Christophe Dooms
A5028699633- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Radiomics and Machine Learning in Medical Imaging
- Pleural and Pulmonary Diseases
- Lung Cancer Research Studies
- Medical Imaging Techniques and Applications
- Cancer Genomics and Diagnostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Immunotherapy and Biomarkers
- Respiratory Support and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Colorectal Cancer Treatments and Studies
- Airway Management and Intubation Techniques
- Transplantation: Methods and Outcomes
- Gastric Cancer Management and Outcomes
- COVID-19 Clinical Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal Cancer Research and Treatment
- Occupational and environmental lung diseases
- Advanced Radiotherapy Techniques
- RNA modifications and cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
KU Leuven
2016-2025
Universitair Ziekenhuis Leuven
2014-2023
Respiratory Clinical Trials
2014-2020
Breathe California of Sacramento Emigrant Trails
2020
European Respiratory Society
2017
Royal Brompton Hospital
2017
University Hospital Heidelberg
2017
Heidelberg University
2017
Institut de Cancérologie de l'Ouest
2016
Hospital de Cruces
2016
Accurate preoperative staging and restaging of mediastinal lymph nodes in patients with potentially resectable non-small-cell lung cancer (NSCLC) is paramount importance. In 2007, the European Society Thoracic Surgeons (ESTS) published an algorithm on integrating imaging, endoscopic surgical techniques. 2009, International Association for Study Lung Cancer (IASLC) introduced a new node map. Some changes this map have important impact staging. Moreover, more evidence different technique has...
Mediastinal nodal staging is recommended for patients with resectable non-small cell lung cancer (NSCLC). Surgical has limitations, which results in the performance of unnecessary thoracotomies. Current guidelines acknowledge minimally invasive endosonography followed by surgical (if no metastases are found endosonography) as an alternative to immediate staging.To compare 2 strategies.Randomized controlled multicenter trial (Ghent, Leiden, Leuven, Papworth) conducted between February 2007...
Among patients with resectable early-stage non–small-cell lung cancer (NSCLC), a perioperative approach that includes both neoadjuvant and adjuvant immune checkpoint inhibition may provide benefit beyond either alone. Download PDF of the Research Summary. We conducted randomized, double-blind, phase 3 trial to evaluate pembrolizumab in NSCLC. Participants stage II, IIIA, or IIIB (N2 stage) NSCLC were assigned 1:1 ratio receive (200 mg) placebo once every weeks, each which was given...
Abstract How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated. Here, we perform single-cell deep-immune profiling of bronchoalveolar lavage (BAL) samples from 5 patients with mild 26 critical in comparison BALs non-COVID-19 pneumonia normal lung. We use pseudotime inference build T-cell monocyte-to-macrophage trajectories model gene expression changes along them. In COVID-19, CD8 + resident-memory (T RM ) CD4...
IntroductionImproved outcome has been shown in patients with synchronous oligometastatic (sOM) NSCLC when treated radical intent. As a uniform definition of sOM is lacking, we developed and diagnostic criteria by consensus process.MethodsA pan-European multidisciplinary group was established. Consensus questions were built on the basis current controversies, definitions extracted from survey, cases systematic review. This statement formulated during meeting.ResultsIt determined that relevant...
Epidemiological and clinical reports indicate that SARS-CoV-2 virulence hinges upon the triggering of an aberrant host immune response, more so than on direct virus-induced cellular damage. To elucidate immunopathology underlying COVID-19 severity, we perform cytokine multiplex profiling in patients. We show hypercytokinemia differs from interferon-gamma-driven storm macrophage activation syndrome, is pronounced critical versus mild-moderate COVID-19. Systems modelling levels paired with...
The early-generation ROS1 tyrosine kinase inhibitors (TKIs) that are approved for the treatment of fusion–positive non–small-cell lung cancer (NSCLC) have antitumor activity, but resistance develops in tumors, and intracranial activity is suboptimal. Repotrectinib a next-generation TKI with preclinical against cancers, including those mutations such as G2032R. Download PDF Research Summary. In this registrational phase 1–2 trial, we assessed efficacy safety repotrectinib patients advanced...
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary point, may be published when key planned co-primary or secondary analyses are not yet available. Trial Updates provide an opportunity to disseminate additional results from studies, in JCO elsewhere, for which point has already been reported.In longest follow-up, our knowledge, a KRASG12C inhibitor, we assessed long-term efficacy, safety, and biomarkers of...
Amivantamab-lazertinib significantly prolonged progression-free survival (PFS) versus osimertinib in patients with epidermal growth factor receptor (EGFR)-mutant advanced non-small-cell lung cancer [NSCLC; hazard ratio (HR) 0.70; P < 0.001], including those a history of brain metastases (HR 0.69). Patients TP53 co-mutations, detectable circulating tumor DNA (ctDNA), baseline liver metastases, and without ctDNA clearance on treatment have poor prognoses. We evaluated outcomes these high-risk...
Objective To assess the clinical effectiveness and cost-effectiveness of endosonography (followed by surgical staging if was negative), compared with standard alone, in patients non-small cell lung cancer (NSCLC) who are otherwise candidates for surgery curative intent. Design A prospective, international, open-label, randomised controlled study, a trial-based economic analysis. Setting Four centres: Ghent University Hospital, Belgium; Leuven Hospitals, Leiden Medical Centre, Netherlands;...
Anastomotic airway complications give rise to morbidity and mortality after lung transplantation. Knowledge about contributing factors helps in adopting diagnostic therapeutic strategies. Systematic endoscopic description classification play a key role. A retrospective analysis of all bronchial anastomoses between 2005 2013 was performed assess anastomotic associated variables. Treatment modalities outcome endobronchial surgical interventions are reported. The prevalence our cohort 11%....
Understanding the pathology of COVID-19 is a global research priority. Early evidence suggests that respiratory microbiome may be playing role in disease progression, yet current studies report contradictory results. Here, we examine potential confounders by analyzing upper (n = 58) and lower 35) tract well-phenotyped patients controls combining sequencing, viral load determination, immunoprofiling. We find time intensive care unit type oxygen support, as well associated treatments such...