A5050965877- Neuroscience and Neuropharmacology Research
- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Carbohydrate Chemistry and Synthesis
- Cannabis and Cannabinoid Research
- Peroxisome Proliferator-Activated Receptors
- HIV Research and Treatment
- Sphingolipid Metabolism and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Bioactive Compounds and Antitumor Agents
- Protein Kinase Regulation and GTPase Signaling
- Nanoparticles: synthesis and applications
- Genetics and Neurodevelopmental Disorders
- Lipid Membrane Structure and Behavior
- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Computational Drug Discovery Methods
- Drug-Induced Hepatotoxicity and Protection
- Ion channel regulation and function
- Skin Protection and Aging
- Bee Products Chemical Analysis
- Receptor Mechanisms and Signaling
- Advancements in Transdermal Drug Delivery
- Memory and Neural Mechanisms
- Cancer therapeutics and mechanisms
National Research Council
2024
Italian Institute of Technology
2015-2024
Tecnologie Avanzate (Italy)
2024
University of Genoa
2009-2020
Istituto Nazionale di Fisica Nucleare, Sezione di Genova
2019-2020
Zero to Three
2012
Electrospun nanofibers of alginate containing lavender essential oil with antimicrobial and anti-inflammatory properties for the treatment UV-induced skin burns.
Cumulative evidence strongly supports that the amyloid and tau hypotheses are not mutually exclusive, but concomitantly contribute to neurodegeneration in Alzheimer's disease (AD). Thus, development of multitarget drugs which involved both pathways might represent a promising therapeutic strategy. Accordingly, reported here is discovery 6-amino-4-phenyl-3,4-dihydro-1,3,5-triazin-2(1H)-ones as first class molecules able simultaneously modulate BACE-1 GSK-3β. Notably, one triazinone showed...
Among the growing family of ribosomally synthesized, post-translationally modified peptides, particularly intriguing are class III lanthipeptides containing triamino acid labionin. In course a screening program aimed at finding bacterial cell wall inhibitors, we discovered new lanthipeptide produced by an Actinoplanes sp. The molecule, designated NAI-112, consists 22 amino acids and contains N-terminal labionin C-terminal methyl-labionin. Unique among lanthipeptides, it carries 6-deoxyhexose...
Abnormalities of synaptic transmission and plasticity in the hippocampus represent an integral part altered programming triggered by early life stress. Prenatally restraint stressed (PRS) rats develop long-lasting biochemical behavioral changes, which are expression anxious/depressive-like phenotype. We report here that PRS showed a selective impairment depolarization- or kainate-stimulated glutamate [(3)H]d-aspartate release ventral hippocampus, region encoding memories related to stress...
Autism spectrum disorders are neurodevelopmental conditions with diverse aetiologies, all characterized by common core symptoms such as impaired social skills and communication, well repetitive behaviour. Cell adhesion molecules, receptor tyrosine kinases associated downstream signalling have been strongly implicated in both neurodevelopment autism disorders. We found that downregulation of the cell molecule NEGR1 or kinase fibroblast growth factor 2 (FGFR2) similarly affects neuronal...
One of the main obstacles toward discovery effective anti-Alzheimer drugs is multifactorial nature its etiopathology. Therefore, use multitarget-directed ligands has emerged as particularly suitable. Such ligands, able to modulate different neurodegenerative pathways, for example, amyloid and tau cascades, well cognitive neurogenic functions, are fostered come. In this respect, we report herein on first class BACE-1/GSK-3β dual inhibitors based a 3,4-dihydro-1,3,5-triazin-2(1H)-one skeleton,...
Effective excretion of nanostructured noble metals is still one the most challenging bottlenecks for their employment in clinical practice. Besides persistence issue, translation inorganic nanomaterials also affected by a bewildering lack investigations regarding quantitative biokinetics. Here, we have quantitatively correlated chemical nature three interesting biomedical applications to biosafety and biokinetics in, respectively, zebrafish murine models. Gold, silver, platinum...
Aberrant expression ratio of Cl− transporters, NKCC1 and KCC2, is implicated in several brain conditions. inhibition by the FDA-approved diuretic drug, bumetanide, rescues core symptoms rodent models and/or clinical trials with patients. However, bumetanide has a strong effect due to kidney transporter NKCC2, creating critical drug compliance issues health concerns. Here, we report discovery new chemical class selective inhibitors lead candidate ARN23746. ARN23746 restores physiological...
In view of health and environmental concerns, together with the upcoming restrictive regulations on per- polyfluoroalkyl substances (PFAS), less impactful materials must be explored for hydrophobization surfaces. Polysaccharides, especially chitosan, are being their desirable properties film formation ease modification. We present a PFAS-free chitosan superhydrophobic coating textiles deposited through solvent-free method. By contact angle analysis drop impact, we observe that imparts...
In this study, hydrogels were produced using a Schiff base reaction between two hyaluronic acid derivatives: one containing aldehyde groups (HA-Ald) and the other holding diethylenetriamine with terminal amino (HA-DETA). The DETA portion promotes in situ growth, complexation, stabilization of silver nanoparticles (AgNPs), eliminating need for external reducing agents. HA-DETA HA-Ald leads to formation imine bonds, which results dynamically pH-responsive cross-linking. While capping ability...
The ability of nonsteroidal anti-inflammatory drugs (NSAIDs) to inhibit cyclooxygenase (Cox)-1 and Cox-2 underlies the therapeutic efficacy these drugs, as well their propensity damage gastrointestinal (GI) epithelium. This toxic action greatly limits use NSAIDs in inflammatory bowel disease (IBD) other chronic pathologies. Fatty acid amide hydrolase (FAAH) degrades endocannabinoid anandamide, which attenuates inflammation promotes GI healing. Here, we describe first class systemically...
Worldwide efforts are currently trying to produce effective risk assessment models for orally ingested nanoparticles. These tests should provide quantitative information on the bioaccessibility and bioavailability of products biotransformation, such as dissolved ionic species and/or aggregates. In vitro dissolution might be useful nanoparticle assessment, because their potential quantitatively monitor changes specific properties (e.g., dissolution, agglomeration, etc.), which critical...
Polyvinylpyrrolidone polymer was transformed into a controlled release films with natural antioxidant.
Rat hippocampal glutamatergic terminals possess NMDA autoreceptors whose activation by low micromolar elicits glutamate exocytosis in the presence of physiological Mg(2+) (1.2 mM), release being significantly reduced when compared to that Mg(2+)-free condition. Both and glycine were required evoke 1.2 mM Mg(2+), while dizocilpine, cis-4-[phosphomethyl]-piperidine-2-carboxylic acid 7-Cl-kynurenic prevented it, indicating occupation both agonist sites is needed for receptor activation....
Abstract The persistence of metals in the body after designed theranostic action has hampered clinical translation noble metal nanoparticles (NPs) to clinics. Therefore, appealing behaviors NPs for healthcare applications are still on bench‐side. Here, quantitative evaluation healthy murine models show that gold comprised passion fruit‐like nanoarchitectures (NAs) excreted daily over a 10 d period by both renal and biliary pathways biodegradation building blocks. Furthermore, histological...
Abstract Palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) are endogenous lipid mediators that suppress inflammation. Their actions terminated by the intracellular cysteine amidase, N ‐acylethanolamine acid amidase (NAAA). Even though NAAA may offer a new target for anti‐inflammatory therapy, lipid‐like structures reactive warheads of current inhibitors limit use these agents as oral drugs. A series novel benzothiazole–piperazine derivatives inhibit in potent selective manner...
Skin burns are debilitating injuries with significant morbidity and mortality associated infections sepsis, particularly in immunocompromised patients. In this context, nanotechnology can provide pioneering approaches for the topical treatment of burnt skin. Herein, recovery radiation-damaged skin by exploiting copper ultrasmall-in-nano architectures (CuNAs) dispersed a home-made cosmetic cream is described compared to other noble metals (such as gold). Owing their peculiar design...
Natural polymers from organic wastes have gained increasing attention in the biomedical field as resourceful second raw materials for design of devices which can perform a specific bioactive function and eventually degrade without liberating toxic residues surroundings. In this context, patches bandages, that need to support skin wound healing process short amount time be then discarded, certainly constitute good candidates our quest more environmentally friendly management. Here, we propose...