A5078273773- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Animal Ecology and Behavior Studies
- MicroRNA in disease regulation
- Wildlife Ecology and Conservation
- Ecology and Vegetation Dynamics Studies
- Cancer-related molecular mechanisms research
- Virus-based gene therapy research
- Immune Response and Inflammation
- Plant and animal studies
- Viral gastroenteritis research and epidemiology
- Gastrointestinal motility and disorders
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Dermatology and Skin Diseases
- Adrenal Hormones and Disorders
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Diabetes and associated disorders
- Tryptophan and brain disorders
- CAR-T cell therapy research
- Immunodeficiency and Autoimmune Disorders
Babraham Institute
2019-2025
University of Cambridge
2023-2025
University of Ulster
2025
VIB-KU Leuven Center for Brain & Disease Research
2017-2024
KU Leuven
2015-2024
Muskingum University
2008-2024
University of Kentucky
2024
Vlaams Instituut voor Biotechnologie
2012-2022
The Open University
2021
Universitair Ziekenhuis Leuven
2019
Thymectomy of neonatal mice can result in the development autoimmune pathology. It has been proposed that thymic output regulatory T (T reg) cells is delayed during ontogeny and disease neonatally thymectomized caused by escape self-reactive before thymectomy without accompanying reg cells. However, kinetics cell production within thymus not assessed. We demonstrate Foxp3-expressing substantially relative to nonregulatory thymocytes ontogeny. Based on our data, we speculate induction Foxp3...
A mutation in pyrin that disrupts regulation leads to autoinflammatory disease.
The brain is a site of relative immune privilege. Although CD4 T cells have been reported in the central nervous system, their presence healthy remains controversial, and function largely unknown. We used combination imaging, single cell, surgical approaches to identify CD69+ cell population both mouse human brain, distinct from circulating cells. brain-resident was derived through situ differentiation activated circulatory shaped by self-antigen peripheral microbiome. Single-cell sequencing...
Background Modulation and depletion strategies of regulatory T cells (Tregs) constitute valid approaches in antitumor immunotherapy but suffer from severe adverse effects due to their lack selectivity for the tumor-infiltrating (ti-)Treg population, indicating need a ti-Treg specific biomarker. Methods We employed single-cell RNA-sequencing mouse model non-small cell lung carcinoma (NSCLC) obtain comprehensive overview T-cell compartment, with focus on subpopulations. These findings were...
The ability of immune-modulating biologics to prevent and reverse pathology has transformed recent clinical practice. Full utility in the neuroinflammation space, however, requires identification both effective targets for local immune modulation a delivery system capable crossing blood-brain barrier. characterization small population regulatory T (Treg) cells resident brain presents one such potential therapeutic target. Here, we identified interleukin 2 (IL-2) levels as limiting factor...
The tissues are the site of many important immunological reactions, yet how immune system is controlled at these sites remains opaque. Recent studies have identified Foxp3
The microRNA-29 (miR-29) family is among the most abundantly expressed microRNA in pancreas and liver. Here, we investigated function of miR-29 glucose regulation using miR-29a/b-1 (miR-29a)-deficient mice newly generated miR-29b-2/c (miR-29c)-deficient mice. We observed multiple independent functions family, which can be segregated into a hierarchical physiologic handling. miR-29a, not miR-29c, was to positive regulator insulin secretion vivo, with dysregulation exocytotic machinery...
Selective inhibition of γ-secretase complexes targets T-ALL without the dose-limiting side effects complete inhibition.
Abstract CD4 + regulatory T (Treg) cells, dependent upon the transcription factor Foxp3, contribute to tumour immunosuppression but are also required for immune homeostasis. There is interest in developing therapies that selectively target immunosuppressive function of Treg cells within tumours without disrupting their systemic anti‐inflammatory function. High levels expression chemokine (C‐C motif) receptor 8 (CCR8) discriminate from those found lymphoid tissues. It has recently been...
Abstract Hepatic fat accumulation is associated with diabetes and hepatocellular carcinoma (HCC). Here, we characterize the metabolic response that high-fat availability elicits in livers before disease development. After a short term on diet (HFD), otherwise healthy mice showed elevated hepatic glucose uptake increased contribution to serine pyruvate carboxylase activity compared control (CD) mice. This phenotype occurred independently from transcriptional or proteomic programming, which...
Ageing is the principal risk factor for retinal degenerative diseases, which are commonest cause of blindness in developed countries. These conditions include age-related macular degeneration or diabetic retinopathy. Regulatory T cells play a vital role immunoregulation nervous system by limiting inflammation and tissue damage health disease. Because retina was long-considered an immunoprivileged site, precise contribution regulatory homeostasis diseases remains unknown.
Abstract Myelin regeneration (remyelination) is essential to prevent neurodegeneration in demyelinating diseases such as Multiple Sclerosis, however, its efficiency declines with age. Regulatory T cells (Treg) recently emerged critical players tissue regeneration, including remyelination. However, the effect of ageing on Treg-mediated regenerative processes poorly understood. Here, we show that expansion aged Treg does not rescue age-associated remyelination impairment due an intrinsically...