A5103712517- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Retinoids in leukemia and cellular processes
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Bone and Joint Diseases
- Bone health and treatments
- Hematological disorders and diagnostics
- Chemokine receptors and signaling
- Neuroblastoma Research and Treatments
- Viral-associated cancers and disorders
- Cancer Immunotherapy and Biomarkers
- Renal Diseases and Glomerulopathies
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Cutaneous lymphoproliferative disorders research
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 and COVID-19 Research
University of Bari Aldo Moro
2014-2024
Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari
2019-2020
Hereditary hemorrhagic telangiectasia (HHT) is a genetic angiodysplasia affecting multiple organs. Two genes involved in the transduction of TGF-beta signalling are responsible for HHT. An additional role vascular endothelial growth factor (VEGF) has been proposed. Serum VEGF, which evaluated several diseases characterized by aberrant angiogenesis, never measured patients with HHT.To evaluate VEGF serum levels HHT as compared to normal subjects.32 (age 47.7 +/- 16.7 years) and control group...
// Giacomina Brunetti 1, * , Rita Rizzi 2, Angela Oranger 1 Isabella Gigante Giorgio Mori 3 Grazia Taurino Teresa Mongelli Graziana Colaianni Adriana Di Benedetto Roberto Tamma Giuseppe Ingravallo 4 Anna Napoli Maria Felicia Faienza 5 Mestice 2 Paola Curci Giorgina Specchia Silvia Colucci Grano Department of Basic and Medical Sciences, Neurosciences Sense Organs, section Human Anatomy Histology, University Bari, Italy Emergency Organ Transplantation, Section Hematology with Clinical...
BACKGROUND Extramedullary involvement is only occasionally observed in patients with acute promyelocytic leukemia (APL) but has been said to occur more frequently after treatment all-trans retinoic acid (ATRA) than cytotoxic drugs. In the literature, 37 well-documented cases have reported. METHODS The authors report 7 extramedullary APL documented by cytologic, phenotypic, and molecular analyses among 120 adult referred two different institutions during a period of 9 years. RESULTS this...
Recovery of cytomegalovirus (CMV)-specific CD8+ T cells after allogeneic stem cell transplantation (SCT) is critical for protection against CMV infection and disease. Moreover, Foxp3+CD4+CD25high regulatory (Tregs) are a major regulator adaptive immunity, preventing graft-versus-host disease (GVHD) so promoting timely complete immune recovery. The aim our study was to evaluate the recovery circulating tetramer-based CMV-specific regs in 46 patients peripheral blood SCT (PBSCT). and/or...
Bone disease associated with multiple myeloma (MM) is characterized by osteolytic lesions and pathological fractures, which remain a therapeutic priority despite new drugs improving MM patient survival. Antiresorptive molecules represent the main option for treatment of MM-associated bone (MMBD), whereas osteoanabolic are under investigation. Among these latter, we here focused on myokine irisin, able to enhance mass in healthy mice, prevent loss osteoporotic mouse models, accelerate...
Graft-versus-host disease (GVHD), mediated by mature T cells present in the donor graft, remains a major complication after allogeneic peripheral blood stem cell transplantation (PBSCT). Regulatory (Tregs) (CD4(+)CD25(high)Foxp3(+)) are believed to maintain tolerance and inhibit GVHD PBSCT (allo-PBSCT). In this study, we analyzed graft CD3(+)/Tregs ratio (gCD3/Tregs R) evaluated its impact on acute (aGVHD) immunologic recovery myeloablative allo-PBSCT. We 65 consecutive patients who...
Lymphoid enhancer-binding factor 1 (LEF1) is a downstream effector of the Wnt/ β-catenin signaling pathway. High LEF1 expression has been reported as prognostic marker in hematologic malignancies. We evaluated significance 78 adult acute promyelocytic leukemia (APL) patients. APL samples were dichotomized at median value and divided into: LEF1(low) LEF1(high). LEF1(high) patients had lower WBC counts baseline less likely to carry FLT3-ITD than Early death occurred only group. Moreover, was...
We have previously shown that through the production of high LIGHT levels, immune cells contribute to both osteoclastogenesis and bone destruction in Multiple Myeloma (MM)-related disease. With aim further exploring mechanisms underlying development MM-related disease, here we focused on a possible role MM patients with active disease despite treatment received. detected over-expression by circulating CD14+ monocytes from still showing treatment. In addition, found receptor activator nuclear...
The therapeutic efficacy of allogeneic peripheral blood stem cell transplantation (PBSCT) for hematological malignancies relies largely on the graft-versus-leukemia (GVL) effects exerted by donor CD3 cells, but there is a risk onset uncontrolled graft-versus-host disease (GVHD). Regulatory T cells (Tregs) (CD4+CD25(high) Foxp3+) are believed to maintain tolerance and inhibit acute GVHD (aGVHD) after PBSCT. Nevertheless, when looking at post-allotransplantation patient outcomes, although...
Nuclear invaginations, also referred to as fishmouth or cuplike nuclei, have long been identified in microgranular APL, myelomonocytic and monocytic AMLs. More recently, this typical morphological feature has associated with NPM1 FLT3 mutations, well the lack of CD34 HLA-DR expression. In study, we retrospectively analyzed morphologic, immunophenotypic, cytogenetic, molecular features 68 patients AML. A nuclear invagination was detected more than 10% blast cells 15 (22%) cases. Our data show...
This study aimed to identify which subset of CD34+ cells might be the most predictive early and long-term hematopoietic recovery following autologous peripheral blood stem cell (PBSC) transplantation (PBSCT) in adult acute myeloid leukemia (AML) patients. The relationships between number ‘mature’ subsets (CD34+/CD33+, CD34+/CD38+, CD34+/DR+ CD34+/CD90–) ‘immature’ (CD34+/CD33–, CD34+/CD38–, CD34+/DR– CD34+/CD90+) hemoglobin, neutrophil platelet counts were studied a homogeneous series (for...