A5074288572- Free Radicals and Antioxidants
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Biochemical Acid Research Studies
- Vitamin C and Antioxidants Research
- Nitric Oxide and Endothelin Effects
- Sulfur Compounds in Biology
- Chemotherapy-induced cardiotoxicity and mitigation
- Electron Spin Resonance Studies
- Coenzyme Q10 studies and effects
- Cancer Treatment and Pharmacology
- Eicosanoids and Hypertension Pharmacology
- Computational Drug Discovery Methods
- Food composition and properties
- Carcinogens and Genotoxicity Assessment
- Alcoholism and Thiamine Deficiency
- Redox biology and oxidative stress
- Liver Disease Diagnosis and Treatment
- Exercise and Physiological Responses
- Receptor Mechanisms and Signaling
- Natural product bioactivities and synthesis
- Pharmacogenetics and Drug Metabolism
- Urinary Bladder and Prostate Research
Maastricht University
2016-2025
Hainan University
2023
Maastricht University Medical Centre
2008-2019
University Medical Center
2011-2016
New York University
2014
University of Cambridge
2014
University of Bonn
2010
University of Oslo
2002
Vrije Universiteit Amsterdam
1987-2001
Institute of Cytochemistry and Molecular Pharmacology
2001
Flavonoids are potent antioxidants. It is also known that flavonoids bind to proteins. The effect of the interaction between tea and proteins on antioxidant capacity was examined. Their separate combined capacities were measured with Trolox equivalent (TEAC) assay. observed several components green black alpha-, beta-, kappa-casein or albumin not additive; is, a part total masked by interaction. This masking depends both protein flavonoid used. Components in tea, which show highest...
Chronic inflammation has been recognized as a contributing factor in the pathogenesis of lung cancer. In this process, reactive oxygen species released by neutrophils may play an important role. The aim present study was to investigate capacity major neutrophilic oxidant hypochlorous acid (HOCl), which is formed myeloperoxidase (MPO), induce DNA damage and mutagenicity cells. HOCl mutagenic epithelial A549 cells vitro, showing at physiological concentrations significant induction mutations...
Endogenous antioxidants such as the lipid‐soluble vitamin E protect cell membranes from oxidative damage. Glutathione seems to be able regenerate α‐tocopherol via a so‐called free radical reductase. The transient protection by reduced glutathione (GSH) against lipid peroxidation in control liver microsomes is not observed deficient α‐tocopherol. Introduction of antioxidant flavonoids, 7‐monohydroxyethylrutoside, fisetin or naringenin, into restored GSH‐dependent protection, suggesting that...
Ferulic acid (FA) is the most abundant phenolic compound in wheat grain, mainly located bran. However, its bioaccessibility from bran matrix extremely low. Different bioprocessing techniques involving fermentation or enzymatic and treatments of were developed aiming at improving compounds bran-containing breads. The ferulic acid, p-coumaric sinapic was assessed with an vitro model upper gastrointestinal tract (TIM-1). Colonic metabolism nonbioaccessible fraction breads studied human colon...
The inhibition of the lipid peroxidation, induced by iron and ascorbate in rat liver microsomes, phenols flavones was studied. activity phenol enhanced electron donating substituents, denoted Hammett sigma (sigma). concentration substituted giving 50% (IC50) peroxidation gave a good correlation with substituent (ln(1/IC50) = -8.92sigma + 5.80 (R 0.94, p < 0.05)). In two pharmacophores for protection against were pinpointed: (i) catechol moiety as ring B (ii) an OH-group at 3 position groups...
Impaired nitric oxide (NO)-dependent vasorelaxation plays a key role in the development of diabetic vascular complications. We investigated effect hyperglycaemia on impaired vasoreactivity and putative therein AGE precursor methylglyoxal. The effects high glucose methylglyoxal NO-dependent isolated rat mesenteric arteries from wild-type transgenic glyoxalase (GLO)-I (also known as GLO1) rats, i.e. enzyme detoxifying methylglyoxal, were recorded wire myograph. formation major...