A5014534891- Sepsis Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma and Emergency Care Studies
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Atrial Fibrillation Management and Outcomes
- Blood transfusion and management
- COVID-19 Clinical Research Studies
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Intensive Care Unit Cognitive Disorders
- Acute Kidney Injury Research
- Long-Term Effects of COVID-19
- Traumatic Brain Injury and Neurovascular Disturbances
- Health Systems, Economic Evaluations, Quality of Life
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Nosocomial Infections in ICU
- Renal function and acid-base balance
- Clinical Reasoning and Diagnostic Skills
- Meta-analysis and systematic reviews
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- COVID-19 and healthcare impacts
Rigshospitalet
2015-2025
University of Copenhagen
2009-2024
Copenhagen University Hospital
2013-2023
Roskilde Sygehus
2015
Hydroxyethyl starch (HES) [corrected] is widely used for fluid resuscitation in intensive care units (ICUs), but its safety and efficacy have not been established patients with severe sepsis.In this multicenter, parallel-group, blinded trial, we randomly assigned sepsis to the ICU either 6% HES 130/0.42 (Tetraspan) or Ringer's acetate at a dose of up 33 ml per kilogram ideal body weight day. The primary outcome measure was death end-stage kidney failure (dependence on dialysis) 90 days after...
Blood transfusions are frequently given to patients with septic shock. However, the benefits and harms of different hemoglobin thresholds for transfusion have not been established.In this multicenter, parallel-group trial, we randomly assigned in intensive care unit (ICU) who had shock a concentration 9 g per deciliter or less receive 1 leukoreduced red cells when level was 7 (lower threshold) (higher during ICU stay. The primary outcome measure death by 90 days after randomization.We...
Importance Supplemental oxygen is ubiquitously used in patients with COVID-19 and severe hypoxemia, but a lower dose may be beneficial. Objective To assess the effects of targeting Pa o 2 60 mm Hg vs 90 hypoxemia intensive care unit (ICU). Design, Setting, Participants Multicenter randomized clinical trial including 726 adults receiving at least 10 L/min or mechanical ventilation 11 ICUs Europe from August 2020 to March 2023. The was prematurely stopped prior outcome assessment due slow...
Patients with severe sepsis often present concurrent coagulopathy, microcirculatory failure and evidence of vascular endothelial activation damage. Given the critical role endothelium in balancing hemostasis, we investigated single-point associations between whole blood coagulopathy by thrombelastography (TEG) plasma/serum markers damage patients sepsis.A post-hoc multicenter prospective observational study a subgroup 184 from Scandinavian Starch for Severe Sepsis/Septic Shock (6S) Trial....
Most data on intensive care unit (ICU) patients with COVID-19 originate in selected populations from stressed healthcare systems shorter term follow-up. We present characteristics, interventions and longer outcomes of the entire, unselected cohort all ICU Denmark where capacity was not exceeded.We identified SARS-CoV-2 admitted to any Danish 10 March 19 May 2020 registered demographics, chronic comorbidities, use organ support, length stay, vital status patient files. Risk factors for death...
To assess the incidence, risk factors, and outcomes of atrial fibrillation (AF) in ICU to describe current practice management AF.Multicenter, prospective, inception cohort study.Forty-four ICUs 12 countries four geographical regions.Adult, acutely admitted patients without a history persistent/permanent AF or recent cardiac surgery were enrolled; periods from October 2020 June 2021.None.We included 1,423 analyzed 1,415 (99.4%), among whom 221 had 539 episodes AF. Most (59%) diagnosed with...
By tradition colloid solutions have been used to obtain fast circulatory stabilisation in shock, but high molecular weight hydroxyethyl starch (HES) may cause acute kidney failure patients with severe sepsis. Now lower HES 130/0.4 is the preferred Scandinavian intensive care units (ICUs) and 1st choice fluid for However, largely unstudied The 6S trial will randomise 800 sepsis 30 ICUs masked resuscitation using either 6% Ringer's acetate or alone. composite endpoint of 90-day mortality...
Intensive care unit (ICU) mortality prediction scores deteriorate over time, and their complexity decreases clinical applicability commonly causes problems with missing data. We aimed to develop internally validate a new simple score that predicts 90-day in adults upon acute admission the ICU: Simplified Mortality Score for Care Unit (SMS-ICU).We used data from an international cohort of 2139 patients acutely admitted ICU 1947 severe sepsis/septic shock 2009 2016. performed multiple...
Transfusion of red blood cells (RBC) is recommended in septic shock and the majority these patients receive RBC transfusion intensive care unit (ICU). However, benefit harm RBCs have not been established this group high-risk patients. The Requirements Septic Shock (TRISS) trial a multicenter with assessor-blinded outcome assessment, randomising 1,000 30 Scandinavian ICUs to pre-storage leuko-depleted suspended saline-adenine-glucose mannitol (SAGM) at haemoglobin level (Hb) 7 g/dl or 9 g/dl,...
ICU admission due to COVID-19 may result in cognitive and physical impairment. We investigated the long-term status of Danish patients with COVID-19.We included all admitted ICUs between March 10 May 19, 2020. Patients were contacted prospectively at 6 12 months for follow-up. Our primary outcomes function frailty after admission, estimated by Mini Montreal Cognitive Assessment, Clinical Frailty Scale. Secondary 6- 12-month mortality, health-related quality life (HRQoL) assessed EQ-5D-5L,...
Abstract Aim To describe the use of invasive mechanical ventilation core strategies, adjuvant treatments and occurrence barotrauma prolonged in ICU patients with COVID‐19 Denmark, retrospectively. Methods All ICUs admitting Denmark from 10 March 2020 to 2 April 2021 were invited participate. who received included data was retrospectively collected electronic patient records. Results A total 774 invasively ventilated during first two waves included; 70% males median age 69 years. 340 (51.5%)...
Background: Simple diagnostic tests are needed to screen septic patients for low cardiac output because intervention is recommended in these patients. We assessed the value of central venous oxygen saturation superior vena cava (ScvO 2 ) detecting with shock. Methods: conducted a prospective observational study three general intensive care units (ICUs) adult shock, who were have catheter inserted thermodilution measurement index (CI TD ). Paired measurements CI and oximetry values obtained...
Background The predictive value of plasma and urine neutrophil gelatinase‐associated lipocalin ( NGAL ) for use renal replacement therapy RRT acute kidney injury AKI is not established in patients with severe sepsis. Methods This was a prospective observational study three general intensive care units ICUs adult ICU sepsis needing fluid resuscitation sub‐study the 6 S trial. Plasma were sampled at baseline measured using particle‐enhanced turbidimetric immunoassay (The T est). Outcome...
Background We aimed to detail the effects of hydroxyethyl starch ( HES ) vs. R inger's on kidney function including interaction with mortality in post‐hoc analyses as resuscitation 130/0.42 increased S candinavian tarch for evere epsis/ eptic hock (6 trial. Methods In all 798 randomised patients, we assessed incidence and effect acute injury AKI acetate groups using K idney D isease: I mproving G lobal O utcome criteria. also intervention time duration renal replacement therapy RRT )....