A5074556836- Clinical Nutrition and Gastroenterology
- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Diet and metabolism studies
- Electrolyte and hormonal disorders
- Metabolism and Genetic Disorders
- Renal function and acid-base balance
- Abdominal Surgery and Complications
- Sepsis Diagnosis and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Sulfur Compounds in Biology
- Hemodynamic Monitoring and Therapy
- Exercise and Physiological Responses
- Mitochondrial Function and Pathology
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Cardiac Arrest and Resuscitation
- Enhanced Recovery After Surgery
- Growth Hormone and Insulin-like Growth Factors
- Pharmacological Effects and Toxicity Studies
Karolinska Institutet
2015-2025
Karolinska University Hospital
2015-2025
Swedish Research Council
1996-2017
Medical Research Council
2017
KU Leuven
2014
Research Foundation - Flanders
2014
Flemish Government
2014
Werner-Wicker-Klinik
1996-2013
Stockholm University
1989-2013
Centre Hospitalier Universitaire de Liège
2003-2012
Blood transfusions are frequently given to patients with septic shock. However, the benefits and harms of different hemoglobin thresholds for transfusion have not been established.In this multicenter, parallel-group trial, we randomly assigned in intensive care unit (ICU) who had shock a concentration 9 g per deciliter or less receive 1 leukoreduced red cells when level was 7 (lower threshold) (higher during ICU stay. The primary outcome measure death by 90 days after randomization.We...
HAMMARQVIST, FOLKE M.D.; WERNERMAN, JAN M.D., PH.D.; ALI, RUSTOM DER DECKEN, ALEXANDRA VON VINNARS, ERIK PH.D. Author Information
Gastrointestinal (GI) dysfunction is frequent in the critically ill but can be overlooked as a result of lack standardization diagnostic and therapeutic approaches. We aimed to develop research agenda for GI future research. systematically reviewed current knowledge on broad range subtopics from specific viewpoint dysfunction, highlighting remaining areas uncertainty suggesting studies.This systematic scoping review was conducted following successive steps: (1) identify clinically important...
Critically ill patients treated for multiple organ failure often develop muscle dysfunction. Here we test the hypothesis that mitochondrial and energy metabolism are deranged in leg intercostal of critically with sepsis-induced failure. Ten suffering from requiring mechanical ventilation were included study. A group (n = 10) metabolically healthy age- sex-matched undergoing elective surgery used as controls. Muscle biopsies obtained vastus lateralis (leg) muscle. The activities citrate...
Glutamine depletion is demonstrated to be an independent predictor of hospital mortality in ICU (intensive care unit) patients. Today glutamine supplementation recommended patients on parenteral nutrition. In addition glutamine, glutathione may a limiting factor with MOF (multiple organ failure). To study the prevalence and observational was performed. The results were analysed relation conventional predictors outcome, APACHE II (Acute Physiology Chronic Health Evaluation II) SOFA...
Septic patients treated in the intensive care unit (ICU) often develop multiple organ failure including persistent skeletal muscle dysfunction which results patient's protracted recovery process. We have demonstrated that mitochondrial enzyme activities are impaired septic ICU impairing cellular energy balance, will interfere with function and metabolism. Here we use detailed phenotyping genomics to elucidate mechanisms leading these impairments molecular consequences.Utilising biopsy...
Muscle wasting negatively affects morbidity and mortality in critically ill patients. This progressive is accompanied by, general, a normal muscle PS (protein synthesis) rate. In the present study, we investigated whether protein degradation increased patients with sepsis which proteolytic enzyme systems are involved this degradation. Eight seven healthy volunteers were studied. vivo kinetics was measured using arteriovenous balance techniques stable isotope tracers. The activities of major...
Background: Low plasma glutamine concentration is an independent prognostic factor for unfavourable outcome in the intensive care unit (ICU). Intravenous (i.v.) supplementation with reported to improve outcome. In a multi-centric, double-blinded, controlled, randomised, pragmatic clinical trial of i.v. ICU patients, we investigated outcomes regarding sequential organ failure assessment (SOFA) scores and mortality. The hypothesis was that change SOFA score would be improved by...
The International Protein Summit in 2016 brought experts clinical nutrition and protein metabolism together from around the globe to determine impact of high‐dose administration on outcomes address barriers its delivery critically ill patient. It has been suggested that high doses range 1.2–2.5 g/kg/d may be required setting intensive care unit (ICU) optimize therapy reduce mortality. While incapable blunting catabolic response, this needed best stimulate new synthesis preserve muscle mass....
SummaryBackground & aimsTo develop a five grade score (0–4 points) for the assessment of gastrointestinal (GI) dysfunction in adult critically ill patients.MethodsThis prospective multicenter observational study enrolled consecutive patients admitted to 11 intensive care units nine countries. At all sites, daily clinical data with emphasis on GI symptoms were collected and intra-abdominal pressure measured. In out biomarkers citrulline intestinal fatty acid-binding protein (I-FABP) measured...
Glutathione is quantitatively the most important endogenous scavenger system. depletion in skeletal muscle pronounced following major trauma and sepsis intensive care unit patients. Also, elective surgery, glutathione occurs parallel with a progressive decline glutamine concentration. The present study was designed to test hypothesis that supplementation may counteract human model. A homogeneous group of patients (n = 17) undergoing standardized surgical procedure were prospectively randomly...