A5053119129- Sepsis Diagnosis and Treatment
- Blood transfusion and management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemodynamic Monitoring and Therapy
- Blood donation and transfusion practices
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Arrest and Resuscitation
- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Hemoglobinopathies and Related Disorders
- Emergency and Acute Care Studies
- Heart Failure Treatment and Management
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Anesthesia and Neurotoxicity Research
- Nausea and vomiting management
- Intensive Care Unit Cognitive Disorders
- Platelet Disorders and Treatments
- Nosocomial Infections in ICU
- Respiratory Support and Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Endometriosis Research and Treatment
- Blood groups and transfusion
Copenhagen University Hospital
2012-2024
Rigshospitalet
2014-2024
University of Copenhagen
2014-2017
Lars Research Institute
2016
Holbæk Sygehus
2011-2014
Haukeland University Hospital
2014
Aalborg University Hospital
2014
Aarhus University Hospital
2014
Hvidovre Hospital
2011-2014
University of Helsinki
2014
Hydroxyethyl starch (HES) [corrected] is widely used for fluid resuscitation in intensive care units (ICUs), but its safety and efficacy have not been established patients with severe sepsis.In this multicenter, parallel-group, blinded trial, we randomly assigned sepsis to the ICU either 6% HES 130/0.42 (Tetraspan) or Ringer's acetate at a dose of up 33 ml per kilogram ideal body weight day. The primary outcome measure was death end-stage kidney failure (dependence on dialysis) 90 days after...
Blood transfusions are frequently given to patients with septic shock. However, the benefits and harms of different hemoglobin thresholds for transfusion have not been established.In this multicenter, parallel-group trial, we randomly assigned in intensive care unit (ICU) who had shock a concentration 9 g per deciliter or less receive 1 leukoreduced red cells when level was 7 (lower threshold) (higher during ICU stay. The primary outcome measure death by 90 days after randomization.We...
By tradition colloid solutions have been used to obtain fast circulatory stabilisation in shock, but high molecular weight hydroxyethyl starch (HES) may cause acute kidney failure patients with severe sepsis. Now lower HES 130/0.4 is the preferred Scandinavian intensive care units (ICUs) and 1st choice fluid for However, largely unstudied The 6S trial will randomise 800 sepsis 30 ICUs masked resuscitation using either 6% Ringer's acetate or alone. composite endpoint of 90-day mortality...
Intensive care unit (ICU) mortality prediction scores deteriorate over time, and their complexity decreases clinical applicability commonly causes problems with missing data. We aimed to develop internally validate a new simple score that predicts 90-day in adults upon acute admission the ICU: Simplified Mortality Score for Care Unit (SMS-ICU).We used data from an international cohort of 2139 patients acutely admitted ICU 1947 severe sepsis/septic shock 2009 2016. performed multiple...
Transfusion of red blood cells (RBC) is recommended in septic shock and the majority these patients receive RBC transfusion intensive care unit (ICU). However, benefit harm RBCs have not been established this group high-risk patients. The Requirements Septic Shock (TRISS) trial a multicenter with assessor-blinded outcome assessment, randomising 1,000 30 Scandinavian ICUs to pre-storage leuko-depleted suspended saline-adenine-glucose mannitol (SAGM) at haemoglobin level (Hb) 7 g/dl or 9 g/dl,...
Patients with malignant haematological disease and especially those who require intensive care have an increased risk of bleeding thrombosis, but none these data were obtained in ICU patients only. We assessed the incidence thrombotic complications, use blood products factors for adult population malignancies. screened all acute leukaemia myelodysplastic syndrome admitted to a university hospital during 2008–2012. Bleeding was scored according WHO grading system, evaluated using unadjusted...
Background Using a restrictive transfusion strategy appears to be safe in sepsis, but there may subgroups of patients who benefit from at higher haemoglobin level. We explored if with septic shock and anaemia had better outcome when transfused vs. lower threshold. Methods In post‐hoc analyses the full trial population 998 Transfusion Requirements Septic Shock ( TRISS ) trial, we investigated intervention effect on 90‐day mortality severe comorbidity (chronic lung disease, haematological...
Background Transfusion of red blood cells ( RBCs ) remains controversial in patients with septic shock, but current practice is unknown. Our aim was to evaluate RBC transfusion shock the intensive care unit ICU ), and patient characteristics outcome associated transfusion. Methods Prospective cohort study all adult n = 164) six general ICUs during a 3‐month period. Characteristics, other treatments, monitoring were compared ‐transfused ‐non‐transfused patients. Results Ninety‐nine (95%...
Abstract Background Transfusion of red blood cells (RBC) to rapidly increase hemoglobin levels have been associated with increased risks and worse outcomes in critically ill children. The international TAXI consensus from 2018 (pediatric critical care transfusion anemia expertise initiative) recommended restrictive RBC strategies pediatric patients. Objective To elucidate physicians perioperative trigger for patients the Nordic countries investigate what factors influence decision transfuse...
Supplemental oxygen therapy is used for intensive care (ICU) patients with severe sepsis, but no general guidelines and few safety data. The aim of this observational study was to describe the variability in administration as well association between partial pressure arterial (PaO2 ) mortality.We extracted data from two Scandinavian clinical trials ICU sepsis or septic shock. We calculated average PaO2 fraction inspired (FiO2 trial inclusion following 5 days, assessed 90-day mortality.The...
Introduction Mortality prediction scores are widely used in intensive care units (ICUs) and research, but their predictive value deteriorates as age. Existing mortality imprecise complex, which increases the risk of missing data decreases applicability bedside daily clinical practice. We propose development validation a new, simple updated rule: Simplified Score for use Intensive Care Unit (SMS-ICU). Methods analysis During first phase study, we will develop internally validate rule that...
Background The Simplified Mortality Score for the Intensive Care Unit (SMS‐ICU) is a clinical prediction model, which estimates risk of 90‐day mortality in acutely ill adult ICU patients using 7 readily available variables. We aimed to externally validate SMS‐ICU and compare its discrimination with existing models used as outcome. Methods validated data from 3282 included Stress Ulcer Prophylaxis trial, randomised factors gastrointestinal bleeding prophylactic pantoprazole or placebo 33 ICUs...
Abstract Background We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study three independent cohorts from United States Scandinavia consisting adults septic shock. compared mortality across within each pooled results meta-analysis. also estimated incidence AKI degree damage, as measured by concentrations soluble thrombomodulin...
BACKGROUND The effects of anemia and red blood cell (RBC) transfusion on markers clot formation platelet function in patients with septic shock are unknown. We assessed these a randomized trial shock. STUDY DESIGN AND METHODS performed prospective substudy the Transfusion Requirements Septic Shock (TRISS) trial, randomly assigning intensive care unit hemoglobin concentration 9.0 g/dL or less to one RBCs at level 7.0 g/dL. thromboelastography (TEG), multiple electrode aggregometry (MEA),...