A5101464459- Long-Term Effects of COVID-19
- Olfactory and Sensory Function Studies
- Growth Hormone and Insulin-like Growth Factors
- Cancer-related molecular mechanisms research
- Vagus Nerve Stimulation Research
- Respiratory viral infections research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Antifungal resistance and susceptibility
- SARS-CoV-2 and COVID-19 Research
- Diet and metabolism studies
- Circular RNAs in diseases
- Glycosylation and Glycoproteins Research
- Nutrition and Health in Aging
- Pancreatic function and diabetes
- Glycogen Storage Diseases and Myoclonus
- Fungal Infections and Studies
- Extracellular vesicles in disease
- Viral Infections and Immunology Research
- MicroRNA in disease regulation
James Madison University
2025
Max Planck Research Unit for Neurogenetics
2021-2023
Tamworth Hospital
2021
Seoul National University Hospital
2018
Highlights•A postmortem bedside surgical procedure was developed for COVID-19 and control patients•Ciliated cells are the main target cell type SARS-CoV-2 in respiratory mucosa•Sustentacular (non-neuronal) olfactory mucosa•No evidence infection of sensory neurons or bulb parenchymaSummaryAnosmia, loss smell, is a common often sole symptom COVID-19. The onset sequence pathobiological events leading to dysfunction remains obscure. Here, we have harvest endoscopically samples mucosae whole...
Can SARS-CoV-2 hitchhike on the olfactory projection and take a direct short route from nose into brain? We reasoned that neurotropic or neuroinvasive capacity of virus, if it exists, should be most easily detectable in individuals who died an acute phase infection. Here, we applied postmortem bedside surgical procedure for rapid procurement tissue, blood, cerebrospinal fluid samples deceased COVID-19 patients infected with Delta, Omicron BA.1, BA.2 variants. Confocal imaging sections...
SARS-CoV-2 is a single-stranded positive-sense RNA virus. Several negative-sense species, both full-length genomic and subgenomic, are produced transiently during viral replication. Methodologies for rigorously characterising cell tropism visualising ongoing replication at single-cell resolution in histological sections needed to assess the virological pathological phenotypes of future variants. We aimed provide robust methodology examining human lung, major target organ this virus.A...
Objectives . Because thyroid hormone is an important determinant of body weight and basal metabolic rate, we investigated the changes in rate composition sequentially after treatment for Graves’ disease. Methods A prospective cohort study was performed with six women newly diagnosed During a 52-week methimazole, composition, resting respiratory expenditure (REE), handgrip strength were measured consecutively. Results After methimazole treatment, initially increased (0–8 weeks), subsequently...
Abstract S3.3 Innate immune responses to pathogenic fungi, September 21, 2022, 4:45 PM - 6:15 Objectives Up 20% and 15% of critically ill influenza coronavirus disease 2019 (COVID-19) patients are affected by influenza- COVID-19-associated pulmonary aspergillosis (IAPA CAPA) respectively. These viral-fungal coinfections difficult diagnose associated with increased mortality. Mechanistic insights into the development IAPA CAPA a prerequisite for new biomarkers novel immunomodulatory...