A5084729994- Free Radicals and Antioxidants
- Antioxidant Activity and Oxidative Stress
- Receptor Mechanisms and Signaling
- Phytochemicals and Antioxidant Activities
- Chemotherapy-induced cardiotoxicity and mitigation
- Vitamin C and Antioxidants Research
- Electron Spin Resonance Studies
- Nitric Oxide and Endothelin Effects
- Genomics, phytochemicals, and oxidative stress
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pharmacogenetics and Drug Metabolism
- Cancer Treatment and Pharmacology
- Glutathione Transferases and Polymorphisms
- Sulfur Compounds in Biology
- Mast cells and histamine
- Biochemical Acid Research Studies
- Consumer Attitudes and Food Labeling
- Adipose Tissue and Metabolism
- Biochemical effects in animals
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Computational Drug Discovery Methods
- Sarcoidosis and Beryllium Toxicity Research
- Exercise and Physiological Responses
- Neuroscience and Neuropharmacology Research
Maastricht University
2015-2024
Ild Care Foundation
2018-2024
St. Antonius Ziekenhuis
2020
GTx (United States)
2019
Center of Advanced European Studies and Research
2019
Maastricht University Medical Centre
2007-2015
European University Viadrina
2013
University Hospital Frankfurt
2011-2013
Goethe University Frankfurt
2011-2013
Universitätsmedizin Greifswald
2012
An imbalance between oxidative stress and antioxidative capacity is thought to play an important role in the development progression of chronic obstructive pulmonary disease (COPD). To assess lung status patients with COPD, we studied whether exhaled hydrogen peroxide (H2O2) increased breath condensate stable COPD (n = 12, mean FEV1 51% pred) exacerbated 19, actual 36% compared a healthy control group 10, 108% pred). Expired during 15 min tidal breathing was collected by cooling. The...
Flavonoids are potent antioxidants. It is also known that flavonoids bind to proteins. The effect of the interaction between tea and proteins on antioxidant capacity was examined. Their separate combined capacities were measured with Trolox equivalent (TEAC) assay. observed several components green black alpha-, beta-, kappa-casein or albumin not additive; is, a part total masked by interaction. This masking depends both protein flavonoid used. Components in tea, which show highest...
Flavonoids are a group of naturally occurring antioxidants, which over the past years have gained tremendous interest because their possible therapeutic applicability. The mechanism antioxidant activity has been extensively studied several decades. However, there is still much confusion about molecular radical scavenging and relationship between structure activity. Therefore, we calculated heat formation geometry both parent compound corresponding using ab initio program GAMESS. We compared...
Endogenous antioxidants such as the lipid‐soluble vitamin E protect cell membranes from oxidative damage. Glutathione seems to be able regenerate α‐tocopherol via a so‐called free radical reductase. The transient protection by reduced glutathione (GSH) against lipid peroxidation in control liver microsomes is not observed deficient α‐tocopherol. Introduction of antioxidant flavonoids, 7‐monohydroxyethylrutoside, fisetin or naringenin, into restored GSH‐dependent protection, suggesting that...
Ferulic acid (FA) is the most abundant phenolic compound in wheat grain, mainly located bran. However, its bioaccessibility from bran matrix extremely low. Different bioprocessing techniques involving fermentation or enzymatic and treatments of were developed aiming at improving compounds bran-containing breads. The ferulic acid, p-coumaric sinapic was assessed with an vitro model upper gastrointestinal tract (TIM-1). Colonic metabolism nonbioaccessible fraction breads studied human colon...
The inhibition of the lipid peroxidation, induced by iron and ascorbate in rat liver microsomes, phenols flavones was studied. activity phenol enhanced electron donating substituents, denoted Hammett sigma (sigma). concentration substituted giving 50% (IC50) peroxidation gave a good correlation with substituent (ln(1/IC50) = -8.92sigma + 5.80 (R 0.94, p < 0.05)). In two pharmacophores for protection against were pinpointed: (i) catechol moiety as ring B (ii) an OH-group at 3 position groups...