A5080579763- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac electrophysiology and arrhythmias
- Transplantation: Methods and Outcomes
- Animal Behavior and Welfare Studies
- Cardiac Structural Anomalies and Repair
- Organ Transplantation Techniques and Outcomes
- Anesthesia and Sedative Agents
- Heart Failure Treatment and Management
- Reproductive Physiology in Livestock
- Hemodynamic Monitoring and Therapy
- Mitochondrial Function and Pathology
- Anesthesia and Pain Management
- Cardiac Imaging and Diagnostics
- Circadian rhythm and melatonin
- Ion channel regulation and function
- Trauma and Emergency Care Studies
- Intensive Care Unit Cognitive Disorders
- Metabolism and Genetic Disorders
- Acute Kidney Injury Research
- Venous Thromboembolism Diagnosis and Management
- Cardiac Valve Diseases and Treatments
Kerckhoff Klinik
2021-2025
Düsseldorf University Hospital
2015-2024
Heinrich Heine University Düsseldorf
2015-2024
Amsterdam University Medical Centers
2024
Justus-Liebig-Universität Gießen
2023
Niigata City General Hospital
2018
Allgemeiner Deutscher Fahrrad-Club
2015
University of Amsterdam
2008-2012
Amsterdam UMC Location University of Amsterdam
2007-2010
Imperial College Healthcare NHS Trust
2010
The noble gas helium induces cardiac preconditioning. Whether activation of mitochondrial K(+) channels is involved in preconditioning (He-PC) unknown. authors investigated whether He-PC (1) mediated by Ca(2+) -sensitive potassium channels, (2) results uncoupling, and (3) age dependent.Anesthetized Wistar rats were randomly assigned to six groups (n = 10 each). Young (2-3 months) control (Con) aged (22-24 animals (Age Con) not treated further. Preconditioning (He-PC Age He-PC) inhaled 70%...
Remote ischemic preconditioning (RIPC) seems to be a promising cardioprotective strategy with contradictive clinical data suggesting the anesthetic regimen influencing favorable impact of RIPC. This study aimed investigate whether cardio protection by RIPC is abolished regimens. Male Wistar rats were randomized 6 groups. Anesthesia was either maintained pentobarbital (Pento) alone or combination sevoflurane (Sevo) and remifentanil propofol (Prop) in without reduced infarct size Pento-...
Extracorporeal life support (ECLS) is a promising therapeutic option for patients with refractory cardiogenic shock. However, as the mortality rate still remains high, there need early outcome parameters reflecting therapy success or futility. Therefore, we investigated whether liver enzyme levels could serve prognostic markers ECLS. The present study retrospective single-center cohort study. Adult >18 years of age who received ECLS between 2011 and 2018 were included. Bilirubin,...
Remote ischemic preconditioning (RIPC) protects the heart from ischemia and reperfusion (I/R) injury. The underlying molecular mechanisms are unclear. It has been demonstrated that Connexin 43 (Cx43) is critically involved in cardioprotective interventions including classical preconditioning. In present study we investigated influence of RIPC on expression patterns Cx43 after I/R rat vivo.Male Wistar rats were subjected to 35 min regional myocardial followed by 2 h with or without 4 cycles 5...
Mitochondrial large-conductance Ca2+-sensitive potassium (mBKCa) channels are involved in myocardial ischemic preconditioning. Their role sildenafil-induced cardioprotection is unknown. We investigated whether acute mediated by activation of mBKCa the rat heart vitro.Male Wistar rats (n = 8 per group) were randomized and anesthetized with pentobarbital (90 mg/kg). Hearts isolated, mounted on a Langendorff system perfused Krebs-Henseleit buffer at constant pressure 80 mmHg. underwent 30 min...
Preclinical and proof-of-concept studies suggest a cardioprotective effect of remote ischemic preconditioning (RIPC). However, two major clinical trials (ERICCA RIPHeart) failed to show cardioprotection by RIPC. Aging gender might be confounding factors RIPC affecting the inter-organ signalling. Theoretically, prevent protective potency interfering with cardiac signalling pathways, i.e. at heart, and/or release humoral factor(s) from organ, e.g. upper limb. This study investigated age sex on...
Timing and onset of myocardial ischemia are mostly unpredictable. Therefore, postconditioning could be an effective cardioprotective intervention. Because ischemic is invasive not practicable treatment, pharmacological would a more suitable alternative measure. For the α2-adrenoreceptor agonist, dexmedetomidine has been shown. However, data on concentration-dependent effect lacking. Furthermore, it unclear whether time point and/or duration administration in reperfusion period relevance. We...
Remote ischemic preconditioning (RIPC) is an easily applicable method for protecting the heart against a subsequent ischemia and reperfusion (I/R) injury. However, exact molecular mechanisms underlying RIPC are unknown. We examined involvement of microRNAs (miRNAs) in particular expression miRNA-1 (miR-1) myocardial ischemia. was conducted by four cycles 5-min bilateral hind-limb male Wistar rats. Cardiac induced ligation left anterior descending coronary artery 35 min followed 2 or 6 h...
Remote ischemic preconditioning (RIPC) is a practicable and noninvasive method to protect the heart against ischemia reperfusion injury. Unfortunately results from clinical studies are not convincing. Propofol suggested be an inhibiting factor of cardioprotection by RIPC, but underlying mechanism still unknown. We investigated whether after RIPC release humoral factors and/or direct cardioprotective effect at myocardium inhibited propofol.Randomized, prospective, blinded laboratory...
Background Morphine induces myocardial preconditioning (M-PC) via activation of mitochondrial large conductance Ca2+-sensitive potassium (mKCa) channels. An upstream regulator mKCa channels is protein kinase A (PKA). Furthermore, channel regulates bioenergetics and thereby prevents opening the permeability transition pore (mPTP). Here, we investigated in rat heart vivo whether 1) M-PC mediated by PKA, 2) pharmacological mPTP abolishes cardioprotective effect 3) critically dependent on STAT3...
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