). The HEARO® robotic system is an otological next-generation surgical robot to assist the surgeon. It first provides software-defined spatial boundaries orientation reference information anatomical structures during neurosurgical procedures. Second, it executes a...
Purpose This study aims to evaluate the effectiveness of ChatGPT-4, an artificial intelligence (AI) chatbot, in providing accurate and comprehensible information patients regarding otosclerosis surgery. Methods On October 20, 2023, 15 hypothetical questions were posed ChatGPT-4 simulate physician-patient interactions about Responses evaluated by three independent ENT specialists using DISCERN scoring system. The readability was multiple indices: Flesch Reading Ease (FRE), Flesch-Kincaid...
The aim of this study was to describe the prevalence specific audiogram configurations in a healthy, otologically screened population between 55 and 65 years old. audiograms 1147 subjects (549 males 598 females old) were collected through registries classified according configuration hearing loss. Gender noise/solvent-exposure effects on different shapes determined statistically. In our 'Flat' most dominantly represented (37%) followed by 'High frequency Gently sloping' (35%) Steeply (27%)....
<b>Background:</b> Age-related hearing impairment (ARHI) is the most common sensory in older people, affecting 50% of those aged 80 years. The proportion people increasing general population, and as a consequence, number affected with ARHI growing. complex disorder, both environmental genetic factors contributing to disease. first studies elucidate these were recently performed, resulting identification two susceptibility genes for ARHI, <i>NAT2</i> <i>KCNQ4</i>. <b>Methods:</b> In present...
BACKGROUND: Vestibular schwannomas (VSs) are the most common cerebellopontine angle tumors, accounting for 75% of all lesions in this location. OBJECTIVE: To evaluate results after removal VS through enlarged translabyrinthine approach, which is a widening classic approach that gives larger access and provides more room to facilitate tumor minimize surgery-related morbidities. METHODS: This was retrospective study 1865 patients who underwent excision between 1987 2009. Mean age 50.39 years....
<h3>Importance</h3> The cost of bilateral cochlear implantation (BCI) is usually not reimbursed by insurance companies because a lack well-designed studies reporting the benefits second implant. <h3>Objective</h3> To determine simultaneous BCI compared with unilateral (UCI) in adults postlingual deafness. <h3>Design, Setting, and Participants</h3> A multicenter randomized clinical trial was performed. study took place 5 Dutch tertiary referral centers: University Medical Centers Utrecht,...
Abstract Although the spiral anatomy of human cochlea seems evident, measuring highly inter-variable true dimensions is still challenging. Today, only a few three-dimensional reconstruction models inner ear are available. Previously, equations were applied to two-dimensional computed tomography (CT) images predict electrode insertion depth prior cochlear implantation. The study aimed primarily compare clinical applicability two analytical using recently introduced planning software array 46...
Objectives: The objective of this study was to assess the differences in recurrence rates vestibular schwannoma (VS) after total tumor removal through enlarged translabyrinthine (ETL), retrosigmoid (RS), and middle cranial fossa (MCF) approaches. Our results were compared with previously published data, literature reviews done identify possible causes for VS. Methods: We performed a retrospective analysis 2,400 cases VS that underwent at Gruppo Otologico, Piacenza, Italy, from 1983 until...
Mal de Debarquement Syndrome (MdDS) is a neurological condition typically characterized by sensation of motion, that persists longer than month following exposure to passive motion (e.g., cruise, flight, etc.). The most common form MdDS triggered (MT). However, recently it has been acknowledged some patients develop typical symptoms without an apparent trigger. These cases are identified here as spontaneous or other onset (SO) MdDS. This study aimed address similarities and differences...
Tinnitus is a complex symptom requiring thorough multidisciplinary assessment to construct an individual's tinnitus profile. The Antwerp University Hospital hosts tertiary clinic providing intensive, care in the form of combinational psychological treatment with either Retraining Therapy (TRT)/Cognitive Behavioral (CBT) or TRT/eye movement desensitization and reprocessing therapy (EMDR), high-definition transcranial direct current stimulation (HD-tDCS), physical (in cases somatic influence...
Chronic otitis media with effusion (OME) has been associated a shift in microbiome composition and microbial interaction the upper respiratory tract (URT). While most studies have focused on potential pathogens, this study aimed to find bacteria that could be protective against OME through case-control characterization of isolates from healthy subjects. The URT ear profiles 70 chronic patients 53 controls were compared by 16S rRNA amplicon sequencing. Haemophilus influenzae was frequent...
Cochlear implants (CI) are the most successful bioprosthesis in medicine probably due to tonotopic anatomy of auditory pathway and course brain plasticity. Correct placement CI arrays, respecting inner ear therefore important. The ideal trajectory insert a cochlear implant array is defined by an entrance through round window membrane continues as long possible parallel basal turn cochlea. Image-guided surgery can directly drill with robotic arm mastoid execute exact drilling this...