A5040894632- Clinical Nutrition and Gastroenterology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Electrolyte and hormonal disorders
- Nutrition and Health in Aging
- Sepsis Diagnosis and Treatment
- Diet and metabolism studies
- Diabetes Management and Research
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Autophagy in Disease and Therapy
- Acute Kidney Injury Research
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Diabetes and associated disorders
- Venous Thromboembolism Diagnosis and Management
- Renal function and acid-base balance
- Cardiac Arrest and Resuscitation
- SARS-CoV-2 and COVID-19 Research
- Organ Transplantation Techniques and Outcomes
- Invertebrate Taxonomy and Ecology
- Adrenal Hormones and Disorders
- Dietary Effects on Health
- Parathyroid Disorders and Treatments
- Metabolism and Genetic Disorders
- Transplantation: Methods and Outcomes
KU Leuven
2016-2025
American Society for Parenteral and Enteral Nutrition
2023-2024
John Wiley & Sons (United States)
2023-2024
Universitair Ziekenhuis Leuven
2022-2024
Hudson Institute
2023-2024
UCLouvain
2024
Liechtenstein Institute
2024
Erasmus MC - Sophia Children’s Hospital
2023
Amsterdam University Medical Centers
2023
Ghent University Hospital
2022
Highlights•A postmortem bedside surgical procedure was developed for COVID-19 and control patients•Ciliated cells are the main target cell type SARS-CoV-2 in respiratory mucosa•Sustentacular (non-neuronal) olfactory mucosa•No evidence infection of sensory neurons or bulb parenchymaSummaryAnosmia, loss smell, is a common often sole symptom COVID-19. The onset sequence pathobiological events leading to dysfunction remains obscure. Here, we have harvest endoscopically samples mucosae whole...
Abstract How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated. Here, we perform single-cell deep-immune profiling of bronchoalveolar lavage (BAL) samples from 5 patients with mild 26 critical in comparison BALs non-COVID-19 pneumonia normal lung. We use pseudotime inference build T-cell monocyte-to-macrophage trajectories model gene expression changes along them. In COVID-19, CD8 + resident-memory (T RM ) CD4...
Epidemiological and clinical reports indicate that SARS-CoV-2 virulence hinges upon the triggering of an aberrant host immune response, more so than on direct virus-induced cellular damage. To elucidate immunopathology underlying COVID-19 severity, we perform cytokine multiplex profiling in patients. We show hypercytokinemia differs from interferon-gamma-driven storm macrophage activation syndrome, is pronounced critical versus mild-moderate COVID-19. Systems modelling levels paired with...
Gastrointestinal (GI) dysfunction is frequent in the critically ill but can be overlooked as a result of lack standardization diagnostic and therapeutic approaches. We aimed to develop research agenda for GI future research. systematically reviewed current knowledge on broad range subtopics from specific viewpoint dysfunction, highlighting remaining areas uncertainty suggesting studies.This systematic scoping review was conducted following successive steps: (1) identify clinically important...
Randomized, controlled trials have shown both benefit and harm from tight blood-glucose control in patients the intensive care unit (ICU). Variation use of early parenteral nutrition insulin-induced severe hypoglycemia might explain this inconsistency. Download a PDF Research Summary. We randomly assigned patients, on ICU admission, to liberal glucose (insulin initiated only when level was >215 mg per deciliter [>11.9 mmol liter]) or (blood-glucose targeted with LOGIC-Insulin algorithm at 80...
Abstract Context: Responses to critical illness, such as excessive inflammation and hyperglycemia, may trigger detrimental chain reactions that damage cellular proteins organelles. Such responses illness contribute the risk of (nonresolving) multiple organ dysfunction adverse outcome. Objective: We studied autophagy a bulk degradation pathway able remove toxic protein aggregates damaged organelles how these are affected by preventing hyperglycemia with insulin during illness. Design Setting:...
Muscular and hepatic abnormalities observed in artificially fed critically ill patients strikingly resemble the phenotype of autophagy-deficient mice. Autophagy is only pathway to clear damaged organelles large ubiquitinated proteins aggregates. Fasting its strongest physiological trigger. Severity autophagy deficiency correlated with amount infused amino acids. We hypothesized that impaired could partly be evoked by early provision parenteral nutrition enriched acids clinically used...
Increasing evidence implicates mitochondrial dysfunction as an early, important event in the pathogenesis of critical illness-induced multiple organ failure. We previously demonstrated that prevention hyperglycemia limits damage to mitochondria vital organs, thereby reducing morbidity and mortality. now hypothesize inadequate activation repair processes (clearance damaged by autophagy, fusion/fission, biogenesis) may contribute accumulation damage, persistence failure, adverse outcome...
A poor nutritional state and a caloric deficit associate with increased morbidity mortality, but recent multicenter, randomized controlled trial found that early parenteral nutrition to supplement insufficient enteral increases in the intensive care unit, including prolonging duration of renal replacement therapy, compared withholding for 1 week. Whether versus late impacts incidence recovery AKI is unknown. Here, we report prespecified analysis from this trial, Early Parenteral Nutrition...
Understanding the pathology of COVID-19 is a global research priority. Early evidence suggests that respiratory microbiome may be playing role in disease progression, yet current studies report contradictory results. Here, we examine potential confounders by analyzing upper (n = 58) and lower 35) tract well-phenotyped patients controls combining sequencing, viral load determination, immunoprofiling. We find time intensive care unit type oxygen support, as well associated treatments such...
Can SARS-CoV-2 hitchhike on the olfactory projection and take a direct short route from nose into brain? We reasoned that neurotropic or neuroinvasive capacity of virus, if it exists, should be most easily detectable in individuals who died an acute phase infection. Here, we applied postmortem bedside surgical procedure for rapid procurement tissue, blood, cerebrospinal fluid samples deceased COVID-19 patients infected with Delta, Omicron BA.1, BA.2 variants. Confocal imaging sections...
Acute kidney injury (AKI) has been reported as a frequent complication of critical COVID-19. We aimed to evaluate the occurrence AKI and use replacement therapy (KRT) in COVID-19, assess patient outcomes risk factors for differences outcome when diagnosis is based on urine output (UO) or serum creatinine (sCr).