A5088018753- Graphene and Nanomaterials Applications
- Carbon and Quantum Dots Applications
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanocluster Synthesis and Applications
- biodegradable polymer synthesis and properties
- Biopolymer Synthesis and Applications
- Electrospun Nanofibers in Biomedical Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Dendrimers and Hyperbranched Polymers
- Graphene research and applications
- Bone Tissue Engineering Materials
- Hydrogels: synthesis, properties, applications
- Quantum Dots Synthesis And Properties
- Advanced biosensing and bioanalysis techniques
- Tissue Engineering and Regenerative Medicine
- Microbial Metabolites in Food Biotechnology
- Mesoporous Materials and Catalysis
- Advanced Drug Delivery Systems
- Luminescence and Fluorescent Materials
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Lipid Membrane Structure and Behavior
- Antimicrobial agents and applications
University of Palermo
2016-2025
Fondazione Umberto Veronesi
2018-2020
University of Milan
2012-2016
National Interuniversity Consortium of Materials Science and Technology
2013-2014
Carbon nanodots are known for their appealing optical properties, especially intense fluorescence tunable in the visible range. However, they often affected by considerable issues of and structural heterogeneity, which limit performance practical possibility applying these nanoparticles several fields. Here we developed a synthesis method capable producing unique variety carbon displaying an extremely high absorption strength (ε > 3 × 106 M(dot)−1 cm–1) quantum yield (73%). The homogeneity...
Here, mucus-penetrating nanoparticles (NPs) for pulmonary administration of ivacaftor in patients with cystic fibrosis (CF) were produced the dual aim enhancing delivery to airway epithelial cells, by rapid diffusion through mucus barrier, and at same time, promoting lung cellular uptake. Pegylated Tat-decorated fluorescent (FNPs) nanoprecipitation, starting from two synthetic copolymers, showed nanometric sizes (∼70 nm), a slightly negative ζ potential, high cytocompatibility toward human...
Very recent red-emissive carbon nanodots (CDs) have shown potential as near-infrared converting tools to produce local heat useful in cancer theranostics. Besides, CDs seem very appealing for clinical applications combining hyperthermia, imaging, and drug delivery a single platform capable of selectively targeting cells. However, still suffer from dramatic dot-to-dot variability issues such that rational design their structural, optical, chemical characteristics medical has been impossible...
Here, we reported the production of hyaluronic acid/polyaspartamide-based double-network nanogels for potential treatment colorectal carcinoma. Graphene oxide, thanks to huge aromatic surface area, allows easily load high amount irinotecan (33.0% w/w) and confers system hyperthermic properties when irradiated with a near-infrared (NIR) laser beam. We demonstrate that release antitumor drug is influenced both by pH external medium NIR irradiation process. In vitro biological studies,...
Here, a novel protonable copolymer was realized for the production of polyplexes with siRNA (inhibitor STAT6 expression in asthma), aim pulmonary administration. The polycation synthesized by derivatization α,β-poly(N-2-hydroxyethyl)d,l-aspartamide (PHEA) 1,2-Bis(3-aminopropylamino)ethane (bAPAE) proper conditions to obtain PHEA-g-bAPAE graft degree amine (DDbAPAE%) equal 35 mol%. showed buffering behavior, i.e., ranging between pH 5 and 7.4, potentially give endosomal escape obtained...
This study focuses on designing hybrid theranostic nanosystems, utilizing gadolinium-doped carbon nanodots decorated with bioreducible amphoteric polyamidoamines (PAAs). The objective is to synergize the exceptional properties of (CDs) siRNA complexation capabilities PAAs. Linear copolymeric polyamidoamines, based N,N′-bis(acryloyl)cystamine, arginine, and agmatine, were synthesized, resulting in three distinct copolymers. Notably, sulfur bridges within PAA repeating units confer pronounced...
Among the relevant properties of graphene derivatives, their ability acting as an energy-converting device so to produce heat (i.e., thermoablation and hyperthermia) was more recently taken into account for treatment solid tumors. In this pioneering study, first time, in vitro RGO-induced hyperthermia assessed combined with stimuli-sensitive anticancer effect a biotinylated inulin-doxorubicin conjugate (CJ-PEGBT), hence, getting nanosystem endowed synergic effects high specificity. CJ-PEGBT...
Carbon nanodots (CDs) are a new class of carbon-based nanoparticles endowed with photoluminescence, high specific surface area, and good photothermal conversion, which have spearheaded many breakthroughs in medicine, especially drug delivery cancer theranostics. However, the tight control their structural, optical, biological properties synthesis scale-up been very difficult so far. Here, we report for first time an efficient protocol one-step decagram-scale quantities N,S-doped CDs narrow...
This study focuses on the synthesis and characterization of gadolinium-doped carbon nanodots (CDs-Gd) their potential applications in multimodal imaging precision cancer therapy. CDs-Gd were synthesized through a solvothermal decomposition method combining citric acid, GdCl3, urea. The incorporation Gd3+ ions within carbonaceous structure resulted stable with peculiar architecture that retained optical paramagnetic properties. Combined techniques confirmed presence pH-sensitive COOH...
The design of hybrid nanosystems that integrate distinct optical and electronic properties in a synergistic way represents key challenge modern photonics. While few works have proposed to...
There are few therapeutic options to simultaneously tackle Staphylococcus aureus and Pseudomonas aeruginosa, two of the most relevant nosocomial antibiotic-resistant pathogens responsible for implant, catheters wound severe infections. The design synthesis polymers with inherent antimicrobial activity have gained increasing attention as a safe strategy treat multi-drug-resistant microbes. Here, we tested new polymeric derivative glycopolypeptide architecture (PAA-VC) bearing l-arginine,...
A novel folate-targeted gold-based nanosystem for achieving selectivity towards folate receptor (FR) positive cells is proposed, by virtue of the fact that FR a molecularly targeted entity overexpressed in wide spectrum solid tumors. new inulin-folate derivative (INU-FA) has been synthesized to act as coating agent 40 nm gold nanoparticles. The obtained polymer-coated nanoparticles (Au@INU-FA) were characterized terms hydrodynamic radius, shape, zeta potential, and aqueous stability loaded...
Femtosecond hole burning reveals the electronic structure and explains fluorescence tunability of carbon dot.
A linear amphoteric poly(amidoamino acid), L-ARGO7, is prepared by Michael-type polyaddition of L-arginine with N,N'-methylenebisacrylamide. Chain-extension acrylamide end-capped L-ARGO7 oligomers piperazine leads to high-molecular-weight copolymers in which maintains its absolute configuration. Acid/base properties polymers show isolectric points ≈ 10 and positive net average charges per repeating unit at pH = 7.4 from 0.25 0.40. These arginine-rich synthetic possibly share some the unique...