A5002660712- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Histone Deacetylase Inhibitors Research
- Computational Drug Discovery Methods
- Tryptophan and brain disorders
- Parkinson's Disease Mechanisms and Treatments
- Immune cells in cancer
- Extracellular vesicles in disease
- Nuclear Receptors and Signaling
- Molecular Biology Techniques and Applications
- Metabolism and Genetic Disorders
- Neurogenetic and Muscular Disorders Research
- Mitochondrial Function and Pathology
- Adenosine and Purinergic Signaling
- Neonatal Respiratory Health Research
- Amino Acid Enzymes and Metabolism
- Epigenetics and DNA Methylation
- Nerve injury and regeneration
- ATP Synthase and ATPases Research
- Bioactive Compounds and Antitumor Agents
- Metabolomics and Mass Spectrometry Studies
University of Bologna
2015-2025
University of Verona
2020-2022
King's College London
2018-2021
University of Foggia
2007-2017
The critical role of neuroinflammation in favoring and accelerating the pathogenic process Alzheimer's disease (AD) increased need to target cerebral innate immune cells as a potential therapeutic strategy slow down progression. In this scenario, mesenchymal stem (MSCs) have risen considerable interest thanks their immunomodulatory properties, which been largely ascribed release extracellular vesicles (EVs), namely exosomes microvesicles. Indeed, beneficial effects MSC-EVs regulating...
Cumulative evidence strongly supports that the amyloid and tau hypotheses are not mutually exclusive, but concomitantly contribute to neurodegeneration in Alzheimer's disease (AD). Thus, development of multitarget drugs which involved both pathways might represent a promising therapeutic strategy. Accordingly, reported here is discovery 6-amino-4-phenyl-3,4-dihydro-1,3,5-triazin-2(1H)-ones as first class molecules able simultaneously modulate BACE-1 GSK-3β. Notably, one triazinone showed...
Endometrial lymphocytes play a critical role in endometrial receptivity. This study aimed at evaluating the variations induced by chronic endometritis (CE) on lymphocyte subsets. We compared results infertile women diagnosed with CE those unexplained without any sign of CE.Twenty-three referring for infertility had hysteroscopy and biopsy follicular phase; nine women, was (group CE+), while 14 it not CE-). All patients late secretory phase subsequent cycle underwent biopsy. By flow...
One of the main obstacles toward discovery effective anti-Alzheimer drugs is multifactorial nature its etiopathology. Therefore, use multitarget-directed ligands has emerged as particularly suitable. Such ligands, able to modulate different neurodegenerative pathways, for example, amyloid and tau cascades, well cognitive neurogenic functions, are fostered come. In this respect, we report herein on first class BACE-1/GSK-3β dual inhibitors based a 3,4-dihydro-1,3,5-triazin-2(1H)-one skeleton,...
Alzheimer's disease (AD) represents a global problem, with an estimation of the majority dementia patients in low- and middle-income countries by 2050. Thus, development sustainable drugs has attracted much attention recent years. In light this, taking inspiration from HDAC inhibitor vorinostat (1), we develop first inhibitors derived cashew nut shell liquid (CNSL), inexpensive agro-food waste material. CNSL derivatives 8 9 display inhibitory profile similar to 1, together more promising...
// Arcangelo Liso 1 , Stefano Castellani Francesca Massenzio Rosa Trotta Alessandra Pucciarini 2 Barbara Bigerna Pasquale De Luca 3 Pietro Zoppoli 4 Filippo Castiglione 5 Maria Concetta Palumbo Fabrizio Stracci 6 Matteo Landriscina 1,7 Giorgina Specchia 8 Leon A. Bach 9,10 Massimo Conese and Brunangelo Falini Department of Medical Surgical Sciences, University Foggia, Italy Institute Haematology, Perugia, Stazione Zoologica Dohrn, Naples, Dipartimento di Medicina Sperimentale e Clinica,...
The accurate characterisation of metabolic profiles is an important prerequisite to determine the rate and efficiency pathways taking place in cells. Changes balance metabolites involved vital processes such as glycolysis, tricarboxylic acid (TCA) cycle, oxidative phosphorylation (OXPHOS), well biochemical related amino acids, lipids, nucleotides, their precursors reflect physiological condition cells may contribute development various human diseases. feasible reliable measurement a wide...
Overcoming the lack of effective treatments and continuous clinical trial failures in neurodegenerative drug discovery might require a shift from prevailing paradigm targeting pathogenesis to one simultaneously neuroprotection neuroregeneration. In studies reported herein, we sought identify small molecules that exert neuroprotective neuroregenerative potential as tools against diseases. doing so, started neuroprotective/neuroregenerative mechanisms psychotropic drugs featuring tricyclic...
Aspartate-Glutamate Carrier 1 (AGC1) deficiency is a rare neurological disease caused by mutations in the solute carrier family 25, member 12 (SLC25A12) gene, encoding for mitochondrial aspartate-glutamate isoform (AGC1), component of malate-aspartate NADH shuttle (MAS), expressed excitable tissues only. AGC1 patients are children showing severe hypotonia, arrested psychomotor development, seizures and global hypomyelination. While effect neurons neuronal function has been deeply studied,...
Apolipoprotein E (ApoE) is mainly secreted by glial cells and involved in many brain functions, including neuronal plasticity, β-amyloid clearance, neuroprotection. Microglia--the main immune of the brain--are one source ApoE, but little known about physiologic regulation microglial ApoE secretion neurons whether this release changes under inflammatory or neurodegenerative conditions. Using rat primary neural cell cultures, we show that microglia through a Golgi-mediated pathway...
Polypharmacology is a new trend in amyotrophic lateral sclerosis (ALS) therapy and an effective way of addressing multifactorial etiology involving excitotoxicity, mitochondrial dysfunction, oxidative stress, microglial activation. Inspired by reported clinical trial, we converted riluzole (1)–rasagiline (2) combination into single-molecule multi-target-directed ligands. By ligand-based approach, the highly structurally integrated hybrids 3–8 were designed synthesized. Through target-...
Abstract Microglia represent the primary immune defense system within central nervous and play a role in inflammatory processes occurring numerous disorders, such as Parkinson’s disease (PD). PD onset progression are associated with factors considered possible causes of neuroinflammation, i.e. genetic mutations. In vitro models microglial cells were established to identify specific molecular targets through analysis gene expression data. Recently, Human Microglial Clone 3 cell line (HMC3)...
Lewy body dementia (LBD) represents the second most common neurodegenerative but is a quite underexplored therapeutic area. Nepflamapimod (1) brain-penetrant selective inhibitor of alpha isoform mitogen-activated serine/threonine protein kinase (MAPK) p38α, recently repurposed for LBD due to its remarkable antineuroinflammatory properties. Neuroprotective propargylamines are another class molecules with therapeutical potential against LBD. Herein, we sought combine core 1 and neuroprotective...
Glioblastoma (GB) is the most aggressive and prevalent glioma within Central Nervous System. GB exhibit a dismal 5-year survival rate (~6%) due to unfavorable prognosis lack of viable treatment options. Therefore, novel therapies with plant-derived compounds emerge as very promising. This study aims investigate antitumor activity 7α-acetoxy-6β-hydroxyroyleanone (Roy) in cell lines. Roy was isolated from Plectranthus hadiensis Schweinf. its mechanism assessed panel five lines mimic tumor...