A5009283491- Lymphoma Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- HER2/EGFR in Cancer Research
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Viral-associated cancers and disorders
- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Radiopharmaceutical Chemistry and Applications
- Cutaneous Melanoma Detection and Management
- Cell Image Analysis Techniques
- Cancer Immunotherapy and Biomarkers
- CNS Lymphoma Diagnosis and Treatment
- Greenhouse Technology and Climate Control
- Medical Imaging Techniques and Applications
- CAR-T cell therapy research
- Advanced Fluorescence Microscopy Techniques
- Vector-borne infectious diseases
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Sarcoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- COVID-19 Impact on Reproduction
- Cancer Cells and Metastasis
KU Leuven
2015-2025
Universitair Ziekenhuis Leuven
2020-2024
Centre Hospitalier Interrégional Edith Cavell
2007-2015
Hôpital de Jolimont
2007
Hartcentrum Hasselt
2004
Directorate-General for Interpretation
1987-1990
Centre hospitalier Etterbeek-Ixelles
1989
Highlights•A postmortem bedside surgical procedure was developed for COVID-19 and control patients•Ciliated cells are the main target cell type SARS-CoV-2 in respiratory mucosa•Sustentacular (non-neuronal) olfactory mucosa•No evidence infection of sensory neurons or bulb parenchymaSummaryAnosmia, loss smell, is a common often sole symptom COVID-19. The onset sequence pathobiological events leading to dysfunction remains obscure. Here, we have harvest endoscopically samples mucosae whole...
Context.— The number of neonates with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is increasing, and in a few there are reports intrauterine infection. Objective.— To characterize the placental pathology findings preselected cohort infected by transplacental transmission arising from maternal SARS-CoV-2, to identify risk factors for fetal Design.— Case-based retrospective analysis multinational group 19 perinatal specialists cohorts infants delivered mothers...
In melanoma, the lymphocytic infiltrate is a prognostic parameter classified morphologically into ‘brisk’, ‘non-brisk’ and ‘absent’ entailing functional association that has never been proved. Recently, it shown populations can be very heterogeneous, anti-PD-1 immunotherapy supports activated T cells. Here, we characterize immune landscape in primary melanoma by high-dimensional single-cell multiplex analysis tissue sections (MILAN technique) followed image analysis, RT-PCR shotgun...
Context.— SARS-CoV-2 can undergo maternal–fetal transmission, heightening interest in the placental pathology findings from this infection. Transplacental transmission is typically accompanied by chronic histiocytic intervillositis together with necrosis and positivity of syncytiotrophoblast for SARS-CoV-2. Hofbauer cells are macrophages that have been involved viral diseases, including HIV Zika virus, but their involvement unknown. Objective.— To determine whether extend beyond to enter...
Access at https://isn-slidearchive.org/?col=ISN&fol=Archive&file=BPA-25-02-CIR-059.svs. A 23-year-old woman presented to the emergency department with headaches and imbalance. Computer tomography imaging was obtained first showed presence of a hemorrhagic lesion in left cerebellum (not shown). Subsequent magnetic resonance heterogeneously enhancing mass measuring 3.4 × 2.1 2.4 cm peripheral blood products (Figure 1). There associated vasogenic edema effect on posterior lateral brainstem...
Abstract Defective cell migration causes delayed wound healing (WH) and chronic skin lesions. Autologous micrograft (AMG) therapies have recently emerged as a new effective affordable treatment able to improve capacity. However, the precise molecular mechanism through which AMG exhibits its beneficial effects remains unrevealed. Herein we show that improves re-epithelialization by accelerating of fibroblasts keratinocytes. More specifically, AMG-treated wounds showed improvement...
Aims As important prognostic and predictive information can be obtained from the composition, functionality spatial arrangement of different immune cell subtypes, this study aims at characterizing infiltrate in breast tumours. Methods results Tumour‐infiltrating lymphocytes (TILs) 62 patients with luminal B‐like cancer were characterised by immunohistochemical staining standard markers, subsequently classified quantified use QuPath software. In delineated tumour regions, proportion density...
Abstract The low abundance of Hodgkin/Reed-Sternberg (HRS) cells in lymph node biopsies classical Hodgkin lymphoma (cHL) complicates the analysis somatic genetic alterations HRS cells. As circulating cell-free DNA (cfDNA) contains tumor (ctDNA) from cells, we prospectively collected cfDNA 177 patients with newly diagnosed, mostly early-stage cHL a monocentric study at Leuven, Belgium (n = 59) and multicentric BREACH by Lymphoma Study Association 118). To catalog patterns frequencies genomic...
Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas with poor prognosis. Up to 30% PTCL lack distinctive features and are classified as PTCL, not otherwise specified (PTCL-NOS). To further improve our understanding the genetic landscape biology PTCL-NOS, we perform RNA-sequencing 18 cases validate results in an independent cohort 37 cases. We identify FYN-TRAF3IP2, KHDRBS1-LCK SIN3A-FOXO1 new in-frame fusion transcripts, FYN-TRAF3IP2 recurrent detected 8 55...
We performed a phase I-II trial of escalating doses cisplatin (CDDP: 50-100 mg/m2 per course) plus carboplatin (CBDCA: 300-400 as potential way in which to maximize platinum without causing excessive toxic effects patients with advanced ovarian cancer. Thirty-three nonoptimally debulked disease FIGO (International Federation Gynecology and Obstetrics) stages IIc-IV [median age: 60 yr; median WHO (World Health Organization) performance status: 2; no prior chemotherapy] received six courses...
Breast-implant associated (BIA) lymphoma is an infrequent type of cancer occurring in the fluid and fibrous capsule around a textured breast implant. Recently, both 2022 WHO 5th edition classification Haematological tumours (WHO HAEM5) International Consensus Classification Mature Lymphoid Neoplasms (22ICC), recognized implant-associated Anaplastic Large Cell Lymphoma (BIA-ALCL) as definitive entity, defined mature CD30-positive T-cell lymphoma, confined by capsule, implant setting. Only few...
<title>Abstract</title> Multiplexing, labeling for multiple immunostains the very same cell or tissue section in situ, is of considerable interest. The major obstacles to diffusion this technique are high costs custom antibodies and instruments, low throughput, scarcity specialized skills facilities. We have validated detail here a method based on common primary secondary antibodies, diffusely available fluorescent image scanners routinely processed sections \(FFPE). It entails rounds...
The emergence of immune checkpoint inhibitors has dramatically changed the therapeutic landscape for patients with advanced melanoma. However, relatively low response rates and a high incidence severe immune-related adverse events have prompted search predictive biomarkers. A positive value been attributed to aberrant expression Human Leukocyte Antigen-DR (HLA-DR) by melanoma cells, but it remains unknown why this is case. In study, we examined microenvironment HLA-DR metastatic samples...
What's new in protocol Version 5: an expanded troubleshooting section, more validated antibodies) Multiplexing, labeling for multiple immunostains the very same cell or tissue section situ, is of considerable interest.The major obstacles to diffusion this technique are high costs custom antibodies and instruments, low throughput, scarcity specialized skills facilities.We have detail here a method based on common primary secondary antibodies, diffusely available uorescent image scanners...
<title>Abstract</title> <italic>(What’s new in protocol Version 5: an expanded troubleshooting section, more validated antibodies)</italic>Multiplexing, labeling for multiple immunostains the very same cell or tissue section situ, is of considerable interest. The major obstacles to diffusion this technique are high costs custom antibodies and instruments, low throughput, scarcity specialized skills facilities. We have detail here a method based on common primary secondary antibodies,...