A5089614080- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- CAR-T cell therapy research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Protein Tyrosine Phosphatases
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Multiple Myeloma Research and Treatments
- Galectins and Cancer Biology
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
- Eosinophilic Disorders and Syndromes
- Virus-based gene therapy research
- Nuclear Structure and Function
- Lung Cancer Diagnosis and Treatment
Ospedale Santa Maria
2015-2025
University of Perugia
2015-2024
Sapienza University of Rome
1997-2024
Azienda Ospedaliera di Perugia
2012-2024
Bernstein Center for Computational Neuroscience Tübingen
2023
Policlinico Umberto I
2022-2023
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2022
Carlo Forlanini Hospital
2003-2021
Assistance Publique – Hôpitaux de Paris
2021
Hôpital Européen Georges-Pompidou
2021
T cells that accompany allogeneic hematopoietic grafts for treating leukemia enhance engraftment and mediate the graft-versus-leukemia effect. Unfortunately, alloreactive also cause graft-versus-host disease (GVHD). cell depletion prevents GVHD but increases risk of graft rejection leukemic relapse. In human transplants, we show donor-versus-recipient natural killer (NK)–cell alloreactivity could eliminate relapse protect patients against GVHD. mice, pretransplant infusion NK obviated need...
Nucleophosmin (NPM), a nucleocytoplasmic shuttling protein with prominent nucleolar localization, regulates the ARF-p53 tumor-suppressor pathway. Translocations involving NPM gene cause cytoplasmic dislocation of protein.We used immunohistochemical methods to study subcellular localization in bone marrow-biopsy specimens from 591 patients primary acute myelogenous leukemia (AML). We then correlated presence clinical and biologic features disease.Cytoplasmic was detected 208 (35.2 percent)...
In this study we tried to achieve successful transplantation in patients with acute leukemia the use of hematopoietic stem cells from donors who shared only one HLA haplotype recipient (a “full-haplotype mismatch”). To prevent graft failure, large doses T-cell–depleted were transplanted after a conditioning regimen enhanced myeloablation and immunosuppression was administered recipient.
Hairy-cell leukemia (HCL) is a well-defined clinicopathological entity whose underlying genetic lesion still obscure.We searched for HCL-associated mutations by performing massively parallel sequencing of the whole exome leukemic and matched normal cells purified from peripheral blood an index patient with HCL. Findings were validated Sanger in 47 additional patients HCL.Whole-exome identified five missense somatic clonal that confirmed on sequencing, including heterozygous mutation BRAF...
Purpose Establishment of hematopoietic stem-cell (HSC) transplantation from mismatched relatives is feasible for patients with acute leukemia. As our original method graft processing was unsuitable large-scale clinical studies, we use automated devices CD34+ cell purification. Patients and Methods Sixty-seven myeloid leukemia (AML; 19 complete remission [CR] 1, 14 CR 2, nine > 25 in relapse) 37 lymphoid (ALL; eight two 13 were conditioned total-body irradiation, thiotepa, fludarabine,...
Acute myeloid leukemia (AML) carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc+ AML) accounts for about one-third of adult AML shows distinct features, including a unique gene expression profile. MicroRNAs (miRNAs) are small noncoding RNAs 19-25 nucleotides in length that have been linked to the development cancer. Here, we investigated role miRNAs biology NPMc+ AML. The miRNA was evaluated 85 de novo patients characterized subcellular localization/mutation status FLT3 using custom...
BRAF V600E is the genetic lesion underlying hairy-cell leukemia. We assessed safety and activity of oral inhibitor vemurafenib in patients with leukemia that had relapsed after treatment a purine analogue or who disease was refractory to analogues.