A5057542174- Drug Solubulity and Delivery Systems
- Crystallization and Solubility Studies
- Advanced Drug Delivery Systems
- Pharmaceutical studies and practices
- Protein purification and stability
- Gastroesophageal reflux and treatments
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Drug Transport and Resistance Mechanisms
- Gastrointestinal motility and disorders
- Dysphagia Assessment and Management
- Antibiotics Pharmacokinetics and Efficacy
- Surfactants and Colloidal Systems
- Renal function and acid-base balance
- Pharmacogenetics and Drug Metabolism
- Celiac Disease Research and Management
- Esophageal and GI Pathology
- Spectroscopy and Chemometric Analyses
- Eosinophilic Esophagitis
- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects and Toxicity Studies
- Microencapsulation and Drying Processes
- Intestinal Malrotation and Obstruction Disorders
- Diet and metabolism studies
- Viral Infectious Diseases and Gene Expression in Insects
Roche (Switzerland)
2016-2024
University of Southern Denmark
2024
FHNW University of Applied Sciences and Arts
2011-2014
University of Basel
2011-2014
Abstract The effect of food on pharmacokinetic properties drugs is a commonly observed occurrence affecting about 40% orally administered drugs. Within the pharmaceutical industry, significant resources are invested to predict and characterize clinically relevant effect. Here, predictive performance physiologically based (PBPK) models was assessed via de novo mechanistic absorption for 30 compounds using controlled, pre-defined in vitro , modeling methodology. Compounds which known be...
Older adults represent the major target population for oral medications, due to high prevalence of multimorbidity. To allow successful pharmacological treatments, patients need adhere their medication and, thus, patient-centric drug products with a level acceptability by end users are needed. However, knowledge on appropriate size and shape solid dosage forms, as most commonly used forms in older adults, is still scarce. A randomized intervention study was performed including 52 (65 94...
Predicting the absorption of drugs from enabling formulations is still challenging due to limited capabilities standard physiologically based biopharmaceutics models (PBBMs) capture complex processes. Amongst others, it often assumed that both, molecularly and apparently dissolved drug in gastrointestinal lumen are prone absorption. A recently introduced method for measuring concentrations a dynamic vitro dissolution setup using microdialysis has opened new opportunities test this hypothesis...
Enabling drug formulations are often required to ensure sufficient absorption after oral administration of poorly soluble drugs. While these typically increase the apparent solubility drug, it is widely acknowledged that only molecularly dissolved, i.e., free fraction prone for direct absorption, while colloid-associated does not permeate same extent.In present study, we aimed at comparing effect and apparently (i.e., sum drug) dissolved concentrations on a water-soluble compound, Alectinib....
ABSTRACT Adult patients with anaplastic lymphoma kinase positive (ALK+) advanced non–small‐cell lung cancer (NSCLC) are treated 600 mg alectinib twice daily (BID) as first‐line treatment. ALK solid and central nervous system (CNS) tumors described in the pediatric population, limited clinical data due to rarity of disease challenges determine right dosing. This study aims inform dose recommendations for by performing a middle‐out physiologically based pharmacokinetic (PBPK) modeling...
Many new drug entities are poorly water-soluble and thus require solubility-enhancing formulations to ensure sufficient bioavailability. On the other hand, it is more accepted that not all "dissolved" states of a contribute equally enhanced absorption, i.e. an increase in apparent solubility does necessarily go parallel with molecularly dissolved drug, latter being regarded as key driving force for absorption. Our study aimed provide time-resolved information on dissolution, supersaturation,...
Tacrolimus is a crucial immunosuppressant for organ transplant patients, requiring therapeutic drug monitoring due to its variable exposure after oral intake. Physiologically based pharmacokinetic (PBPK) modelling has provided insights into tacrolimus disposition in adults but limited application paediatrics. This study investigated age dependency at the levels of absorption, metabolism, and distribution. Based on literature data, PBPK model was developed predict intravenous administration....
Amorphous solid dispersions (ASD) are increasingly used to improve the oral bioavailability of poorly water-soluble compounds. However, hydrophilic polymers in ASD have high water-binding properties and, upon water contact, they often form a gel on surface tablet, impacting rate and extent drug release. Most inorganic salts decrease solubility organic solutes, changing polymers. In this study, effect release from tablet formulation containing an itraconazole (ITZ)-hydroxypropyl methyl...
The majority of new drug entities exhibits poor water solubility and therefore enabling formulations are often needed to ensure sufficient in vivo bioavailability upon oral administration. Several vitro tools have been proposed for biopredictive screening such facilitate formulation development. Among these, combined dissolution/permeation (D/P) assays gained increasing interest recent years, since they presumed better predict the absorption behavior as compared single-compartment...