A5070031791- Parasitic infections in humans and animals
- Parasitic Infections and Diagnostics
- Congenital Anomalies and Fetal Surgery
- Cannabis and Cannabinoid Research
- Parasite Biology and Host Interactions
- Pharmacological Receptor Mechanisms and Effects
- Amoebic Infections and Treatments
- Retinal Development and Disorders
- Urological Disorders and Treatments
- Photoreceptor and optogenetics research
- CAR-T cell therapy research
- Systemic Sclerosis and Related Diseases
- Pharmacogenetics and Drug Metabolism
- Parasites and Host Interactions
- Multiple Sclerosis Research Studies
- Nerve injury and regeneration
- Sphingolipid Metabolism and Signaling
- Monoclonal and Polyclonal Antibodies Research
- Drug-Induced Hepatotoxicity and Protection
- Wheat and Barley Genetics and Pathology
- Echinoderm biology and ecology
- Autoimmune Bullous Skin Diseases
- Mycotoxins in Agriculture and Food
- Peripheral Neuropathies and Disorders
- Legal and Labor Studies
Centro Científico Tecnológico Mar del Plata
2021-2024
National University of Mar del Plata
2013-2024
Fundación Ciencias Exactas y Naturales
2007-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2014-2024
Italian Institute of Technology
2012-2018
Janssen (Switzerland)
2018
Johnson & Johnson (Switzerland)
2018
Centro Científico Tecnológico - San Juan
2007-2018
University of Trieste
2016
Nerviano Medical Sciences
2016
Pain and inflammation are major therapeutic areas for drug discovery. Current drugs these pathologies have limited efficacy, however, often cause a number of unwanted side effects. In the present study, we identify nonsteroidal anti-inflammatory carprofen as multitarget-directed ligand that simultaneously inhibits cyclooxygenase-1 (COX-1), COX-2, fatty acid amide hydrolase (FAAH). Additionally, synthesized tested several derivatives carprofen, sharing this multitarget activity. This may...
In addition to inhibiting the cyclooxygenase (COX)-mediated biosynthesis of prostanoids, various widely used nonsteroidal anti-inflammatory drugs (NSAIDs) enhance endocannabinoid signaling by blocking anandamide-degrading membrane enzyme fatty acid amide hydrolase (FAAH). The X-ray structure FAAH in complex with NSAID carprofen, along site-directed mutagenesis, activity assays, and NMR analysis, has revealed molecular details this interaction, providing information that may guide design dual...
The ability of nonsteroidal anti-inflammatory drugs (NSAIDs) to inhibit cyclooxygenase (Cox)-1 and Cox-2 underlies the therapeutic efficacy these drugs, as well their propensity damage gastrointestinal (GI) epithelium. This toxic action greatly limits use NSAIDs in inflammatory bowel disease (IBD) other chronic pathologies. Fatty acid amide hydrolase (FAAH) degrades endocannabinoid anandamide, which attenuates inflammation promotes GI healing. Here, we describe first class systemically...
Cystic echinococcosis is a global parasitic zoonosis caused by infection with the larval stage of Echinococcus granulosus sensu lato. affects more than 1 million people worldwide, causing important economic costs in terms management and livestock associated losses. Albendazole main drug used treating human cystic echinococcosis. In spite this, its low aqueous solubility, poor absorption, consequently erratic bioavailability are cause chemotherapeutic failures. Based on described problem, new...
The first set of rationally conceived dual dopamine D3 receptor (DRD3) and fatty acid amide hydrolase (FAAH) modulators is presented.
Alzheimer's disease (AD) is a slow-progressing of the brain characterized by symptoms such as impairment memory and other cognitive functions. AD associated with an inflammatory process that involves astrocytes microglial cells, among components. Astrocytes are most abundant type glial cells in central nervous system (CNS). They involved inducing neuroinflammation. The present study uses astrocyte-neuron cocultures to investigate how ARN14494, serine palmitoyltransferase (SPT) inhibitor,...
Human cystic echinococcosis remains a major public health problem on several countries and the treatment strategies are not solved. The aim of present work was to determine in vitro effect thymol Mentha piperita, M. pulegium, Rosmarinus officinalis essential oils proliferation E. granulosus larval cells. Isolated cells cellular aggregates were obtained from hydatid cyst's germinal layer exposed 1, 5, 10 μg/ml different for 7 days. Drug evaluated using test viability scanning electron...
The larval stage of the parasite
Abstract Inhibition of fatty acid amide hydrolase (FAAH) activity is under investigation as a valuable strategy for the treatment several disorders, including pain and drug addiction. A number potent FAAH inhibitors belonging to different chemical classes have been disclosed date; O ‐aryl carbamates are one most representative families. In search novel inhibitors, series ‐(1,2,3‐triazol‐4‐yl)methyl carbamate derivatives were designed synthesized exploiting copper‐ catalyzed [3+2]...
Alveolar echinococcosis is a neglected parasitic zoonosis caused by the metacestode Echinococcus multilocularis, which grows as malignant tumour-like infection in liver of humans. Albendazole (ABZ) antiparasitic drug choice for treatment disease. However, its effectiveness low, due to poor absorption from gastro-intestinal tract. It also parasitostatic and some cases produces side-effects. Therefore, an alternative this severe human disease necessary. In context, repositioning drugs combined...
Abstract Alveolar echinococcosis is a neglected parasitic zoonosis caused by Echinococcus multilocularis . The pharmacological treatment based on albendazole (ABZ). However, the low water solubility of drug produces limited dissolution rate, with consequent failure in disease. Solid dispersions are successful pharmacotechnical strategy to improve profile poorly water-soluble drugs. aim this work was determine vivo efficacy ABZ solid using poloxamer 407 as carrier (ABZ:P407 (SDs)) murine...
ABSTRACT Drug-resistance to chemotherapics in aggressive neuroblastoma (NB) is characterized by enhanced cell survival mediated TrkB and its ligand, brain-derived neurotrophic factor (BDNF); thus reduction BDNF levels represent a promising strategy overcome drug-resistance, but how regulate unknown. Here, cisplatin treatment SK-N-BE upregulated multiple transcripts, except exons 5 8 variants. Cisplatin increased mRNA protein, translation of firefly reporter gene flanked 5′UTR 1, 2c, 4 or 6...