Markus W. Hollmann
A5072986345- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Anesthesia and Sedative Agents
- Respiratory Support and Mechanisms
- Hemodynamic Monitoring and Therapy
- Intensive Care Unit Cognitive Disorders
- Nausea and vomiting management
- Airway Management and Intubation Techniques
- Diabetes Treatment and Management
- Enhanced Recovery After Surgery
- Sepsis Diagnosis and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Pain Management and Opioid Use
- Mitochondrial Function and Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Pain Mechanisms and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Pediatric Pain Management Techniques
- Spine and Intervertebral Disc Pathology
- COVID-19 Clinical Research Studies
- Neuropeptides and Animal Physiology
University of Amsterdam
2016-2025
Amsterdam University Medical Centers
2018-2025
Geneeskundige en Gezondheidsdienst
2025
Public Health Service of Amsterdam
2022-2025
Amsterdam UMC Location University of Amsterdam
2015-2024
European Society of Anaesthesiology
2021-2024
The Netherlands Cancer Institute
2012-2023
GGD Amsterdam
2021-2023
Mahidol Oxford Tropical Medicine Research Unit
2021-2022
Barro Colorado Island
2016-2022
Sodium–glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i) constitute a novel class of glucose-lowering (type 2) kidney-targeted agents. We recently reported that the SGLT2i empagliflozin (EMPA) reduced cardiac cytosolic Na+ ([Na+]c) and Ca2+ ([Ca2+]c) concentrations through inhibition Na+/H+ exchanger (NHE). Here, we examine (1) whether dapagliflozin (DAPA) canagliflozin (CANA) also inhibit NHE reduce [Na+]c; (2) structural model for interaction to NHE; (3) what extent affect haemodynamic...
<h3>Importance</h3> Intraoperative hypotension is associated with increased morbidity and mortality. A machine learning–derived early warning system to predict shortly before it occurs has been developed validated. <h3>Objective</h3> To test whether the clinical application of in combination a hemodynamic diagnostic guidance treatment protocol reduces intraoperative hypotension. <h3>Design, Setting, Participants</h3> Preliminary unblinded randomized trial performed tertiary center Amsterdam,...
Immunoglobulin G (IgG) antibodies are crucial for protection against invading pathogens. A highly conserved N-linked glycan within the IgG-Fc tail, which is essential IgG function, shows variable composition in humans. Afucosylated variants already used anticancer therapeutic their increased activity through Fc receptors (FcγRIIIa). Here, we report that afucosylated (approximately 6% of total humans) specifically formed enveloped viruses but generally not other antigens. This mediates...
If invasive measurement of arterial blood pressure is not warranted, finger cuff technology can provide continuous and noninvasive monitoring. Finger radial artery pressures differ; Nexfin® (BMEYE, Amsterdam, The Netherlands) measures uses physiologic reconstruction methodologies to obtain values comparable pressures.Intra-arterial (IAP) Nexfin (NAP) were measured in cardiothoracic surgery patients, because are available. NAP-IAP differences analyzed during 30 min. Tracking was quantified by...
BackgroundMortality rates are high among hospitalized patients with COVID-19, especially in those intubated on the ICU. Insight pathways associated unfavourable outcome may lead to new treatment strategies.MethodsWe performed a prospective cohort study of COVID-19 admitted general ward or ICU who underwent serial blood sampling. To provide insight involved disease progression, associations were estimated between risk and measurements 64 biomarkers potential important infection (inflammation,...
Summary Remimazolam, a short‐acting benzodiazepine, may be used for induction and maintenance of total intravenous anaesthesia, but its role in the management patients with multiple comorbidities remains unclear. In this phase 3 randomised controlled trial, we compared anaesthetic efficacy incidence postinduction hypotension during anaesthesia remimazolam vs. propofol. A 365 (ASA physical status or 4) scheduled elective surgery were assigned randomly to receive (n = 270) propofol 95)....
Background Mechanical ventilation with high tidal volumes aggravates lung injury in patients acute or respiratory distress syndrome. The authors sought to determine the effects of short-term mechanical on local inflammatory responses without preexisting injury. Methods Patients scheduled undergo an elective surgical procedure (lasting &gt; = 5 h) were randomly assigned either higher 12 ml/kg ideal body weight and no positive end-expiratory pressure (PEEP) lower 6 10 cm H2O PEEP. After...
The effective treatment of patients suffering from central neuropathic pain remains a clinical challenge, despite standard pharmacological approach in combination with anticonvulsants and antidepressants. A randomized, double-blinded, placebo-controlled trial evaluated the effects pregabalin on relief, tolerability, health status, quality life caused by brain or spinal cord injuries. At baseline 4 weeks after start subjects were measures efficacy: intensity measured visual analog scale,...