A5080206552- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- Hydrogels: synthesis, properties, applications
- Nanoplatforms for cancer theranostics
- Bone Tissue Engineering Materials
- Dendrimers and Hyperbranched Polymers
- Laser Applications in Dentistry and Medicine
- Pain Mechanisms and Treatments
- Nanocomposite Films for Food Packaging
- Nanoparticle-Based Drug Delivery
- Polydiacetylene-based materials and applications
- Polymer composites and self-healing
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advancements in Transdermal Drug Delivery
- Phytase and its Applications
- Advanced Nanomaterials in Catalysis
- Rheology and Fluid Dynamics Studies
- Opioid Use Disorder Treatment
- Graphene and Nanomaterials Applications
- Periodontal Regeneration and Treatments
- Photochromic and Fluorescence Chemistry
- Polysaccharides and Plant Cell Walls
- Polymer Surface Interaction Studies
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione
2024
University of Palermo
2020-2024
Ri.MED
2024
University College London
2017-2020
In this study, hydrogels were produced using a Schiff base reaction between two hyaluronic acid derivatives: one containing aldehyde groups (HA-Ald) and the other holding diethylenetriamine with terminal amino (HA-DETA). The DETA portion promotes in situ growth, complexation, stabilization of silver nanoparticles (AgNPs), eliminating need for external reducing agents. HA-DETA HA-Ald leads to formation imine bonds, which results dynamically pH-responsive cross-linking. While capping ability...
A series of four different low molecular weight gellan gum products was obtained by alkaline hydrolysis with the aim to investigate impact on rheological properties polysaccharide aqueous dispersions and physicochemical characteristics derived ionotropic crosslinked hydrogels. In particular, thermo-rheological analysis conducted study influence thermogelation typical native while strain sweep experiments were establish if dispersion shows a viscoelastic behavior. The effect Ca2+ hydrogels...
Superparamagnetic iron oxide nanoparticles (SPIONs) may act as an excellent theragnostic tool if properly coated and stabilized in a biological environment, even more, they have targeting properties towards specific cellular target. Humanized Archaeoglobus fulgidus Ferritin (HumAfFt) is engineered ferritin characterized by the peculiar salt-triggered assembly-disassembly of hyperthermophile successfully endowed with human H homopolymer recognition sequence transferrin receptor (TfR1 or...
Here, for the production of a bioink-based gellan gum, an amino derivative this polysaccharide was mixed with mono-functionalized aldehyde polyethyleneglycol in order to improve viscoelastic macroscopic properties and potential processability by means bioprinting techniques as confirmed printing tests. The dynamic Schiff base linkage between groups temporally modulates rheological allows reduction applied pressure during extrusion followed recovery gum strength. Rheological properties, often...
Abstract An alkyl functionalized gellan gum derivative is here used to produce hydrogels containing hydroxyapatite and tricalcium phosphate nanoparticles as injectable nanostructured scaffolds for bone regeneration. The amphiphilic nature of the polysaccharide along with its thermotropic behavior ionotropic crosslinking features make possible mimetic that can be release viable cells osteoinductive biomolecules. influence different concentration on rheological physicochemical properties...
The need to obtain solid adhesive scaffolds that can be processed create friendly microenvironments, direct cellular behaviors, and tissue regeneration is growing. A facile method was used incorporate a mussel-inspired moiety, dopamine, into segmented polyurethanes based on polycaprolactone–polyethylene glycol–polycaprolactone (PCL–PEG–PCL) copolymers. Dopamine chemically bonded lysine as chain extender biodegradable elastomer capable of strongly adhering different materials after melting...
With the aim to produce a cellularized construct for guided bone regeneration of dento-alveolar defects, here we porous scaffold using an amine derivative gellan gum host gingival mesenchymal stem cells (GMSCs) and allow their osteochondral differentiation. Three derivatives were produced by same synthetic procedure, viscoelastic properties aqueous dispersions investigated compared those native polysaccharide choose with suitable production. Freeze-drying was used obtain sponge that can be...
Loading anti-cancer drugs into 3D polymeric platforms is a promising strategy for achieving sustained release to solid cancer tissues while simultaneously prolonging device retention and promoting regeneration. In this study, we developed drug-loaded nanocomposite scaffold based on polyurethane urea (PUU) using the solvent-casting technique. The purpose was achieve local delivery redox-responsive of doxorubicin, thereby preventing bone recurrence in post-operative resection...