A5078087258- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Drug Transport and Resistance Mechanisms
- Virus-based gene therapy research
- Gastrointestinal motility and disorders
- Immunotherapy and Immune Responses
- Inflammatory Bowel Disease
- Analytical Methods in Pharmaceuticals
- Microscopic Colitis
- Gold and Silver Nanoparticles Synthesis and Applications
- Helicobacter pylori-related gastroenterology studies
- Dendrimers and Hyperbranched Polymers
- Lipid Membrane Structure and Behavior
- Barrier Structure and Function Studies
- Analytical Chemistry and Chromatography
- DNA and Nucleic Acid Chemistry
- Viral gastroenteritis research and epidemiology
- MicroRNA in disease regulation
- Prostate Cancer Treatment and Research
- Genetic Neurodegenerative Diseases
- RNA Research and Splicing
- Pharmacological Effects and Toxicity Studies
University College Cork
2015-2024
Procter & Gamble (United States)
2024
Cork University Hospital
2024
National University of Ireland
2021
Ollscoil na Gaillimhe – University of Galway
2005-2019
Weatherford College
2014-2015
University College Dublin
2006
Mercy University Hospital
2006
Trinity College Dublin
1992-2005
Royal United Hospital
2003
Au nanoparticles with diameters ranging between 15 and 170 nm have been synthesised in aqueous solution using a seed-mediated growth method, employing hydroxylamine hydrochloride as reducing agent. Thiolated polyethylene glycol (mPEG-SH) polymers, molecular weights from 2100 to 51 000 g mol−1, were used efficient particle stabilising ligands. Dynamic light scattering zeta potential measurements confirmed that the overall mean diameter of capped increased non-linear way increasing weight...
The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy. However, despite great promise for a variety cancers, efficacy inhibitors is still low in colorectal (CRC). This mainly due to immunosuppressive feature tumor microenvironment (TME). Emerging evidence reveals that certain chemotherapeutic drugs induce immunogenic cell death (ICD), demonstrating potential remodeling TME. In this study, ginsenoside Rg3 (Rg3) as an ICD inducer against CRC...
Huntington's disease (HD) is a rare autosomal dominant neurodegenerative caused by the expression of toxic Huntingtin (HTT) protein. The use short interfering RNAs (siRNAs) to silence mutant protein one most promising therapeutic strategies under investigation. biggest caveat siRNA-based approaches lack efficient and nontoxic delivery vectors for siRNA central nervous system. In this study, we investigated potential modified amphiphilic β-cyclodextrins (CDs), oligosaccharide-based molecules,...
The gut microbiota influences host brain function, but the underlying gut-brain axis connections and molecular processes remain unclear. One pathway along this bidirectional communication system involves circulating microbially derived metabolites, such as short-chain fatty acids (SCFAs), which include butyrate propionate. Brain endothelium is main interface of between signals brain, it constitutes component blood-brain barrier (BBB). Here, we used a well-established in vitro BBB model...
Prostate cancer remains a serious condition threatening the health of men. Due to complicated nature tumour microenvironment (TME), conventional treatments face challenges including poor prognosis and resistance, therefore new therapeutic strategies are urgently needed. Small interfering RNA (siRNA), double-stranded non-coding RNA, regulates specific gene expression through interference. Tumour-associated macrophages (TAMs) potential target in immunotherapy. Colony stimulating...