A5090675321- Abdominal Surgery and Complications
- Cardiac Ischemia and Reperfusion
- Clinical Nutrition and Gastroenterology
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Nutrition and Health in Aging
- Intensive Care Unit Cognitive Disorders
- Appendicitis Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Electrolyte and hormonal disorders
- Abdominal vascular conditions and treatments
- Hernia repair and management
- Renal function and acid-base balance
- Antibiotics Pharmacokinetics and Efficacy
- Sepsis Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Hemodynamic Monitoring and Therapy
- Aortic Disease and Treatment Approaches
- Esophageal and GI Pathology
- Cardiac Imaging and Diagnostics
- Cardiac and Coronary Surgery Techniques
- Trauma and Emergency Care Studies
- Muscle and Compartmental Disorders
- Enhanced Recovery After Surgery
- SARS-CoV-2 and COVID-19 Research
Tartu University Hospital
2014-2025
University of Tartu
2014-2024
University of Tartu Natural History Museum and Botanical Garden
2020
University of Lucerne
2017
Creative Research Enterprises (United States)
2017
European Society of Anaesthesiology
2017
University of Copenhagen
2017
North Estonia Medical Centre
2010
Intensive Care Society
2006
University of Antwerp
2005
Acute gastrointestinal (GI) dysfunction and failure have been increasingly recognized in critically ill patients. The variety of definitions proposed the past has led to confusion difficulty comparing one study another. An international working group convened standardize for acute GI symptoms review therapeutic options.
To identify the prevalence, risk factors, and outcomes of intra-abdominal hypertension in a mixed multicenter ICU population.Prospective observational study.Fifteen ICUs worldwide.Consecutive adult patients with bladder catheter.None.Four hundred ninety-one were included. Intra-abdominal pressure was measured minimum every 8 hours. Subjects mean equal to or greater than 12 mm Hg defined as having hypertension. present 34.0% on day admission (159/467) 48.9% (240/491) during observation...
Gastrointestinal (GI) dysfunction is frequent in the critically ill but can be overlooked as a result of lack standardization diagnostic and therapeutic approaches. We aimed to develop research agenda for GI future research. systematically reviewed current knowledge on broad range subtopics from specific viewpoint dysfunction, highlighting remaining areas uncertainty suggesting studies.This systematic scoping review was conducted following successive steps: (1) identify clinically important...
Abstract Background The aim of this multicentre prospective observational study was to identify the incidence, patient characteristics, diagnostic pathway, management and outcome acute mesenteric ischaemia (AMI). Methods All adult patients with clinical suspicion AMI admitted or transferred 32 participating hospitals from 06.06.2022 05.04.2023 were included. Participants who subsequently shown not have had localized intestinal gangrene due strangulating bowel obstruction only baseline data...
There are no universally accepted diagnostic criteria for gastrointestinal failure in critically ill patients. In the present study we tested whether occurrence of food intolerance (FI) and intra-abdominal hypertension (IAH), combined a 5-grade scoring system assessment function (the Gastrointestinal Failure [GIF] score), predicts mortality. The prognostic value GIF score alone combination with Sequential Organ Assessment (SOFA) is evaluated, incidence outcome described relative to score.A...
Background: Gastrointestinal (GI) problems are not uniformly assessed in intensive care unit (ICU) patients and respective data available literature insufficient. We aimed to describe the prevalence, risk factors importance of different GI symptoms. Methods: prospectively studied all hospitalized General ICU Tartu University Hospital 2004–2007. Results: Of 1374 patients, 62 were excluded due missing data. Seven hundred seventy‐five (59.1%) had at least one symptom during 1 day their stay,...
The study aimed to develop a gastrointestinal (GI) dysfunction score predicting 28-day mortality for adult patients needing mechanical ventilation (MV). 377 from 40 ICUs with expected duration of MV at least 6 h were prospectively studied. Predefined GI symptoms, intra-abdominal pressures (IAP), feeding details, organ and treatment documented on days 1, 2, 4 7. number simultaneous symptoms was higher in nonsurvivors each day. Absent bowel sounds bleeding the most significantly associated...
The incidence of postoperative complications and death is low in the general population, but a subgroup high-risk patients can be identified amongst whom adverse outcomes occur more frequently. present study was undertaken to describe complications, length stay, mortality after major abdominal surgery for gastrointestinal, hepatobiliary pancreatic malignancies identify risk factors impaired outcome.Data patients, operated on gastro-intestinal during 2009-2010 were retrieved from clinical...
The DIANA study aimed to evaluate how often antimicrobial de-escalation (ADE) of empirical treatment is performed in the intensive care unit (ICU) and estimate effect ADE on clinical cure day 7 following initiation. Adult ICU patients receiving therapy for bacterial infection were studied a prospective observational from October 2016 until May 2018. was defined as (1) discontinuation an case combination or (2) replacement with intention narrow spectrum, within first 3 days therapy. Inverse...
SummaryBackground & aimsTo develop a five grade score (0–4 points) for the assessment of gastrointestinal (GI) dysfunction in adult critically ill patients.MethodsThis prospective multicenter observational study enrolled consecutive patients admitted to 11 intensive care units nine countries. At all sites, daily clinical data with emphasis on GI symptoms were collected and intra-abdominal pressure measured. In out biomarkers citrulline intestinal fatty acid-binding protein (I-FABP) measured...
While gastrointestinal problems are common in ICU patients with multiple organ failure, failure has not been given the consideration other systems receive. The aim of this study was to evaluate incidence (GIF), identify its risk factors, and determine association mortality. A retrospective analysis adult (n = 2588) admitted three different ICUs (two at university hospital Charité-Universitätsmedizin Berlin, Germany one Tartu University Clinics, Estonia) during year 2002 performed. Data...
Background: Intra-abdominal hypertension (IAH) in intensive care patients is associated with an adverse outcome, but the risk factors for development of IAH have not been extensively studied. We aimed to identify independent mechanically ventilated (MV) patients. Methods: In this prospective observational study, 563 MV staying general unit (ICU) a university hospital more than 24 h were observed during their ICU stay. Repeated intermittent measurements intra-abdominal pressure (IAP) via...
Our objective was to describe the pharmacokinetics of meropenem in peritoneal fluid (PF) six patients with severe peritonitis and septic shock relate measured concentrations minimum inhibitory concentration bacteria. Microdialysis catheters were placed into space during surgery. Meropenem plasma PF analyzed using compartmental modeling. areas under concentration–time curve lower than (average ratio, 73.8±15%) because degradation confirmed ex vivo. Compartment modeling elimination from a...